(data stored in SCRATCH3701 zone)

SWISSPROT: D5E8Z7_METMS

ID   D5E8Z7_METMS            Unreviewed;       890 AA.
AC   D5E8Z7;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 49.
DE   SubName: Full=Peptidase C1A papain {ECO:0000313|EMBL:ADE35648.1};
DE   Flags: Precursor;
GN   OrderedLocusNames=Mmah_0112 {ECO:0000313|EMBL:ADE35648.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35648.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35648.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001994; ADE35648.1; -; Genomic_DNA.
DR   RefSeq; WP_013036591.1; NC_014002.1.
DR   MEROPS; C01.167; -.
DR   EnsemblBacteria; ADE35648; ADE35648; Mmah_0112.
DR   GeneID; 8982243; -.
DR   KEGG; mmh:Mmah_0112; -.
DR   eggNOG; arCOG02542; Archaea.
DR   eggNOG; arCOG03607; Archaea.
DR   eggNOG; COG4870; LUCA.
DR   eggNOG; COG5479; LUCA.
DR   HOGENOM; HOG000161283; -.
DR   OrthoDB; 45296at2157; -.
DR   BioCyc; MMAH547558:G1GHT-111-MONOMER; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR040528; Lectin-like.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR026453; PGF_pre_PGF.
DR   Pfam; PF18560; Lectin_like; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   TIGRFAMs; TIGR04213; PGF_pre_PGF; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   4: Predicted;
DR   PRODOM; D5E8Z7.
DR   SWISS-2DPAGE; D5E8Z7.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        868..886
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          93..315
FT                   /note="Pept_C1"
FT                   /evidence="ECO:0000259|SMART:SM00645"
FT   DOMAIN          493..564
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|SMART:SM00060"
FT   DOMAIN          580..652
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|SMART:SM00060"
FT   REGION          830..868
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..865
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   890 AA;  97854 MW;  68CFCB0240286C44 CRC64;
     MLKRILLLTI ITLLLLNTAA LASENNPEIT SAPLNPDFID YQSSLQKSDE KTMLASSAQT
     PSYSLGLVPS PVDLSHLQPK KPGNNRLFTA QSLPGSYDLR EHNRLTPVKD QGDTGSCWTF
     ATYASLESCT YDEGPYNFSE NHMKNILSNE SPTGFDFEQG GSLDMATAYL ARWSGPVNET
     DDPYSDNSSY NDYTNPDKPV TRHVQEVIYL PPRNNVSAND HLKEAVREYG ALYTSFKVNR
     SAFADNATTY YYNGSEYEGG HAVALVGWND SFPKEEFIYE PPGDGAFIVK NSWGTELGDS
     GYLYISYYEE TFNAWAAAIF LSAANVDNHD NIYQYDPLGY TDSRGFSNST TVHGANVFQS
     SSEEYLEAVS FYTTDTNAVY NVSIYTNLSS STPVGQTLVA QTNGTFAHAG YHTVTLDTPV
     NLAEGQKFSV TNKISNPEHE YPLAAEYPES NYSSRASANP NESFMSFDGS NWTDVGKLNN
     TSICIKAFTS APPSNVSNLT AVVGSYWINW TWSNPDDKDF NHTEIYVNDT LISNTSDTYY
     NLTGLLDATN HSIGLRTVDT DGYVNSTWIN NTSQTLDIAP AAVTDLHVTS STSDSITWGW
     TNPANHDFDH VEIYLDNVFQ ANTSESVYRV SDLKSGHAYK IGLKTVDKAG NINNTTINDI
     ASTKSKSSGN AVKGITTSRE GRENIVSKSS QIQKVVADEN VYYDFEDGSI SFIEFKGTSN
     AGQIKILIEN LKDTSSLVDQ QPPGKVYSNF NVWVGDNRFD TNNLEDSMIG FKVSKTWLND
     INPDSVVLLH YTNAWQVLDT VQTEEDADYF YFEAQADGFS PFAISAVDST TGTDEISRPD
     DSEQSASGSA EPTAGNPSEN TTEPAETIPG PGVLAVLGII CILYVIRTRL
//

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