(data stored in SCRATCH3701 zone)

SWISSPROT: D5E9A3_METMS

ID   D5E9A3_METMS            Unreviewed;       460 AA.
AC   D5E9A3;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 66.
DE   RecName: Full=Aspartokinase {ECO:0000256|RuleBase:RU003448};
DE            EC=2.7.2.4 {ECO:0000256|RuleBase:RU003448};
GN   OrderedLocusNames=Mmah_0221 {ECO:0000313|EMBL:ADE35754.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35754.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35754.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC         Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC         Evidence={ECO:0000256|RuleBase:RU003448};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway; L-homoserine from L-aspartate: step 1/3.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 1/5. {ECO:0000256|RuleBase:RU004249}.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC       {ECO:0000256|RuleBase:RU003448}.
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DR   EMBL; CP001994; ADE35754.1; -; Genomic_DNA.
DR   EnsemblBacteria; ADE35754; ADE35754; Mmah_0221.
DR   KEGG; mmh:Mmah_0221; -.
DR   eggNOG; arCOG00861; Archaea.
DR   eggNOG; COG0527; LUCA.
DR   HOGENOM; HOG000293094; -.
DR   KO; K00928; -.
DR   OMA; INIMMIS; -.
DR   UniPathway; UPA00034; UER00015.
DR   UniPathway; UPA00050; UER00461.
DR   UniPathway; UPA00051; UER00462.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kinase.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF13840; ACT_7; 1.
DR   PIRSF; PIRSF000726; Asp_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 2.
PE   3: Inferred from homology;
DR   PRODOM; D5E9A3.
DR   SWISS-2DPAGE; D5E9A3.
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004249};
KW   Kinase {ECO:0000256|RuleBase:RU003448, ECO:0000313|EMBL:ADE35754.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   Transferase {ECO:0000256|RuleBase:RU003448, ECO:0000313|EMBL:ADE35754.1}.
FT   DOMAIN          321..391
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   DOMAIN          398..460
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   460 AA;  49066 MW;  F1ED22AF7D798183 CRC64;
     MKFGGTSIEK GDKIRHVAEL LKDYREQGHE IVAVTSALGG VTDGLMEIGI DASHKGKVSQ
     VKEFMADLAK KHYDAIEIAI DDAGIADETI RTIDALIDEL EKALIGICYL GELSPRSIDY
     ISSYGERLAA PVVSGAVQSQ GIDSSSFTGG EAGIVTNSEY GCARPFEKTY ESVGNILKKV
     VATQVPIVTG FIAENEEGII TTLGRSGSDF TASIIGAGID ADEIWLWKEV HGIMTSDPRI
     VPNARPIPQI SYIEAMELSY FGAKVLHPRT IEPAIKHGIP VRVKNTFDPE FEGTLIVSDQ
     RLRKDVVKAV TLIRSVAAIN ISGAGMVGAI GTAARVFSTL AKAGVNIIMI SQSSSEANMS
     FVVDEAHLED AVASLKSEMN RDVIGEVACD RDICVIAVVG AGMDGIPGVA GRVFSTLGKE
     KINVIMISQG SSQHNISFVV SSDEAEEAVR LLNHEFELGT
//

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