(data stored in SCRATCH3701 zone)

SWISSPROT: D5E9C9_METMS

ID   D5E9C9_METMS            Unreviewed;       325 AA.
AC   D5E9C9;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 59.
DE   RecName: Full=DNA repair and recombination protein RadA {ECO:0000256|HAMAP-Rule:MF_00348, ECO:0000256|PIRNR:PIRNR005856};
GN   Name=radA {ECO:0000256|HAMAP-Rule:MF_00348};
GN   OrderedLocusNames=Mmah_0248 {ECO:0000313|EMBL:ADE35780.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35780.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35780.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in DNA repair and in homologous recombination. Binds
CC       and assemble on single-stranded DNA to form a nucleoprotein filament.
CC       Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand
CC       exchange between homologous DNA molecules. {ECO:0000256|HAMAP-
CC       Rule:MF_00348, ECO:0000256|PIRNR:PIRNR005856}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RecA-like protein family.
CC       {ECO:0000256|HAMAP-Rule:MF_00348, ECO:0000256|PIRNR:PIRNR005856}.
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DR   EMBL; CP001994; ADE35780.1; -; Genomic_DNA.
DR   RefSeq; WP_013036723.1; NC_014002.1.
DR   EnsemblBacteria; ADE35780; ADE35780; Mmah_0248.
DR   GeneID; 8982380; -.
DR   KEGG; mmh:Mmah_0248; -.
DR   eggNOG; arCOG00415; Archaea.
DR   eggNOG; COG0468; LUCA.
DR   HOGENOM; HOG000227426; -.
DR   KO; K04483; -.
DR   OMA; YNTDHQT; -.
DR   OrthoDB; 30130at2157; -.
DR   BioCyc; MMAH547558:G1GHT-246-MONOMER; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008094; F:DNA-dependent ATPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   CDD; cd01123; Rad51_DMC1_radA; 1.
DR   HAMAP; MF_00348; RadA_arch; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR   InterPro; IPR011938; DNA_recomb/repair_RadA.
DR   InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR033925; Rad51_DMC1_RadA.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   Pfam; PF08423; Rad51; 1.
DR   PIRSF; PIRSF005856; Rad51; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF47794; SSF47794; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02236; recomb_radA; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5E9C9.
DR   SWISS-2DPAGE; D5E9C9.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00348};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00348, ECO:0000256|PIRNR:PIRNR005856,
KW   ECO:0000256|SAAS:SAAS00554563};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_00348,
KW   ECO:0000256|PIRNR:PIRNR005856, ECO:0000256|SAAS:SAAS00434332};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00348,
KW   ECO:0000256|PIRNR:PIRNR005856};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00348};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059}.
FT   DOMAIN          78..260
FT                   /note="RECA_2"
FT                   /evidence="ECO:0000259|PROSITE:PS50162"
FT   DOMAIN          265..325
FT                   /note="RECA_3"
FT                   /evidence="ECO:0000259|PROSITE:PS50163"
FT   NP_BIND         107..114
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00348"
SQ   SEQUENCE   325 AA;  35335 MW;  049E739EFF7636D9 CRC64;
     MSEILLEELD HVGPATAQKL NDAGYNSVEA VAVASPSELV ATAEIGESTA AKIISAARSA
     ADIGGFETGD FVMQRRMEVG KLRTGCEEFD ELMGGGIETQ SITEMYGEFG SGKTQIAHQL
     AVNTQLPKEM GGLDGSVIII DTENTFRPER IEHMVAGLSH KFEQDFDPAE FLKNIHVARA
     YNSNHQILLV DAATEMANKL KNTDKPVRLV IVDSLTAHFR AEYVGRGTLA DRQQKLNKHL
     HDLQRFGDLN NASVIVTNQV MSKPDAFFGD PTRPIGGHIL GHTATFRLYI RKSKGDKRIV
     KLVDSPCLPD GEAVACITTD GLCDA
//

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