(data stored in SCRATCH3701 zone)

SWISSPROT: D5E9J2_METMS

ID   D5E9J2_METMS            Unreviewed;       334 AA.
AC   D5E9J2;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 56.
DE   RecName: Full=Probable cobalamin biosynthesis protein CobD {ECO:0000256|HAMAP-Rule:MF_00024};
GN   Name=cobD {ECO:0000256|HAMAP-Rule:MF_00024};
GN   OrderedLocusNames=Mmah_0311 {ECO:0000313|EMBL:ADE35843.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35843.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35843.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC       aminopropanol on the F carboxylic group. {ECO:0000256|HAMAP-
CC       Rule:MF_00024}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00024}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00024};
CC       Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00024}.
CC   -!- SIMILARITY: Belongs to the CobD/CbiB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00024}.
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DR   EMBL; CP001994; ADE35843.1; -; Genomic_DNA.
DR   RefSeq; WP_013036786.1; NC_014002.1.
DR   EnsemblBacteria; ADE35843; ADE35843; Mmah_0311.
DR   GeneID; 8982444; -.
DR   KEGG; mmh:Mmah_0311; -.
DR   eggNOG; arCOG04274; Archaea.
DR   eggNOG; COG1270; LUCA.
DR   HOGENOM; HOG000290070; -.
DR   KO; K02227; -.
DR   OMA; NSGYTMA; -.
DR   OrthoDB; 101304at2157; -.
DR   BioCyc; MMAH547558:G1GHT-307-MONOMER; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015420; F:ATPase-coupled vitamin B12 transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00024; CobD_CbiB; 1.
DR   InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR   PANTHER; PTHR34308; PTHR34308; 1.
DR   Pfam; PF03186; CobD_Cbib; 1.
DR   TIGRFAMs; TIGR00380; cobD; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5E9J2.
DR   SWISS-2DPAGE; D5E9J2.
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00024};
KW   Cobalamin biosynthesis {ECO:0000256|HAMAP-Rule:MF_00024};
KW   Ligase {ECO:0000313|EMBL:ADE35843.1};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_00024};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00024}.
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
FT   TRANSMEM        57..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
FT   TRANSMEM        167..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
FT   TRANSMEM        217..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
FT   TRANSMEM        308..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
SQ   SEQUENCE   334 AA;  36316 MW;  CE48086249A77892 CRC64;
     MMDFIFAGYM HMIYVLLFAV LIDLAVGEPP ARLHPVVWIG TLIGIFKKYI PSSGRKAYGV
     FMGLSCILFA SLIAYIVLLV SSQSLVPELV GIVIEAYFLK STFAIRRLLF AGEEVASSLE
     VGALEEARKQ LSMYVSRDTS KLSGSHVSSA AIETVSENYV DSILSPLFYY SVAGPFGLIA
     AYAFKAVSTL DSMVGYRDEA HRDVGFFSAK LDDVLNWVPA RISLFFIWLA VFFLNIMPKT
     MSFDPSGACS CSTNDCKVPD SPNSGYPMAA VAGAIGVKLE KPGVYVLGQG LASPGAESIK
     KANRLVEGAA LISIACFSLV IYVFTNFIWK LYII
//

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