(data stored in SCRATCH3701 zone)

SWISSPROT: D5E9W7_METMS

ID   D5E9W7_METMS            Unreviewed;       493 AA.
AC   D5E9W7;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 44.
DE   RecName: Full=tRNA-splicing ligase RtcB {ECO:0000256|RuleBase:RU371113};
DE            EC=6.5.1.- {ECO:0000256|RuleBase:RU371113};
GN   Name=rtcB {ECO:0000256|RuleBase:RU371113};
GN   OrderedLocusNames=Mmah_0438 {ECO:0000313|EMBL:ADE35968.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35968.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35968.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR601233-3,
CC         ECO:0000256|RuleBase:RU371113};
CC       Note=Binds 2 manganese ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR601233-3, ECO:0000256|RuleBase:RU371113};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU371113}.
CC   -!- SIMILARITY: Belongs to the RtcB family.
CC       {ECO:0000256|RuleBase:RU371113}.
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DR   EMBL; CP001994; ADE35968.1; -; Genomic_DNA.
DR   RefSeq; WP_013036911.1; NC_014002.1.
DR   EnsemblBacteria; ADE35968; ADE35968; Mmah_0438.
DR   GeneID; 8982576; -.
DR   KEGG; mmh:Mmah_0438; -.
DR   eggNOG; arCOG04246; Archaea.
DR   eggNOG; COG1690; LUCA.
DR   HOGENOM; HOG000220065; -.
DR   KO; K14415; -.
DR   OMA; RGVECRK; -.
DR   OrthoDB; 22545at2157; -.
DR   BioCyc; MMAH547558:G1GHT-437-MONOMER; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008452; F:RNA ligase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.90.1860.10; -; 1.
DR   InterPro; IPR001233; RtcB.
DR   InterPro; IPR036025; RtcB-like_sf.
DR   PANTHER; PTHR11118; PTHR11118; 1.
DR   Pfam; PF01139; RtcB; 1.
DR   SUPFAM; SSF103365; SSF103365; 1.
DR   PROSITE; PS01288; UPF0027; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5E9W7.
DR   SWISS-2DPAGE; D5E9W7.
KW   Ligase {ECO:0000256|RuleBase:RU371113};
KW   Manganese {ECO:0000256|PIRSR:PIRSR601233-3, ECO:0000256|RuleBase:RU371113};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601233-3,
KW   ECO:0000256|RuleBase:RU371113};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059}.
FT   NP_BIND         341..342
FT                   /note="GMP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-2"
FT   NP_BIND         388..391
FT                   /note="GMP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-2"
FT   NP_BIND         416..419
FT                   /note="GMP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-2"
FT   ACT_SITE        416
FT                   /note="GMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-1"
FT   METAL           108
FT                   /note="Manganese 1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-3"
FT   METAL           111
FT                   /note="Manganese 1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-3"
FT   METAL           111
FT                   /note="Manganese 2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-3"
FT   METAL           216
FT                   /note="Manganese 1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-3"
FT   METAL           247
FT                   /note="Manganese 2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-3"
FT   METAL           341
FT                   /note="Manganese 2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-3"
FT   BINDING         397
FT                   /note="GMP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601233-2"
SQ   SEQUENCE   493 AA;  53131 MW;  239B5276197C7A1F CRC64;
     MKRGFDRMDT EGPEIEGLER IDNDIWQVPM GYKSGMRVPG RIYLSDKLFA NLEKEAVDQV
     ANVATLPGIQ KFSMAMPDAH VGYGFPIGGV AAFDAEEGVI SPGGVGFDIN CGVRLIRSNL
     DKSDVDGKVN DLLDSLFKAV PSGVGSKSRI RASESELEAI FTNGSRWAVE QGYGVEADLT
     HCEGEGCIEG GDPAQVSAKA RKRGRPQLGT LGSGNHFLEL QYVDEIYDPV AAEAFNLKQG
     QLTFMVHCGS RGAGHQVCTD HLRNLTRAVE KYKIDLPDKQ LACAPAQSEE AQAYFGAMAS
     AANYAWTNRQ IIMHHCREVF EQQMNMDADE LGLDLVYDVA HNVAKLEEHN VNGGKKQVYV
     HRKGATRAFP AGHHEVPKAY RDVGQPVLIP GSMGTPSYVL CGKQSAMDVS FGSACHGAGR
     VMSRSGAKHT FRGEQIQKDL SGQGISVRAA HPSVIAEEAP GVYKSSSEVV DVVDRLGIAG
     KVAKLMPVGV VKG
//

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