(data stored in SCRATCH3701 zone)

SWISSPROT: D5EA56_METMS

ID   D5EA56_METMS            Unreviewed;       604 AA.
AC   D5EA56;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 50.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000256|RuleBase:RU363031};
DE            EC=2.7.7.6 {ECO:0000256|RuleBase:RU363031};
GN   OrderedLocusNames=Mmah_0530 {ECO:0000313|EMBL:ADE36057.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE36057.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE36057.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000256|RuleBase:RU363031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA-
CC         COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:83400;
CC         EC=2.7.7.6; Evidence={ECO:0000256|RuleBase:RU363031};
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000256|RuleBase:RU363031}.
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DR   EMBL; CP001994; ADE36057.1; -; Genomic_DNA.
DR   RefSeq; WP_013037000.1; NC_014002.1.
DR   EnsemblBacteria; ADE36057; ADE36057; Mmah_0530.
DR   GeneID; 8982672; -.
DR   KEGG; mmh:Mmah_0530; -.
DR   eggNOG; arCOG01762; Archaea.
DR   eggNOG; COG0085; LUCA.
DR   HOGENOM; HOG000222962; -.
DR   KO; K03044; -.
DR   OMA; QKLYHMV; -.
DR   OrthoDB; 5510at2157; -.
DR   BioCyc; MMAH547558:G1GHT-533-MONOMER; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.40.270.10; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007646; RNA_pol_Rpb2_4.
DR   InterPro; IPR007647; RNA_pol_Rpb2_5.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   InterPro; IPR019969; RNAP_B.
DR   PANTHER; PTHR20856; PTHR20856; 1.
DR   Pfam; PF04566; RNA_pol_Rpb2_4; 1.
DR   Pfam; PF04567; RNA_pol_Rpb2_5; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   TIGRFAMs; TIGR03670; rpoB_arch; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5EA56.
DR   SWISS-2DPAGE; D5EA56.
KW   DNA-directed RNA polymerase {ECO:0000256|RuleBase:RU363031,
KW   ECO:0000313|EMBL:ADE36057.1};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363031,
KW   ECO:0000313|EMBL:ADE36057.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   Transcription {ECO:0000256|RuleBase:RU363031};
KW   Transferase {ECO:0000256|RuleBase:RU363031, ECO:0000313|EMBL:ADE36057.1}.
FT   DOMAIN          6..67
FT                   /note="RNA_pol_Rpb2_4"
FT                   /evidence="ECO:0000259|Pfam:PF04566"
FT   DOMAIN          89..128
FT                   /note="RNA_pol_Rpb2_5"
FT                   /evidence="ECO:0000259|Pfam:PF04567"
FT   DOMAIN          135..507
FT                   /note="RNA_pol_Rpb2_6"
FT                   /evidence="ECO:0000259|Pfam:PF00562"
FT   DOMAIN          509..599
FT                   /note="RNA_pol_Rpb2_7"
FT                   /evidence="ECO:0000259|Pfam:PF04560"
SQ   SEQUENCE   604 AA;  67241 MW;  EA0FAEF44484E05B CRC64;
     MTDAKVFLNG ELIGTHPDPV NLVEDIRKQR RAGMLSRQVN VALYEDIHEV IINSDIGRAR
     RALVVVENGL PLVTEDHIDK LKSGDLTSED LIRQGRIEYL DAEEEENSYV ALYEEDITPK
     HTHLEIDPSL ILGICAGMVP YPEHNASPRI TMGAAMLKQC IGVSTSNLKL RPDTRAHVLH
     YPQKALTRTQ TCDSIHFDER PAGQNFVVAV MSYEGYNIED ALVFNKGSIE RGLGRSHFVR
     TFEGEERRYP GGQEDKFEIP DSEYRGARSA EAYANLDVDG LVNPETTVGP NSVLIGKTSP
     PRFLEEQTDF GITVEQRRES AITMRSNEKG VVDTVLLTES INGTRLTKVK VRDQRIPEIG
     DKFASRHGQK GVIGLIVPYQ DMPFTESGMV PDLVLNPHAI PSRMTVGHVL EMIGGKVGSI
     EGRRIKATAF SGENEDDLRA GLQNHGFSHT GKEVFYDGVT GKKVQADIFV GVILYQKLHH
     MVASKMHARS RGPVQVLTRQ PTEGRAREGG LRFGEMERDV MIGHGAAMTL KERLLDESDK
     VEELVCGNCG MIATFDRRRN VRYCSNCGSE TDIHRVEMSY AFKLLLDEIK SLGVAPRLRL
     DDAV
//

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