(data stored in ACNUC1104 zone)

SWISSPROT: D5UPT9_TSUPD

ID   D5UPT9_TSUPD            Unreviewed;       184 AA.
AC   D5UPT9;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   08-MAY-2019, entry version 43.
DE   RecName: Full=dTDP-4-dehydrorhamnose 3,5-epimerase {ECO:0000256|RuleBase:RU364069};
DE            EC=5.1.3.13 {ECO:0000256|RuleBase:RU364069};
DE   AltName: Full=Thymidine diphospho-4-keto-rhamnose 3,5-epimerase {ECO:0000256|RuleBase:RU364069};
GN   OrderedLocusNames=Tpau_0053 {ECO:0000313|EMBL:ADG76707.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG76707.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG76707.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- FUNCTION: Catalyzes the epimerization of the C3' and C5'positions
CC       of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-
CC       hexulose. {ECO:0000256|RuleBase:RU364069}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-
CC         beta-L-rhamnose; Xref=Rhea:RHEA:16969, ChEBI:CHEBI:57649,
CC         ChEBI:CHEBI:62830; EC=5.1.3.13;
CC         Evidence={ECO:0000256|RuleBase:RU364069};
CC   -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC       {ECO:0000256|RuleBase:RU364069}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU364069}.
CC   -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase
CC       family. {ECO:0000256|RuleBase:RU364069}.
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DR   EMBL; CP001966; ADG76707.1; -; Genomic_DNA.
DR   RefSeq; WP_013124762.1; NC_014158.1.
DR   STRING; 521096.Tpau_0053; -.
DR   EnsemblBacteria; ADG76707; ADG76707; Tpau_0053.
DR   KEGG; tpr:Tpau_0053; -.
DR   eggNOG; ENOG4108URP; Bacteria.
DR   eggNOG; COG1898; LUCA.
DR   HOGENOM; HOG000227724; -.
DR   KO; K01790; -.
DR   OMA; DVCYRID; -.
DR   OrthoDB; 1618609at2; -.
DR   BioCyc; TPAU521096:G1GKO-54-MONOMER; -.
DR   UniPathway; UPA00124; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0008830; F:dTDP-4-dehydrorhamnose 3,5-epimerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR000888; dTDP_sugar_isom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR21047; PTHR21047; 1.
DR   Pfam; PF00908; dTDP_sugar_isom; 1.
DR   ProDom; PD001462; dTDP_sugar_isom; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR01221; rmlC; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5UPT9.
DR   SWISS-2DPAGE; D5UPT9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Isomerase {ECO:0000256|RuleBase:RU364069,
KW   ECO:0000313|EMBL:ADG76707.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213}.
SQ   SEQUENCE   184 AA;  20220 MW;  C1A54DCF972A1C29 CRC64;
     MRIEATDLSD VVLLVPEPHR DQRGLFTRTF DAEEFDAHLG VPGASASFVQ DSQSRSHGGV
     VRGLHGRSGR GEAKLVRCAH GAVLDVLVDI RPDSPTFGRH ASFRLDDENF HHLYVPPGFL
     HGFQALTPVA DVCYRIDRPH DPNEDLGVVY NDPDLAISWP LPVTVVSSRE AAAGSWSELQ
     HGLR
//

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