(data stored in ACNUC1104 zone)

SWISSPROT: D5UPW7_TSUPD

ID   D5UPW7_TSUPD            Unreviewed;       751 AA.
AC   D5UPW7;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   08-MAY-2019, entry version 66.
DE   SubName: Full=Heavy metal translocating P-type ATPase {ECO:0000313|EMBL:ADG76735.1};
GN   OrderedLocusNames=Tpau_0081 {ECO:0000313|EMBL:ADG76735.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG76735.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG76735.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362081}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type)
CC       (TC 3.A.3) family. Type IB subfamily.
CC       {ECO:0000256|RuleBase:RU362081}.
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DR   EMBL; CP001966; ADG76735.1; -; Genomic_DNA.
DR   RefSeq; WP_013124790.1; NC_014158.1.
DR   STRING; 521096.Tpau_0081; -.
DR   EnsemblBacteria; ADG76735; ADG76735; Tpau_0081.
DR   KEGG; tpr:Tpau_0081; -.
DR   eggNOG; ENOG4105C59; Bacteria.
DR   eggNOG; COG2217; LUCA.
DR   HOGENOM; HOG000250397; -.
DR   KO; K12949; -.
DR   OMA; NDGCTII; -.
DR   OrthoDB; 237367at2; -.
DR   BioCyc; TPAU521096:G1GKO-82-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030001; P:metal ion transport; IEA:InterPro.
DR   CDD; cd00371; HMA; 1.
DR   Gene3D; 3.40.1110.10; -; 1.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR000579; Cation-trans_P-type_ATPase_A/B.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR017969; Heavy-metal-associated_CS.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   Pfam; PF00403; HMA; 1.
DR   PRINTS; PR00940; CATPATPASEA.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   SUPFAM; SSF81653; SSF81653; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   TIGRFAMs; TIGR01525; ATPase-IB_hvy; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS01047; HMA_1; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5UPW7.
DR   SWISS-2DPAGE; D5UPW7.
KW   ATP-binding {ECO:0000256|RuleBase:RU362081};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Membrane {ECO:0000256|RuleBase:RU362081};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00280,
KW   ECO:0000256|RuleBase:RU362081};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Transmembrane {ECO:0000256|RuleBase:RU362081};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    112    133       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    139    157       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    177    196       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    216    234       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    369    391       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    403    425       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    703    719       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    725    743       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   DOMAIN       25     89       HMA. {ECO:0000259|PROSITE:PS50846}.
FT   METAL        35     35       {ECO:0000256|PROSITE-ProRule:PRU00280}.
FT   METAL        38     38       {ECO:0000256|PROSITE-ProRule:PRU00280}.
SQ   SEQUENCE   751 AA;  77805 MW;  BD4783FC94FE3C2C CRC64;
     MTDLQSAAPP ASADESADAT AEAQRTFLDV GGMTCAACVG RVERKLNKLD GVRAVVNLAT
     RTATVEHAPT VTVEQLTGTV EAAGYTAAPK SPNPRRAMLA EERERRDVLR RLVVSLVLFV
     PAADLSIVLA IIPSTRFPGW QWVLLALSLP VVTWGAWPLH KKAWQGARHG AATMDTLVSV
     GIISATAWSV VTVLTPGRQR PDPHGLWNAI VQSDPIYLEV AMGVTVFVLA GRYFEASARA
     KAASALRDLS TRGARDVSVL VRDGSELRIP IGELREDQVF VVRPGETIAT DGVVESGSAF
     VDNSAMTGES RPVPAGPGDR VVGGTVCQDG RLTVRAIAVG EDTTFAAMLR LVEDAQATKA
     RMQRLADRVS AVFVPCVFAI AALTFAGWML FGGSIDDAVK AAIAVLVIAC PCALGLATPV
     AFMVASGRGA QLGVYVRGHQ ALEATESIDT VVFDKTGTVT TGLLEVAAIA VADGFTEAQV
     LRLAGAVETA SEHAVARAVV ARAGADLPAV EDFRAVPGLG ATGTVDGRTV RVGNPRFVSP
     GVLAPAVDAA AEAGRTVAVV EVDGAVAAVM EIADTIKPDA RAAITRLHEA GITTVLLTGD
     NAAAAAKVAA AVGIDDIRSD VLPEGKVAEI RALQAEGRRV AMVGDGVNDG PALAAADLGL
     AMGTGTDVAQ GAADVVLMRE ELSAVPDALG LARATLKTIK TNLVWAFGYN VAAIPIAAAG
     LLNPLISAAA MSFSSFFVVW NSLRLRRFGS R
//

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