(data stored in ACNUC1104 zone)

SWISSPROT: D5UQL3_TSUPD

ID   D5UQL3_TSUPD            Unreviewed;       473 AA.
AC   D5UQL3;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   13-FEB-2019, entry version 46.
DE   RecName: Full=NAD(P) transhydrogenase subunit beta {ECO:0000256|PIRNR:PIRNR000204};
DE            EC=7.1.1.1 {ECO:0000256|PIRNR:PIRNR000204};
DE   AltName: Full=Nicotinamide nucleotide transhydrogenase subunit beta {ECO:0000256|PIRNR:PIRNR000204};
GN   OrderedLocusNames=Tpau_0192 {ECO:0000313|EMBL:ADG76846.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG76846.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG76846.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled
CC       to respiration and ATP hydrolysis and functions as a proton pump
CC       across the membrane. {ECO:0000256|PIRNR:PIRNR000204}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+);
CC         Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349;
CC         EC=7.1.1.1; Evidence={ECO:0000256|PIRNR:PIRNR000204};
CC   -!- SIMILARITY: Belongs to the PNT beta subunit family.
CC       {ECO:0000256|PIRNR:PIRNR000204}.
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DR   EMBL; CP001966; ADG76846.1; -; Genomic_DNA.
DR   RefSeq; WP_013124901.1; NC_014158.1.
DR   STRING; 521096.Tpau_0192; -.
DR   EnsemblBacteria; ADG76846; ADG76846; Tpau_0192.
DR   KEGG; tpr:Tpau_0192; -.
DR   eggNOG; ENOG4105C15; Bacteria.
DR   eggNOG; COG1282; LUCA.
DR   HOGENOM; HOG000243958; -.
DR   KO; K00325; -.
DR   OMA; AMTSMPE; -.
DR   OrthoDB; 788546at2; -.
DR   BioCyc; TPAU521096:G1GKO-191-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR012136; NADH_DH_b.
DR   InterPro; IPR034300; PNTB-like.
DR   Pfam; PF02233; PNTB; 1.
DR   PIRSF; PIRSF000204; PNTB; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5UQL3.
DR   SWISS-2DPAGE; D5UQL3.
KW   Cell inner membrane {ECO:0000256|PIRNR:PIRNR000204};
KW   Cell membrane {ECO:0000256|PIRNR:PIRNR000204};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Membrane {ECO:0000256|PIRNR:PIRNR000204, ECO:0000256|SAM:Phobius};
KW   NAD {ECO:0000256|PIRNR:PIRNR000204};
KW   NADP {ECO:0000256|PIRNR:PIRNR000204};
KW   Oxidoreductase {ECO:0000313|EMBL:ADG76846.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Translocase {ECO:0000256|PIRNR:PIRNR000204};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM      6     23       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     35     54       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     60     81       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     93    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    140    161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    177    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    201    220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    252    271       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        8    470       PNTB. {ECO:0000259|Pfam:PF02233}.
SQ   SEQUENCE   473 AA;  49895 MW;  50B816EEA7A8170A CRC64;
     MSVESIATAA YLVAALLFIL SLAGLSKHES ARTGWLYGVI GMVIAIAATV ALALNKSEVA
     GTATVILVVT ALIGAAIGLY RARVVQMTGM PELIALLHSF VGLAAVLVGW ASYLEVERGW
     IPGEAAHYTG GLLKIHHAEV FIGVFIGAVT FTGSIVAYLK LSAKMKSAPL VLPGKNYINI
     GALVLFAVFT VWFVIDQQLW LLIAVTVIAL LLGWHLVASI GGGDMPVVVS MLNSYSGWAA
     AAAGFLLSND LLIVTGALVG SSGAYLSYIM CKAMNRSFIS VIAGGFGIEA APSEDQDYGE
     HTETNADSVA ELLKNAKTVV ITPGYGMAVA QAQYGVAELT RELRKRGVTV RFGIHPVAGR
     LPGHMNVLLA EAKVPYDIVL EMDEINDDFA DTDVVLVIGA NDTVNPAAAE DPNSPIAGMP
     VLTVWEAENV IVFKRSMASG YAGVQNPLFF RTNSAMLFGD AKDRVQDILA AIN
//

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