(data stored in ACNUC1104 zone)

SWISSPROT: D5URH6_TSUPD

ID   D5URH6_TSUPD            Unreviewed;       392 AA.
AC   D5URH6;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   08-MAY-2019, entry version 41.
DE   RecName: Full=Beta-lactamase {ECO:0000256|RuleBase:RU361140};
DE            EC=3.5.2.6 {ECO:0000256|RuleBase:RU361140};
GN   OrderedLocusNames=Tpau_0388 {ECO:0000313|EMBL:ADG77029.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG77029.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG77029.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC         Evidence={ECO:0000256|RuleBase:RU361140};
CC   -!- SIMILARITY: Belongs to the class-C beta-lactamase family.
CC       {ECO:0000256|RuleBase:RU361140}.
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DR   EMBL; CP001966; ADG77029.1; -; Genomic_DNA.
DR   MEROPS; S12.006; -.
DR   EnsemblBacteria; ADG77029; ADG77029; Tpau_0388.
DR   KEGG; tpr:Tpau_0388; -.
DR   eggNOG; ENOG41066YJ; Bacteria.
DR   eggNOG; COG1680; LUCA.
DR   HOGENOM; HOG000267102; -.
DR   KO; K01467; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017001; P:antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR   InterPro; IPR001466; Beta-lactam-related.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001586; Beta-lactam_class-C_AS.
DR   Pfam; PF00144; Beta-lactamase; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
DR   PROSITE; PS00336; BETA_LACTAMASE_C; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5URH6.
DR   SWISS-2DPAGE; D5URH6.
KW   Antibiotic resistance {ECO:0000256|RuleBase:RU361140};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Hydrolase {ECO:0000256|RuleBase:RU361140,
KW   ECO:0000313|EMBL:ADG77029.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    392       Beta-lactamase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5003077664.
FT   DOMAIN       42    379       Beta-lactamase. {ECO:0000259|Pfam:
FT                                PF00144}.
SQ   SEQUENCE   392 AA;  41420 MW;  F7DAA26204619CF4 CRC64;
     MRSLIAAVLT AAVMTGCSAQ PAEHPNQSPS AAPDQVSTTA RSVITELRRA HAIPGIAVAV
     VLGARTTVVT DGTLGAEDSR AVGPDTLFEI GSVSKIYTAL LGATAEADGR ISLQDSPARF
     LPWLRGTPLA GVTLDQLGTY TAGEFPLQFP PSVTDETSMR DYFTTWRPTA PAGTTRRYAN
     PSIGLFGLSA AAAYGMDYPV ALRERVLTPL DLRDTYISIP DSAADRYAWG RTSDSPRVRL
     SPRPLDAEAY GVKTTPSDLA AFTAAFMNPT TPPAIRSAMQ PRYEVSPMRQ SLGWEGIASP
     ATRKRVQDAN AAGITGASRP VTPTGPEPSC LLNKTGSTKG FGTYVLLHPG SRTGVALLAN
     RNIPIPDRID AAFDILSAAV PNLSCSPQRT PR
//

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