(data stored in ACNUC1104 zone)

SWISSPROT: D5US60_TSUPD

ID   D5US60_TSUPD            Unreviewed;       613 AA.
AC   D5US60;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   08-MAY-2019, entry version 52.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000256|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000256|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000256|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000256|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000256|HAMAP-Rule:MF_00332};
GN   OrderedLocusNames=Tpau_0486 {ECO:0000313|EMBL:ADG77127.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG77127.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG77127.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000256|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock.
CC       {ECO:0000256|HAMAP-Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000256|HAMAP-Rule:MF_00332, ECO:0000256|RuleBase:RU003322}.
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DR   EMBL; CP001966; ADG77127.1; -; Genomic_DNA.
DR   RefSeq; WP_013125169.1; NC_014158.1.
DR   STRING; 521096.Tpau_0486; -.
DR   PRIDE; D5US60; -.
DR   EnsemblBacteria; ADG77127; ADG77127; Tpau_0486.
DR   KEGG; tpr:Tpau_0486; -.
DR   eggNOG; ENOG4105CFG; Bacteria.
DR   eggNOG; COG0443; LUCA.
DR   HOGENOM; HOG000228137; -.
DR   KO; K04043; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   BioCyc; TPAU521096:G1GKO-469-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 2.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; D5US60.
DR   SWISS-2DPAGE; D5US60.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00332,
KW   ECO:0000256|RuleBase:RU003322};
KW   Chaperone {ECO:0000256|HAMAP-Rule:MF_00332};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00332,
KW   ECO:0000256|RuleBase:RU003322};
KW   Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_00332};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Stress response {ECO:0000256|HAMAP-Rule:MF_00332}.
FT   COILED      224    251       {ECO:0000256|SAM:Coils}.
FT   COILED      490    519       {ECO:0000256|SAM:Coils}.
FT   COILED      536    556       {ECO:0000256|SAM:Coils}.
FT   MOD_RES     175    175       Phosphothreonine; by autocatalysis.
FT                                {ECO:0000256|HAMAP-Rule:MF_00332}.
SQ   SEQUENCE   613 AA;  65530 MW;  C18D51FF3DC01D46 CRC64;
     MGRAVGIDLG TTNSCVAVLE GGDPVVIANA EGSRTTPSVV AFARNGEVLV GQPAKNQAVT
     NVDRTIRSVK RHIGTDWSQK IDDKDYTSQE ISARTLMKLK RDAEAYLGED VTDAVVTVPA
     YFNDAQRQAT KEAGQIAGLN VLRIVNEPTA AALAYGLDKG EKEQTILVFD LGGGTFDVSL
     LEIGDGVVEV RATSGDNNLG GDDWDQRIVD WLVEKFKAQH GIDLTKDKMA MQRLREAAEK
     AKIELSSGQS TSINLPYITV DADKNPLFLD ENLSRSEFQK ITSDLLERTR SPFQAVIKDA
     GISVGDIDHV VLVGGSTRMP AVTDLVKELT GGQEPNKGVN PDEVVAVGAA LQAGVLRGEV
     KDVLLLDVTP LSLGIETKGG VMTKLIERNT TIPTKRSETF TTADDNQPSV QIQVFQGERE
     IAAHNKLLGS FELTGIAPAP RGVPQIEVTF DIDANGIVHV TAKDKGTGKE NTIKISDGSG
     LSQEEIDRMI KDAEAHASED KARREEAETR NQAESLVNQT EKFLSENADK VPAENKEKVE
     AAIKEANEAL QGTDIAAVKA AVEKLSTESQ ALGQALYAQA GAEAQAEGAE QAAQADDGVV
     DAEVVDEDPK DAK
//

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