(data stored in ACNUC1104 zone)

SWISSPROT: D5USA2_TSUPD

ID   D5USA2_TSUPD            Unreviewed;       253 AA.
AC   D5USA2;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=rRNA (Adenine-N(6)-)-methyltransferase {ECO:0000313|EMBL:ADG77169.1};
GN   OrderedLocusNames=Tpau_0528 {ECO:0000313|EMBL:ADG77169.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG77169.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG77169.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. rRNA adenine N(6)-methyltransferase
CC       family. {ECO:0000256|PROSITE-ProRule:PRU01026}.
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DR   EMBL; CP001966; ADG77169.1; -; Genomic_DNA.
DR   RefSeq; WP_013125211.1; NC_014158.1.
DR   STRING; 521096.Tpau_0528; -.
DR   EnsemblBacteria; ADG77169; ADG77169; Tpau_0528.
DR   KEGG; tpr:Tpau_0528; -.
DR   eggNOG; ENOG4108SM1; Bacteria.
DR   eggNOG; COG0030; LUCA.
DR   HOGENOM; HOG000075970; -.
DR   KO; K00561; -.
DR   OMA; TMMTAQW; -.
DR   OrthoDB; 2030110at2; -.
DR   BioCyc; TPAU521096:G1GKO-511-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000179; F:rRNA (adenine-N6,N6-)-dimethyltransferase activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR001737; KsgA/Erm.
DR   InterPro; IPR020596; rRNA_Ade_Mease_Trfase_CS.
DR   InterPro; IPR020598; rRNA_Ade_methylase_Trfase_N.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   PANTHER; PTHR11727; PTHR11727; 1.
DR   Pfam; PF00398; RrnaAD; 1.
DR   SMART; SM00650; rADc; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS01131; RRNA_A_DIMETH; 1.
DR   PROSITE; PS51689; SAM_RNA_A_N6_MT; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5USA2.
DR   SWISS-2DPAGE; D5USA2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01026,
KW   ECO:0000313|EMBL:ADG77169.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU01026};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01026};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01026,
KW   ECO:0000313|EMBL:ADG77169.1}.
FT   DOMAIN       21    180       rADc. {ECO:0000259|SMART:SM00650}.
FT   BINDING      14     14       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01026}.
FT   BINDING      16     16       S-adenosyl-L-methionine; via amide
FT                                nitrogen. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01026}.
FT   BINDING      40     40       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01026}.
FT   BINDING      61     61       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01026}.
FT   BINDING      83     83       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01026}.
FT   BINDING      99     99       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01026}.
SQ   SEQUENCE   253 AA;  28125 MW;  160A507B9B63D1BC CRC64;
     MPTYRGGRHE HGQNFLTDRR IIASILNIIA ESDGPILEIG PGAGALTVPL ANLGRPLTVV
     EIDEKYVHAL RRTRLDATIV HGDFLRHRLP DEPATVVGNL PFHLTTAILR KLLHAPHWTD
     AVLITQWEVA RRRAGVGGST LMTAQWLPWY EFRLIRRLPA TAFTPRPGVD AGLLTVTRRP
     DPLMPWSARR AYAAFAHAVF TGRGRGLAAI LAGITRRDRA TVERWVAAQG WRGAPLPRDL
     DAAQWVDAFT RFG
//

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