(data stored in ACNUC1104 zone)

SWISSPROT: D5UST9_TSUPD

ID   D5UST9_TSUPD            Unreviewed;       261 AA.
AC   D5UST9;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   13-FEB-2019, entry version 50.
DE   SubName: Full=DNA glycosylase/AP lyase, H2TH DNA-binding protein {ECO:0000313|EMBL:ADG77226.1};
GN   OrderedLocusNames=Tpau_0588 {ECO:0000313|EMBL:ADG77226.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG77226.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG77226.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in
CC         DNA is broken by a beta-elimination reaction, leaving a 3'-
CC         terminal unsaturated sugar and a product with a terminal 5'-
CC         phosphate.; EC=4.2.99.18;
CC         Evidence={ECO:0000256|SAAS:SAAS01121890};
CC   -!- SIMILARITY: Belongs to the FPG family.
CC       {ECO:0000256|SAAS:SAAS00557294}.
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DR   EMBL; CP001966; ADG77226.1; -; Genomic_DNA.
DR   RefSeq; WP_013125268.1; NC_014158.1.
DR   STRING; 521096.Tpau_0588; -.
DR   EnsemblBacteria; ADG77226; ADG77226; Tpau_0588.
DR   KEGG; tpr:Tpau_0588; -.
DR   eggNOG; ENOG4108S0J; Bacteria.
DR   eggNOG; COG0266; LUCA.
DR   HOGENOM; HOG000020880; -.
DR   KO; K05522; -.
DR   OMA; EILWQAQ; -.
DR   OrthoDB; 1162346at2; -.
DR   BioCyc; TPAU521096:G1GKO-569-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   Gene3D; 3.20.190.10; -; 1.
DR   InterPro; IPR015886; DNA_glyclase/AP_lyase_DNA-bd.
DR   InterPro; IPR012319; FPG_cat.
DR   InterPro; IPR035937; MutM-like_N-ter.
DR   InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR   InterPro; IPR000214; Znf_DNA_glyclase/AP_lyase.
DR   Pfam; PF01149; Fapy_DNA_glyco; 1.
DR   Pfam; PF06831; H2TH; 1.
DR   SMART; SM00898; Fapy_DNA_glyco; 1.
DR   SMART; SM01232; H2TH; 1.
DR   SUPFAM; SSF46946; SSF46946; 1.
DR   SUPFAM; SSF81624; SSF81624; 1.
DR   PROSITE; PS51068; FPG_CAT; 1.
DR   PROSITE; PS51066; ZF_FPG_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5UST9.
DR   SWISS-2DPAGE; D5UST9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   DNA damage {ECO:0000256|SAAS:SAAS01087016};
KW   DNA repair {ECO:0000256|SAAS:SAAS01087019};
KW   DNA-binding {ECO:0000256|SAAS:SAAS01087047,
KW   ECO:0000313|EMBL:ADG77226.1};
KW   Glycosidase {ECO:0000256|SAAS:SAAS01087011};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01087030};
KW   Lyase {ECO:0000256|SAAS:SAAS01087025, ECO:0000313|EMBL:ADG77226.1};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00551678};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS01087023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Zinc {ECO:0000256|SAAS:SAAS00551670};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00391,
KW   ECO:0000256|SAAS:SAAS00551733}.
FT   DOMAIN        2    128       FPG_CAT. {ECO:0000259|PROSITE:PS51068}.
FT   DOMAIN      220    259       FPG-type. {ECO:0000259|PROSITE:PS51066}.
SQ   SEQUENCE   261 AA;  28255 MW;  E022C075A7384B62 CRC64;
     MPEGDTLHNL AARLRPVLAG RVLTGCDLRV PRYATVDLTG RTVDDVSARG KHLLIAAGDL
     TLHSHLKMEG QWHVYRPGER WRRPGHTARA VLAVDGAQVV GFSLGFLEVL RTAAVDDALA
     HLGPDPLGPQ WDPERAAENL AATPARPVGL ALLDQRNLAG IGNVYRNELC FVRGVHPAME
     VAACGDLRGW VDDAARLLRA NAGRSVRVTT GVDRNGLRAF VYDRARRPCL RCGTAISAGS
     LGADGEAERT IWWCPRCQDA N
//

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