(data stored in ACNUC7421 zone)

SWISSPROT: D6ZAD2_SEGRD

ID   D6ZAD2_SEGRD            Unreviewed;       442 AA.
AC   D6ZAD2;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN   OrderedLocusNames=Srot_0185 {ECO:0000313|EMBL:ADG96674.1};
OS   Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 /
OS   DSM 44985 / JCM 13578).
OC   Bacteria; Actinobacteria; Corynebacteriales; Segniliparaceae;
OC   Segniliparus.
OX   NCBI_TaxID=640132 {ECO:0000313|EMBL:ADG96674.1, ECO:0000313|Proteomes:UP000002247};
RN   [1] {ECO:0000313|EMBL:ADG96674.1, ECO:0000313|Proteomes:UP000002247}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578
RC   {ECO:0000313|Proteomes:UP000002247};
RX   PubMed=21304703; DOI=10.4056/sigs.791633;
RA   Sikorski J., Lapidus A., Copeland A., Misra M., Glavina Del Rio T.,
RA   Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Jando M.,
RA   Schneider S., Bruce D., Goodwin L., Pitluck S., Liolios K.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chertkov O., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Detter J.C., Han C., Rohde M., Goker M.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Segniliparus rotundus type strain (CDC
RT   1076).";
RL   Stand. Genomic Sci. 2:203-211(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|RuleBase:RU003370};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       isocitrate from oxaloacetate: step 1/2.
CC       {ECO:0000256|RuleBase:RU003370}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003406}.
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DR   EMBL; CP001958; ADG96674.1; -; Genomic_DNA.
DR   STRING; 640132.Srot_0185; -.
DR   EnsemblBacteria; ADG96674; ADG96674; Srot_0185.
DR   KEGG; srt:Srot_0185; -.
DR   eggNOG; ENOG4105BZN; Bacteria.
DR   eggNOG; COG0372; LUCA.
DR   HOGENOM; HOG000021224; -.
DR   KO; K01647; -.
DR   OMA; TVGWCAQ; -.
DR   BioCyc; SROT640132:G1GLH-189-MONOMER; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000002247; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6ZAD2.
DR   SWISS-2DPAGE; D6ZAD2.
KW   Acyltransferase {ECO:0000313|EMBL:ADG96674.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002247};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002247};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369,
KW   ECO:0000256|RuleBase:RU003370, ECO:0000313|EMBL:ADG96674.1};
KW   Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU003370}.
FT   ACT_SITE    319    319       {ECO:0000256|PIRSR:PIRSR001369-1}.
FT   ACT_SITE    376    376       {ECO:0000256|PIRSR:PIRSR001369-1}.
SQ   SEQUENCE   442 AA;  49114 MW;  FCC99E087ABA8808 CRC64;
     MSVAQPAERT DQNAVGAATL RYPGGEKELT VTPAVEGNAG VQLGDLLAST GYVTYDEGFM
     NTASTKSAIT YIDGEHGILR YRGYPIDQLA QKSTFLEVSY LLIYGELPTA AQLEEFAHKI
     SRHTMLHEDL KRFFDGFPRD AHPMPVLSSA VNALSAYYPD SVDPSDPAQV EQSTLRLLAK
     LPTIAAYAYK KSVGQPFLYP DNSLNLVENF LRMTFGFPAE PYDIDPNVVK ALDMLFILHA
     DHEQNCSTST VRLVGSSNAN LFTSVSGGIN ALWGPLHGGA NQAVLEMLDQ IKASGESASD
     FLAKVKDKKT RIKLMGFGHR VYRNYDPRAA IVKQTADQIL NQLKVTDELL DIAKELEQAA
     LTDEYFVSRK LYPNVDFYTG LIYRAMGFPD RMFTVLFALG RLPGWIAHWR EMHDSGPLKI
     GRPRQIYTGQ PERPYVSLTD RV
//

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