(data stored in ACNUC7421 zone)

SWISSPROT: D6ZCQ1_SEGRD

ID   D6ZCQ1_SEGRD            Unreviewed;       650 AA.
AC   D6ZCQ1;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203, ECO:0000256|SAAS:SAAS00125834};
DE            Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=Srot_0611 {ECO:0000313|EMBL:ADG97093.1};
OS   Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 /
OS   DSM 44985 / JCM 13578).
OC   Bacteria; Actinobacteria; Corynebacteriales; Segniliparaceae;
OC   Segniliparus.
OX   NCBI_TaxID=640132 {ECO:0000313|EMBL:ADG97093.1, ECO:0000313|Proteomes:UP000002247};
RN   [1] {ECO:0000313|EMBL:ADG97093.1, ECO:0000313|Proteomes:UP000002247}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578
RC   {ECO:0000313|Proteomes:UP000002247};
RX   PubMed=21304703; DOI=10.4056/sigs.791633;
RA   Sikorski J., Lapidus A., Copeland A., Misra M., Glavina Del Rio T.,
RA   Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Jando M.,
RA   Schneider S., Bruce D., Goodwin L., Pitluck S., Liolios K.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chertkov O., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Detter J.C., Han C., Rohde M., Goker M.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Segniliparus rotundus type strain (CDC
RT   1076).";
RL   Stand. Genomic Sci. 2:203-211(2010).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC       of the lesion. The N-terminal half is responsible for the 3'
CC       incision and the C-terminal half is responsible for the 5'
CC       incision. {ECO:0000256|HAMAP-Rule:MF_00203,
CC       ECO:0000256|SAAS:SAAS00088192}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000256|HAMAP-Rule:MF_00203, ECO:0000256|SAAS:SAAS00125843}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203,
CC       ECO:0000256|SAAS:SAAS00088142}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC       Rule:MF_00203, ECO:0000256|SAAS:SAAS00571147}.
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DR   EMBL; CP001958; ADG97093.1; -; Genomic_DNA.
DR   STRING; 640132.Srot_0611; -.
DR   EnsemblBacteria; ADG97093; ADG97093; Srot_0611.
DR   KEGG; srt:Srot_0611; -.
DR   eggNOG; ENOG4105CII; Bacteria.
DR   eggNOG; COG0322; LUCA.
DR   HOGENOM; HOG000279962; -.
DR   KO; K03703; -.
DR   OMA; LFPIRQC; -.
DR   Proteomes; UP000002247; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   InterPro; IPR038476; UvrC_homol_region_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6ZCQ1.
DR   SWISS-2DPAGE; D6ZCQ1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002247};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203,
KW   ECO:0000256|SAAS:SAAS00125861};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00203,
KW   ECO:0000256|SAAS:SAAS00460887};
KW   DNA excision {ECO:0000256|HAMAP-Rule:MF_00203,
KW   ECO:0000256|SAAS:SAAS00460890};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00203,
KW   ECO:0000256|SAAS:SAAS00480870};
KW   Excision nuclease {ECO:0000256|HAMAP-Rule:MF_00203,
KW   ECO:0000256|SAAS:SAAS00511323};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002247};
KW   SOS response {ECO:0000256|HAMAP-Rule:MF_00203,
KW   ECO:0000256|SAAS:SAAS01153619}.
FT   DOMAIN       12     91       GIY-YIG. {ECO:0000259|PROSITE:PS50164}.
FT   DOMAIN      204    239       UVR. {ECO:0000259|PROSITE:PS50151}.
FT   DOMAIN      255    519       UVRC. {ECO:0000259|PROSITE:PS50165}.
SQ   SEQUENCE   650 AA;  72219 MW;  B32E75EF0A287CAE CRC64;
     MSYRPAAGAI PTEPGVYRFR DPSGQVIYVG KAKNLRARLS NYFQDLYALA PRTRLMVTTA
     SAVEWTVVAT EVEALQLEFS WIKEFDPRFN VRYRDDKSYP MLAVSLNEEY PRLFVYRGAR
     RKGVRYFGPY SHVWAIRNTV DLLTKVFPAR TCSNGVFKRH GQIGRPCLLG YIDKCSAPCV
     GAVSAAEHRR IVQSFCEFLA GGADNLVRET RKRMLAAAEA LDFEAAARLR DELAALDKAL
     EHQTVVLADG SDADVVAFDY DELEVAVQVF QVREGRVRGQ RGWVVDNAYS PGPHGDRTRD
     GRGWEAASRR EMVEEFLLQF YGDLAELESV ADRFGQSDRM SAVPKEVLVP ELPDDVEGFA
     TWLSTLRGTP VALRVPRRGD KRKLMETVAR NAHETLAQHK LRRSGDFTER SAALQEIYEA
     FDLPAPPIRI ECVDVSHVQG TDVVASLVVF DDGLPKKADY RHYTIKGAMG ADGAPQNDDT
     RSVAEVIARR FAKRGDRPDP GLLVIDGGQP QVRAAHKALV ELGAADIPVV GLAKRLEELW
     LPDDDDPVIL PRRSPGLFLL QRVRDEAHRF AIAHHRKKRS KRMTVSALDE VKGLGERRRA
     QLVKHFGSVR KLADASADEI AALPGFGPVL AESVVTALAA CQTPPQEASA
//

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