(data stored in ACNUC7421 zone)

SWISSPROT: D6ZCR7_SEGRD

ID   D6ZCR7_SEGRD            Unreviewed;        92 AA.
AC   D6ZCR7;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   RecName: Full=Transcriptional regulator WhiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   Name=whiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   OrderedLocusNames=Srot_0627 {ECO:0000313|EMBL:ADG97109.1};
OS   Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 /
OS   DSM 44985 / JCM 13578).
OC   Bacteria; Actinobacteria; Corynebacteriales; Segniliparaceae;
OC   Segniliparus.
OX   NCBI_TaxID=640132 {ECO:0000313|EMBL:ADG97109.1, ECO:0000313|Proteomes:UP000002247};
RN   [1] {ECO:0000313|EMBL:ADG97109.1, ECO:0000313|Proteomes:UP000002247}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578
RC   {ECO:0000313|Proteomes:UP000002247};
RX   PubMed=21304703; DOI=10.4056/sigs.791633;
RA   Sikorski J., Lapidus A., Copeland A., Misra M., Glavina Del Rio T.,
RA   Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Jando M.,
RA   Schneider S., Bruce D., Goodwin L., Pitluck S., Liolios K.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chertkov O., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Detter J.C., Han C., Rohde M., Goker M.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Segniliparus rotundus type strain (CDC
RT   1076).";
RL   Stand. Genomic Sci. 2:203-211(2010).
CC   -!- FUNCTION: Acts as a transcriptional regulator. Probably redox-
CC       responsive. The apo- but not holo-form probably binds DNA.
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01479};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation
CC       of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_01479};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: Upon Fe-S cluster removal intramolecular disulfide bonds are
CC       formed. {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- SIMILARITY: Belongs to the WhiB family. {ECO:0000256|HAMAP-
CC       Rule:MF_01479}.
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DR   EMBL; CP001958; ADG97109.1; -; Genomic_DNA.
DR   RefSeq; WP_013137565.1; NC_014168.1.
DR   STRING; 640132.Srot_0627; -.
DR   EnsemblBacteria; ADG97109; ADG97109; Srot_0627.
DR   KEGG; srt:Srot_0627; -.
DR   eggNOG; ENOG4105K51; Bacteria.
DR   eggNOG; ENOG4111TPB; LUCA.
DR   HOGENOM; HOG000247630; -.
DR   KO; K18955; -.
DR   OMA; CEVRDEC; -.
DR   OrthoDB; 1908599at2; -.
DR   BioCyc; SROT640132:G1GLH-633-MONOMER; -.
DR   Proteomes; UP000002247; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0035731; F:dinitrosyl-iron complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01479; WhiB; 1.
DR   InterPro; IPR034768; 4FE4S_WBL.
DR   InterPro; IPR003482; Whib.
DR   PANTHER; PTHR38839; PTHR38839; 1.
DR   Pfam; PF02467; Whib; 1.
DR   PROSITE; PS51674; 4FE4S_WBL; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6ZCR7.
DR   SWISS-2DPAGE; D6ZCR7.
KW   4Fe-4S {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002247};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Disulfide bond {ECO:0000256|HAMAP-Rule:MF_01479};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002247};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   DOMAIN       29     86       4Fe-4S Wbl-type. {ECO:0000259|PROSITE:
FT                                PS51674}.
FT   METAL        30     30       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        30     30       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        53     53       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        53     53       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        56     56       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        56     56       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        62     62       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        62     62       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
SQ   SEQUENCE   92 AA;  10604 MW;  86AB91FA9F1F9E44 CRC64;
     MKDSLDITQQ IFLAIAEEEG AGQWQENALC AQTDPEVFFP EKGGSTREAK RICLNCEVKN
     DCLEFALQND ERFGIWGGLS ERERRRLRRR LA
//

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