(data stored in ACNUC1104 zone)

SWISSPROT: D6ZZY8_STAND

ID   D6ZZY8_STAND            Unreviewed;       363 AA.
AC   D6ZZY8;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   RecName: Full=Dihydroorotate dehydrogenase (quinone) {ECO:0000256|SAAS:SAAS00767036};
DE            EC=1.3.5.2 {ECO:0000256|SAAS:SAAS00767036};
GN   OrderedLocusNames=Snov_0065 {ECO:0000313|EMBL:ADH87402.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87402.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87402.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- FUNCTION: Catalyzes the conversion of dihydroorotate to orotate
CC       with quinone as electron acceptor.
CC       {ECO:0000256|SAAS:SAAS00767022}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-dihydroorotate + a quinone = a quinol + orotate;
CC         Xref=Rhea:RHEA:30187, ChEBI:CHEBI:24646, ChEBI:CHEBI:30839,
CC         ChEBI:CHEBI:30864, ChEBI:CHEBI:132124; EC=1.3.5.2;
CC         Evidence={ECO:0000256|SAAS:SAAS01124321};
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|SAAS:SAAS00611625};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; orotate from (S)-dihydroorotate (quinone route): step
CC       1/1. {ECO:0000256|SAAS:SAAS00767035}.
CC   -!- SIMILARITY: Belongs to the dihydroorotate dehydrogenase family.
CC       Type 2 subfamily. {ECO:0000256|SAAS:SAAS00767034}.
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DR   EMBL; CP002026; ADH87402.1; -; Genomic_DNA.
DR   RefSeq; WP_013164907.1; NC_014217.1.
DR   STRING; 639283.Snov_0065; -.
DR   EnsemblBacteria; ADH87402; ADH87402; Snov_0065.
DR   KEGG; sno:Snov_0065; -.
DR   eggNOG; ENOG4107QYT; Bacteria.
DR   eggNOG; COG0167; LUCA.
DR   HOGENOM; HOG000225103; -.
DR   KO; K00254; -.
DR   OMA; ALNRMGF; -.
DR   OrthoDB; 1109542at2; -.
DR   BioCyc; SNOV639283:G1GLM-65-MONOMER; -.
DR   UniPathway; UPA00070; UER00946.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004152; F:dihydroorotate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04738; DHOD_2_like; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005720; Dihydroorotate_DH.
DR   InterPro; IPR005719; Dihydroorotate_DH_2.
DR   InterPro; IPR001295; Dihydroorotate_DH_CS.
DR   Pfam; PF01180; DHO_dh; 1.
DR   TIGRFAMs; TIGR01036; pyrD_sub2; 1.
DR   PROSITE; PS00911; DHODEHASE_1; 1.
DR   PROSITE; PS00912; DHODEHASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6ZZY8.
DR   SWISS-2DPAGE; D6ZZY8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   Flavoprotein {ECO:0000256|SAAS:SAAS00243575};
KW   FMN {ECO:0000256|SAAS:SAAS00459616};
KW   Membrane {ECO:0000256|SAAS:SAAS00767044};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00243616,
KW   ECO:0000313|EMBL:ADH87402.1};
KW   Pyrimidine biosynthesis {ECO:0000256|SAAS:SAAS00767026};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633}.
FT   DOMAIN       43    337       DHO_dh. {ECO:0000259|Pfam:PF01180}.
SQ   SEQUENCE   363 AA;  38475 MW;  EA36AFE40D4FD2A1 CRC64;
     MSALFDLALP FARLMDPENA HRLAIRALAC LPPRAPEPDD ARLKVEAFGL RFPNPVGLAA
     GFDKEAEVPD AMLGAGFGFV EVGTITPRPQ SGNPRPRNFR LTEDRAVINR YGFNSGGHGP
     AKARLIARKG KSRNSAGIVG VNVGANKETV DRAADYVAGI EAFAGLGDYF TVNVSSPNTP
     GLRDLQEETA LDDLLARCVE ARDRHAPGVP LLLKIAPDLA LPHLDGVVEV AHRRRVDGLI
     VSNTTISRPP GLRSPHKGET GGLSGRPLFA LSTRMLAETY VRADGAFPII GVGGIDSAET
     AFAKIEAGAS LIQLYSGLVY EGLGLVPRIK AGLLARLAKE HATLAEITGR RARQVVAEPF
     PGA
//

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