(data stored in ACNUC1104 zone)

SWISSPROT: D7A006_STAND

ID   D7A006_STAND            Unreviewed;       193 AA.
AC   D7A006;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 43.
DE   RecName: Full=dTDP-4-dehydrorhamnose 3,5-epimerase {ECO:0000256|RuleBase:RU364069};
DE            EC=5.1.3.13 {ECO:0000256|RuleBase:RU364069};
DE   AltName: Full=Thymidine diphospho-4-keto-rhamnose 3,5-epimerase {ECO:0000256|RuleBase:RU364069};
GN   OrderedLocusNames=Snov_0083 {ECO:0000313|EMBL:ADH87420.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87420.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87420.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- FUNCTION: Catalyzes the epimerization of the C3' and C5'positions
CC       of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-
CC       hexulose. {ECO:0000256|RuleBase:RU364069}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-
CC         beta-L-rhamnose; Xref=Rhea:RHEA:16969, ChEBI:CHEBI:57649,
CC         ChEBI:CHEBI:62830; EC=5.1.3.13;
CC         Evidence={ECO:0000256|RuleBase:RU364069};
CC   -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC       {ECO:0000256|RuleBase:RU364069}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU364069}.
CC   -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase
CC       family. {ECO:0000256|RuleBase:RU364069}.
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DR   EMBL; CP002026; ADH87420.1; -; Genomic_DNA.
DR   RefSeq; WP_013164925.1; NC_014217.1.
DR   STRING; 639283.Snov_0083; -.
DR   EnsemblBacteria; ADH87420; ADH87420; Snov_0083.
DR   KEGG; sno:Snov_0083; -.
DR   eggNOG; ENOG4108URP; Bacteria.
DR   eggNOG; COG1898; LUCA.
DR   HOGENOM; HOG000227724; -.
DR   KO; K01790; -.
DR   OMA; TEIIYKC; -.
DR   OrthoDB; 1618609at2; -.
DR   BioCyc; SNOV639283:G1GLM-83-MONOMER; -.
DR   UniPathway; UPA00124; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0008830; F:dTDP-4-dehydrorhamnose 3,5-epimerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR000888; dTDP_sugar_isom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR21047; PTHR21047; 1.
DR   Pfam; PF00908; dTDP_sugar_isom; 1.
DR   ProDom; PD001462; dTDP_sugar_isom; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR01221; rmlC; 1.
PE   3: Inferred from homology;
DR   PRODOM; D7A006.
DR   SWISS-2DPAGE; D7A006.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   Isomerase {ECO:0000256|RuleBase:RU364069,
KW   ECO:0000313|EMBL:ADH87420.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633}.
SQ   SEQUENCE   193 AA;  21325 MW;  943E8493D6DACA1D CRC64;
     MVAFTRLAIP DVVLVQPVRH GDGRGYFCET YKKPAFDAFG IDLAFVQDNE SLSRPVGVVR
     GLHFQTPPMA QAKLVRVLRG AIFDVAVDIR RGSPSYGKWV AATLTAEEGN QLFMPHGFAH
     GFCTLEPDTL IAYKVDAPYS RPNDAGIAWD DPDLAIDWPV TTETAVLSDK DRVQPRLRDY
     ASPFAYAPET VRA
//

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