(data stored in ACNUC1104 zone)

SWISSPROT: D7A0S6_STAND

ID   D7A0S6_STAND            Unreviewed;       422 AA.
AC   D7A0S6;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 48.
DE   SubName: Full=GTP cyclohydrolase II {ECO:0000313|EMBL:ADH87436.1};
GN   OrderedLocusNames=Snov_0099 {ECO:0000313|EMBL:ADH87436.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87436.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87436.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-
CC         phosphoribosylamino)-pyrimidine + diphosphate + formate + 2
CC         H(+); Xref=Rhea:RHEA:23704, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:37565, ChEBI:CHEBI:58614; EC=3.5.4.25;
CC         Evidence={ECO:0000256|SAAS:SAAS01116087};
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-
CC       6-(D-ribitylamino)uracil from GTP.
CC       {ECO:0000256|SAAS:SAAS00711745}.
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DR   EMBL; CP002026; ADH87436.1; -; Genomic_DNA.
DR   RefSeq; WP_013164941.1; NC_014217.1.
DR   STRING; 639283.Snov_0099; -.
DR   EnsemblBacteria; ADH87436; ADH87436; Snov_0099.
DR   KEGG; sno:Snov_0099; -.
DR   eggNOG; ENOG4105TCV; Bacteria.
DR   eggNOG; COG0807; LUCA.
DR   HOGENOM; HOG000077582; -.
DR   OMA; SFDPWGH; -.
DR   OrthoDB; 900513at2; -.
DR   BioCyc; SNOV639283:G1GLM-99-MONOMER; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00641; GTP_cyclohydro2; 1.
DR   Gene3D; 3.40.50.10990; -; 1.
DR   InterPro; IPR022163; GTP_CH_N.
DR   InterPro; IPR032677; GTP_cyclohydro_II.
DR   InterPro; IPR000926; RibA.
DR   InterPro; IPR036144; RibA-like_sf.
DR   Pfam; PF12471; GTP_CH_N; 1.
DR   Pfam; PF00925; GTP_cyclohydro2; 1.
DR   SUPFAM; SSF142695; SSF142695; 1.
PE   4: Predicted;
DR   PRODOM; D7A0S6.
DR   SWISS-2DPAGE; D7A0S6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   GTP-binding {ECO:0000256|SAAS:SAAS00711691};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01033620,
KW   ECO:0000313|EMBL:ADH87436.1};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00711702};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00711707};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633};
KW   Riboflavin biosynthesis {ECO:0000256|SAAS:SAAS00711711}.
FT   DOMAIN       13    204       GTP_CH_N. {ECO:0000259|Pfam:PF12471}.
FT   DOMAIN      234    381       GTP_cyclohydro2. {ECO:0000259|Pfam:
FT                                PF00925}.
SQ   SEQUENCE   422 AA;  45325 MW;  5697E988A5A39ECB CRC64;
     MSVNANAGGR SRNHIVLTSH GAPTGVAADA PSLNWGAPTP AERGPVVATL TDPKRRNAIG
     AHAGGYSVYR ALAIAAGALP ADFRADLTNT APSDAIGPHP QWGDPKAIVS LDPYGHMVGE
     AFAGEIAAGL DVRPTIAITR AHIDMPEIRD AIRAGRLAID GDIIGPKGDV RVTKAAIEPV
     WYLPGIAERF GVSEGALRRA LFEHTGGMFP ELVTRGDLKV FLPPIGGMTL YMFGDPSKIG
     DGITPLACRV HDECNGSDVF SSDICTCRPY LAHGIEICVE MAQKGGVGLV VYNRKEGRAL
     GEVTKFLVYN ARKRQEGGDL PETYFKRTEC VAGVQDMRFQ ELMPDVFHWL GIKRIDRFAS
     MSDMKFNALA RAGIEVVERV PIPDELIPSD ARVEMEAKVS AGYYGVGFQS QFDATQGRAL
     EE
//

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