(data stored in ACNUC1104 zone)

SWISSPROT: D7A0V2_STAND

ID   D7A0V2_STAND            Unreviewed;        73 AA.
AC   D7A0V2;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 52.
DE   RecName: Full=DNA gyrase inhibitor YacG {ECO:0000256|HAMAP-Rule:MF_00649, ECO:0000256|SAAS:SAAS00382377};
GN   Name=yacG {ECO:0000256|HAMAP-Rule:MF_00649};
GN   OrderedLocusNames=Snov_0125 {ECO:0000313|EMBL:ADH87462.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87462.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87462.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- FUNCTION: Inhibits all the catalytic activities of DNA gyrase by
CC       preventing its interaction with DNA. Acts by binding directly to
CC       the C-terminal domain of GyrB, which probably disrupts DNA binding
CC       by the gyrase. {ECO:0000256|HAMAP-Rule:MF_00649,
CC       ECO:0000256|SAAS:SAAS00085449}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00649};
CC       Note=Binds 1 zinc ion. {ECO:0000256|HAMAP-Rule:MF_00649};
CC   -!- SUBUNIT: Interacts with GyrB. {ECO:0000256|HAMAP-Rule:MF_00649,
CC       ECO:0000256|SAAS:SAAS00085444}.
CC   -!- SIMILARITY: Belongs to the DNA gyrase inhibitor YacG family.
CC       {ECO:0000256|HAMAP-Rule:MF_00649, ECO:0000256|SAAS:SAAS00570156}.
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DR   EMBL; CP002026; ADH87462.1; -; Genomic_DNA.
DR   RefSeq; WP_013164967.1; NC_014217.1.
DR   STRING; 639283.Snov_0125; -.
DR   EnsemblBacteria; ADH87462; ADH87462; Snov_0125.
DR   KEGG; sno:Snov_0125; -.
DR   eggNOG; ENOG4105VYE; Bacteria.
DR   eggNOG; ENOG410XUEH; LUCA.
DR   HOGENOM; HOG000255917; -.
DR   KO; K09862; -.
DR   OMA; CSNRCRE; -.
DR   OrthoDB; 2071775at2; -.
DR   BioCyc; SNOV639283:G1GLM-126-MONOMER; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0008657; F:DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.30.50.10; -; 1.
DR   HAMAP; MF_00649; DNA_gyrase_inhibitor_YacG; 1.
DR   InterPro; IPR005584; DNA_gyrase_inhibitor_YacG.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR36150; PTHR36150; 1.
DR   Pfam; PF03884; YacG; 1.
PE   3: Inferred from homology;
DR   PRODOM; D7A0V2.
DR   SWISS-2DPAGE; D7A0V2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00649,
KW   ECO:0000256|SAAS:SAAS00459510};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00649, ECO:0000256|SAAS:SAAS00459506}.
FT   METAL        16     16       Zinc. {ECO:0000256|HAMAP-Rule:MF_00649}.
FT   METAL        19     19       Zinc. {ECO:0000256|HAMAP-Rule:MF_00649}.
FT   METAL        31     31       Zinc. {ECO:0000256|HAMAP-Rule:MF_00649}.
FT   METAL        35     35       Zinc. {ECO:0000256|HAMAP-Rule:MF_00649}.
SQ   SEQUENCE   73 AA;  7825 MW;  BD1F76820B9D8A92 CRC64;
     MSADAPSSAD KNTGTCPICG KPSVEKYKPF CSSRCADVDL HRWLTGAYAI PVTEDDDEDG
     EEPSLAPKPP RKA
//

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