(data stored in ACNUC1104 zone)

SWISSPROT: D7A1X0_STAND

ID   D7A1X0_STAND            Unreviewed;       251 AA.
AC   D7A1X0;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   RecName: Full=3-deoxy-manno-octulosonate cytidylyltransferase {ECO:0000256|HAMAP-Rule:MF_00057};
DE            EC=2.7.7.38 {ECO:0000256|HAMAP-Rule:MF_00057};
DE   AltName: Full=CMP-2-keto-3-deoxyoctulosonic acid synthase {ECO:0000256|HAMAP-Rule:MF_00057};
DE            Short=CKS {ECO:0000256|HAMAP-Rule:MF_00057};
DE            Short=CMP-KDO synthase {ECO:0000256|HAMAP-Rule:MF_00057};
GN   Name=kdsB {ECO:0000256|HAMAP-Rule:MF_00057};
GN   OrderedLocusNames=Snov_0251 {ECO:0000313|EMBL:ADH87586.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87586.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87586.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- FUNCTION: Activates KDO (a required 8-carbon sugar) for
CC       incorporation into bacterial lipopolysaccharide in Gram-negative
CC       bacteria. {ECO:0000256|HAMAP-Rule:MF_00057}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-
CC         deoxy-beta-D-manno-octulosonate + diphosphate;
CC         Xref=Rhea:RHEA:23448, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC         ChEBI:CHEBI:85986, ChEBI:CHEBI:85987; EC=2.7.7.38;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00057};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis. {ECO:0000256|HAMAP-Rule:MF_00057,
CC       ECO:0000256|SAAS:SAAS00089002}.
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-
CC       octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from
CC       3-deoxy-D-manno-octulosonate and CTP: step 1/1.
CC       {ECO:0000256|HAMAP-Rule:MF_00057}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00057,
CC       ECO:0000256|SAAS:SAAS00384950}.
CC   -!- SIMILARITY: Belongs to the KdsB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00057, ECO:0000256|SAAS:SAAS00571408}.
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DR   EMBL; CP002026; ADH87586.1; -; Genomic_DNA.
DR   STRING; 639283.Snov_0251; -.
DR   EnsemblBacteria; ADH87586; ADH87586; Snov_0251.
DR   KEGG; sno:Snov_0251; -.
DR   eggNOG; ENOG4105CET; Bacteria.
DR   eggNOG; COG1212; LUCA.
DR   HOGENOM; HOG000007602; -.
DR   KO; K00979; -.
DR   OMA; FMATCAK; -.
DR   BioCyc; SNOV639283:G1GLM-253-MONOMER; -.
DR   UniPathway; UPA00030; -.
DR   UniPathway; UPA00358; UER00476.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008690; F:3-deoxy-manno-octulosonate cytidylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0033468; P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02517; CMP-KDO-Synthetase; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   HAMAP; MF_00057; KdsB; 1.
DR   InterPro; IPR003329; Cytidylyl_trans.
DR   InterPro; IPR004528; KdsB.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF02348; CTP_transf_3; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR00466; kdsB; 1.
PE   3: Inferred from homology;
DR   PRODOM; D7A1X0.
DR   SWISS-2DPAGE; D7A1X0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00057,
KW   ECO:0000256|SAAS:SAAS00097217};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00057,
KW   ECO:0000256|SAAS:SAAS00461675};
KW   Nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_00057,
KW   ECO:0000256|SAAS:SAAS00461736, ECO:0000313|EMBL:ADH87586.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00057,
KW   ECO:0000256|SAAS:SAAS00088998, ECO:0000313|EMBL:ADH87586.1}.
SQ   SEQUENCE   251 AA;  27107 MW;  4F783768D9FC4A9B CRC64;
     MSSQDTLILI PARMASTRLP GKPLADLGGR PMIVEVARRS AAANIGRVVV ATDDEGVRKA
     VENAGFAVVM TRADHTTGSD RIFEALGHVD PERRVSRIVN VQGDLPTIDP ALIRSAVDLL
     DDPAVDIGTL AAQITVEAER TNPNVVKAVG SPLSPSRLRA LYFTRATAPY GEGPLFHHIG
     LYAYRRAALE RFVALPPSPL ESREKLEQLR ALEAGMRIDV AIVDTVPLGV DTPEDLERAR
     ELLAREAKTA K
//

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