(data stored in ACNUC1104 zone)

SWISSPROT: D7A251_STAND

ID   D7A251_STAND            Unreviewed;       611 AA.
AC   D7A251;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 60.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149, ECO:0000256|SAAS:SAAS01158470};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Snov_0333 {ECO:0000313|EMBL:ADH87667.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87667.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87667.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in
CC       DNA. It is required for dam-dependent methyl-directed DNA mismatch
CC       repair. May act as a "molecular matchmaker", a protein that
CC       promotes the formation of a stable complex between two or more
CC       DNA-binding proteins in an ATP-dependent manner without itself
CC       being part of a final effector complex. {ECO:0000256|HAMAP-
CC       Rule:MF_00149, ECO:0000256|SAAS:SAAS01158472}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00149, ECO:0000256|SAAS:SAAS01076587}.
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DR   EMBL; CP002026; ADH87667.1; -; Genomic_DNA.
DR   RefSeq; WP_013165172.1; NC_014217.1.
DR   STRING; 639283.Snov_0333; -.
DR   EnsemblBacteria; ADH87667; ADH87667; Snov_0333.
DR   KEGG; sno:Snov_0333; -.
DR   eggNOG; ENOG4105DC6; Bacteria.
DR   eggNOG; COG0323; LUCA.
DR   HOGENOM; HOG000256550; -.
DR   KO; K03572; -.
DR   OMA; QHIAHER; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; SNOV639283:G1GLM-337-MONOMER; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00075; HATPase_c; 1.
DR   Gene3D; 2.30.42.20; -; 1.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; D7A251.
DR   SWISS-2DPAGE; D7A251.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00149,
KW   ECO:0000256|SAAS:SAAS00440831};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00149,
KW   ECO:0000256|SAAS:SAAS00020747};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633}.
FT   DOMAIN      211    329       DNA_mis_repair. {ECO:0000259|SMART:
FT                                SM01340}.
FT   DOMAIN      425    568       MutL_C. {ECO:0000259|SMART:SM00853}.
SQ   SEQUENCE   611 AA;  65428 MW;  182B8EFAEFCBC365 CRC64;
     MPLRLLPSTL VDRIAAGEVV ERPAAALKEI VENALDAGAT RIEVVIDGGG RRLMRVTDDG
     CGMSADELAL AVERHATSKL DTEDLLSIAT LGFRGEALPS IGAVARLSIT SRPRGSDTAH
     EIRVEGGAKS AVKPAALGFG TRVEVRDLFF ATPARLKFLK SERAETAAAV DAVKRLALAR
     PDVGFILVTD DRPPVTWPAR SADAAGRRAR IADVLGHEVG ANALDIDGLR EGARLSGLAG
     LPTYAKANSL SQYLFVNGRP VRDKVLIGAI RAAYADLLPS DRHPVTALFL DLDPHEVDVN
     VHPAKTEVRF RDAGNVRALI VRTLTDALAL GVPRTASTAA EKLAQFARPE FRQGAGNPPR
     PGNYDWTRSW AAPDVAPREA SPAGFREEAA GFDFGLGLAL APSADARANA APPAPDLMER
     PLGAARAQLH ETYIIAQTKD GVVVIDQHAA HERIVYEKLK AAMERDGLAR QMLLVPLVVE
     LDPSDAARLA ERAAALEKLG LVLEPFGPGA VLVREVPSLL GDADVCALVT ELAEHAAEWD
     DALPLERRLL HIAATMACHG SVRAGRRLRV EEMNALLREM EETPNAAQCN HGRPTFVTLA
     LADIERLFAR R
//

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