(data stored in ACNUC1104 zone)

SWISSPROT: D7A484_STAND

ID   D7A484_STAND            Unreviewed;       563 AA.
AC   D7A484;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=Thiamine pyrophosphate protein domain protein TPP-binding protein {ECO:0000313|EMBL:ADH87904.1};
GN   OrderedLocusNames=Snov_0571 {ECO:0000313|EMBL:ADH87904.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87904.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87904.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP002026; ADH87904.1; -; Genomic_DNA.
DR   RefSeq; WP_013165409.1; NC_014217.1.
DR   STRING; 639283.Snov_0571; -.
DR   EnsemblBacteria; ADH87904; ADH87904; Snov_0571.
DR   KEGG; sno:Snov_0571; -.
DR   eggNOG; ENOG4105C7K; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000258445; -.
DR   KO; K01652; -.
DR   OMA; ATWVHRF; -.
DR   OrthoDB; 391134at2; -.
DR   BioCyc; SNOV639283:G1GLM-576-MONOMER; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
PE   3: Inferred from homology;
DR   PRODOM; D7A484.
DR   SWISS-2DPAGE; D7A484.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN       11    177       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      198    333       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      390    536       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   563 AA;  60364 MW;  C3FCA0EF536F949F CRC64;
     MNAAHSPSAR TGAHLLVDAL IANGVTRAFG VPGESYLDVL DALSDTEVDF VVCRQEGGAA
     MMAEASGKLT GRPGICFVTR GPGATNASAG VHIAQQDSTP MILFVGQISR SMRGREAFQE
     VDYRAVFGTL AKWAVEIDEA ARIPEIIARA FRVAMQGRPG PVVIALPEDV LSEYADVPDA
     PPVEPAETWP GLTDMMRLQK LLWEAERPIM IVGGTRWNPK AVAALVRFAE RCDLPVAVSF
     RRQMLFPADH PCYAGDVGLG INPKLVGRLK EADLVIVAGG RLGEVPSQGY SLFPIPDPGV
     PFVHVHAEAD ELGRVYQPTL AINASNAAFA AALEGVQPPH VVPWDDWREA VRDDYLAWTE
     EPPANPGAVQ MATLVRYLRA LPDDTTICNG AGNFATWVHR FHRFRAYGTQ LAPTSGSMGY
     GFPAAVAAKR AHPERTVVAV CGDGDFLMTG QEFATAVQYG IPVIAVVIDN GMYGTIRMHQ
     EREFPTRVYG TALKNPDFAA YARAFGGFGV TVETDAEFTP ALEAALAAGL PAVVHVKLDP
     EAITPTMTLS ALREKALADR SVG
//

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