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ID D6XV49_BACIE Unreviewed; 1186 AA.
AC D6XV49;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 08-MAY-2019, entry version 71.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN OrderedLocusNames=Bsel_0056 {ECO:0000313|EMBL:ADH97607.1};
OS Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Sporolactobacillaceae;
OC unclassified Sporolactobacillaceae.
OX NCBI_TaxID=439292 {ECO:0000313|EMBL:ADH97607.1, ECO:0000313|Proteomes:UP000000271};
RN [1] {ECO:0000313|EMBL:ADH97607.1, ECO:0000313|Proteomes:UP000000271}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700615 / DSM 15326 / MLS10
RC {ECO:0000313|Proteomes:UP000000271};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Ovchinnikova G., Stolz J.;
RT "Complete sequence of Bacillus selenitireducens MLS10.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969,
CC ECO:0000256|SAAS:SAAS01144535}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase
CC family. RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP001791; ADH97607.1; -; Genomic_DNA.
DR RefSeq; WP_013171037.1; NC_014219.1.
DR STRING; 439292.Bsel_0056; -.
DR EnsemblBacteria; ADH97607; ADH97607; Bsel_0056.
DR KEGG; bse:Bsel_0056; -.
DR eggNOG; ENOG4108JA2; Bacteria.
DR eggNOG; COG1197; LUCA.
DR HOGENOM; HOG000216591; -.
DR KO; K03723; -.
DR OMA; LDIPRVN; -.
DR OrthoDB; 234717at2; -.
DR BioCyc; BSEL439292:G1GLR-63-MONOMER; -.
DR Proteomes; UP000000271; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd00079; HELICc; 1.
DR Gene3D; 2.30.30.840; -; 1.
DR Gene3D; 3.90.1150.50; -; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR036101; CarD-like/TRCF_dom_sf.
DR InterPro; IPR003711; CarD-like/TRCF_domain.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR037235; TRCF-like_C.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR Pfam; PF02559; CarD_CdnL_TRCF; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; SSF141259; 1.
DR SUPFAM; SSF143517; SSF143517; 1.
DR SUPFAM; SSF52540; SSF52540; 4.
DR TIGRFAMs; TIGR00580; mfd; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
DR PRODOM; D6XV49.
DR SWISS-2DPAGE; D6XV49.
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00969,
KW ECO:0000256|SAAS:SAAS01144540}; Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000000271};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969,
KW ECO:0000256|SAAS:SAAS01144521};
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00969,
KW ECO:0000256|SAAS:SAAS01144538};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00969,
KW ECO:0000256|SAAS:SAAS01144510};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00969};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00969,
KW ECO:0000256|SAAS:SAAS01144519};
KW Reference proteome {ECO:0000313|Proteomes:UP000000271}.
FT DOMAIN 638 799 Helicase ATP-binding.
FT {ECO:0000259|PROSITE:PS51192}.
FT DOMAIN 824 974 Helicase C-terminal.
FT {ECO:0000259|PROSITE:PS51194}.
FT COILED 237 260 {ECO:0000256|SAM:Coils}.
FT COILED 622 642 {ECO:0000256|SAM:Coils}.
SQ SEQUENCE 1186 AA; 134284 MW; DBB06E9BEFC67795 CRC64;
MEGLLNSLSA AGELEKVIKG IEDGAGDQSL VGISGSARAM HLAALFRRTG KSQLIVTHNL
FQAQKLYDDL ITVLNTDDVL LYPANELISS EIAVASPEMR GQRLEVMNEW STGAKRIVIA
PVAGVRRLLS PPDLWQEQRL TFTVGEDVDF DRTLGQFVNM GYSRADMVSA PGEFSVRGGI
IDVYPLTEEY PVRIELFDTE VDSIRLFDVE TQRSVDERST VVAGPAREII VQDVQYIRAA
ERLDEQLAKS LKRLKDDQIK ETMINNVGEE IESLKNRQFF DAIYKYMTLL YERPATLFDY
MPDDTLVVLD EWARVQETAA TLEREEAEWM TMMIAQGAMV HDLSVSATLE HLVSETERQK
LYIMLFGRQI PKVGPDRTYN VQTKTMQQFH GQIHLLKTEV ERWKEAGYAI VFVSGDDERA
EKLERVLADY EIEASPAKAG SEPVKGKALI VQGLLHNGFE LPLQRIVVIA EEDVFTRKSR
KPKRRQKLSN AERIKNYSEL KTGDWVVHIN HGIGKYLGIE TLQVGDVHKD YLHISYAGND
KLYVPVDQID QVQKYVANED KDPKLYSLGG SEWKKVKKKV QSSVQDIADD LIKLYAERQE
TKGFAFSPDG LEQREFESTF PYQETDDQLQ AIEEIKKDME QDRPMDRLLC GDVGYGKTEV
ALRAAFKAIM DGKQVAILVP TTILAQQHYE TIRERFQDFA INIGMLSRFR TRKQMKETTE
ALRKGTCDIV VGTHRILSKD VAFKELGLLV VDEEQRFGVT HKEKIKQLKA NVDVLTLTAT
PIPRTLHMSM LGVRDLSVIE TPPENRFPVQ TYVVEHNDAF VREAIERELA REGQVFYLYN
RVEDIEMVAD RIGMMVPDAN IAFAHGRMTE AQLEAVMLDF LSGETDVLVT TTIIETGVDI
PNVNTLIIQE ADRMGLSQLY QLRGRVGRSN RVAYAYFTHQ QDKVLTEVAE RRLQSIKEFT
ELGSGFKIAM RDLSIRGAGN LLGAEQHGFI ASVGFDLYSQ MLKEAIDDRK AGMDGKEEAE
AQPSQAPDID LDIQVDAYIP ESYIYDSKQK IDMYKRFKAI ESFDDVEDLQ VELIDRFGDF
PDEVVRLFSV AKIRLYAKQE GVTSIAEKNK ECKVVLEEEA AAKIDGAKLF SLVNKLSSHI
TLSSDGKGIT IHIKTKQIDD NLYLRLLEEV LARLDEVEKS RVTQGG
//
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