(data stored in ACNUC7421 zone)

SWISSPROT: D6XVU5_BACIE

ID   D6XVU5_BACIE            Unreviewed;       490 AA.
AC   D6XVU5;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 68.
DE   SubName: Full=Betaine aldehyde dehydrogenase {ECO:0000313|EMBL:ADH97718.1};
GN   OrderedLocusNames=Bsel_0170 {ECO:0000313|EMBL:ADH97718.1};
OS   Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Sporolactobacillaceae;
OC   unclassified Sporolactobacillaceae.
OX   NCBI_TaxID=439292 {ECO:0000313|EMBL:ADH97718.1, ECO:0000313|Proteomes:UP000000271};
RN   [1] {ECO:0000313|EMBL:ADH97718.1, ECO:0000313|Proteomes:UP000000271}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700615 / DSM 15326 / MLS10
RC   {ECO:0000313|Proteomes:UP000000271};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ovchinnikova G., Stolz J.;
RT   "Complete sequence of Bacillus selenitireducens MLS10.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=betaine aldehyde + H2O + NAD(+) = betaine + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:15305, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15710, ChEBI:CHEBI:17750,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.8;
CC         Evidence={ECO:0000256|SAAS:SAAS01117497};
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC       {ECO:0000256|SAAS:SAAS00007642}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345, ECO:0000256|SAAS:SAAS00559231}.
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DR   EMBL; CP001791; ADH97718.1; -; Genomic_DNA.
DR   RefSeq; WP_013171147.1; NC_014219.1.
DR   STRING; 439292.Bsel_0170; -.
DR   EnsemblBacteria; ADH97718; ADH97718; Bsel_0170.
DR   KEGG; bse:Bsel_0170; -.
DR   eggNOG; ENOG4105C26; Bacteria.
DR   eggNOG; COG1012; LUCA.
DR   HOGENOM; HOG000271505; -.
DR   KO; K00130; -.
DR   OMA; DTSWQCL; -.
DR   OrthoDB; 744602at2; -.
DR   BioCyc; BSEL439292:G1GLR-194-MONOMER; -.
DR   UniPathway; UPA00529; UER00386.
DR   Proteomes; UP000000271; Chromosome.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR011264; BADH.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6XVU5.
DR   SWISS-2DPAGE; D6XVU5.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000271};
KW   NAD {ECO:0000256|SAAS:SAAS00445496};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345,
KW   ECO:0000256|SAAS:SAAS00445500};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000271}.
FT   DOMAIN       13    478       Aldedh. {ECO:0000259|Pfam:PF00171}.
FT   COILED       72     92       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    251    251       {ECO:0000256|PROSITE-ProRule:PRU10007}.
FT   ACT_SITE    285    285       {ECO:0000256|PROSITE-ProRule:PRU10008}.
SQ   SEQUENCE   490 AA;  53234 MW;  C1194612C4236D5E CRC64;
     MNLTCKQYIN GEWVDAVSGE TRTIINPFNQ DVIATVPEGN RDDAKAAIAA ARQAFDDGAW
     AERPATERGA IVRTIAELIE RDREELAELE SLDTGKTVEE SRGDMDDIAG VFRYYAEMAD
     KSGGELIDSP VAESVSKVVY EPVGVCGQIT PWNYPLLQAS WKLAPALITG NTLVMKPSEI
     TPLTTVKVFA LMEEAGVPKG VANLVLGAGH TVGAELSESL DVDLISFTGG IVTGKKIMQA
     ASVNVKKLAL ELGGKNPNII FADADFDTAV DQALNGVFFH AGQICSAGTR LVVEESIHDA
     FVDALVKRVE NFKLGNGFDD DTQMGPLISK EHLEKVEAYV ENGVKEGANL VTGGKRPEDP
     ALKNGFFYLP TIFTGCKSEM DVVQDEAFGP VITVETFKTE EEAVTIANDS IYGLAGGVWT
     NDIVKAERCA KKMRMGTVWI NDFNLYFPHA PWGGFKQSGI GRELGKLGIE EYTESKHIFQ
     NLNPQPLNWF
//

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