(data stored in SCRATCH zone)

SWISSPROT: A0A0F6BI27_GEOS0

ID   A0A0F6BI27_GEOS0        Unreviewed;       485 AA.
AC   A0A0F6BI27;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   11-DEC-2019, entry version 27.
DE   SubName: Full=Integral membrane sensor signal transduction histidine kinase {ECO:0000313|EMBL:ADP73078.1};
GN   OrderedLocusNames=GY4MC1_0229 {ECO:0000313|EMBL:ADP73078.1};
OS   Geobacillus sp. (strain Y4.1MC1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   unclassified Geobacillus.
OX   NCBI_TaxID=581103 {ECO:0000313|EMBL:ADP73078.1};
RN   [1] {ECO:0000313|EMBL:ADP73078.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4.1MC1 {ECO:0000313|EMBL:ADP73078.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Brumm P.,
RA   Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP002293; ADP73078.1; -; Genomic_DNA.
DR   EnsemblBacteria; ADP73078; ADP73078; GY4MC1_0229.
DR   KEGG; gmc:GY4MC1_0229; -.
DR   OMA; PCMILQP; -.
DR   BioCyc; GSP581103:G1GOQ-272-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF06580; His_kinase; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; A0A0F6BI27.
DR   SWISS-2DPAGE; A0A0F6BI27.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00776324};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|SAAS:SAAS00529081, ECO:0000313|EMBL:ADP73078.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00833905, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00777800};
KW   Transferase {ECO:0000256|SAAS:SAAS00529055};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00833930, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00833995,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM        9..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          199..252
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          276..480
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   COILED          233..270
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   485 AA;  56024 MW;  6A85B9F4B3CB96FB CRC64;
     MIKIRTKALF YFGIFIVLLN GTVFFFYQSS EDIVTDYDYS MRRLLLFNEI SQRTNRMVEQ
     LNAYLTEKDG RYFREYERQY RWLQQHRRQV GETLSNRNNR LLVKNYEHMI ESLLEEGALT
     VYHFQAGNIS LYSSHLHEAM KIASFIQETT LSLIDEELTT YQHFYNEVEA RNRYFRYMGI
     GLSMTTFLLG VLLAVWFSGG LTRPIARLSR AAREIASGKL DGPDVISTTN DELKLLTDTF
     NDMRRNLKRL IEEMKQKSEL DRLVKELELK SLQSQMNPHF LFNTLNAVAK MAYLEEANQT
     SRLIEAIAAI LRYNLGDLQR TVTLADEVRI AHEYFFIQQT RFFDRIKFSM DVEESCLSLP
     IPPLTLQPLI ENAFIHGIES YEKGAVLSLT VEKRKNLVVI EIRDNGVGMS EEVKEKLTAF
     IKGEEAGSIS HGQTRGHSTG IGMYNVIRRL QLFYGMQDVI EIESAAGKGT TIRLLLPITK
     GGRGE
//

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