(data stored in SCRATCH zone)

SWISSPROT: A0A0F6BI49_GEOS0

ID   A0A0F6BI49_GEOS0        Unreviewed;       542 AA.
AC   A0A0F6BI49;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   11-DEC-2019, entry version 29.
DE   SubName: Full=Drug resistance transporter, EmrB/QacA subfamily {ECO:0000313|EMBL:ADP73100.1};
GN   OrderedLocusNames=GY4MC1_0252 {ECO:0000313|EMBL:ADP73100.1};
OS   Geobacillus sp. (strain Y4.1MC1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   unclassified Geobacillus.
OX   NCBI_TaxID=581103 {ECO:0000313|EMBL:ADP73100.1};
RN   [1] {ECO:0000313|EMBL:ADP73100.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4.1MC1 {ECO:0000313|EMBL:ADP73100.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Brumm P.,
RA   Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS01209748}.
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DR   EMBL; CP002293; ADP73100.1; -; Genomic_DNA.
DR   EnsemblBacteria; ADP73100; ADP73100; GY4MC1_0252.
DR   KEGG; gmc:GY4MC1_0252; -.
DR   OMA; GNKKGWL; -.
DR   BioCyc; GSP581103:G1GOQ-294-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   PANTHER; PTHR23501; PTHR23501; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0F6BI49.
DR   SWISS-2DPAGE; A0A0F6BI49.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00089479};
KW   Membrane {ECO:0000256|SAAS:SAAS00461656, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00461646, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00461653,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00089612}.
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        110..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        143..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        310..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        340..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        406..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        497..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          20..522
FT                   /note="MFS"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
SQ   SEQUENCE   542 AA;  59001 MW;  D009E4D9FB05B642 CRC64;
     MEKENELAMQ SSTIRHRNIL ITGLIIAMLF GALDGTIVGT AMPRIVGELG GLRLMTWLTT
     AYMLTSTAVV PIAGKLADLL GRRVIYVTGL VIFMVGSALC GMADKMTELV IYRGLQGIGG
     GIMMPMAMIV IGDVFTGKER AKWQGVFGAL YGLASVLGPQ IGGFIVDHLN WRWVFYINLP
     IGILATIFIA MGLSKYKAEG PVKFDLAGMF TMIVGVVSLL LALTFGGDKY EWASWQIVTL
     FAVALVFLTV FVFVEMKAEE PILPMHLFRH RTFIVLNGIG FLMSVGMFGA IMFVPFFMQG
     VIGVSATQSG TIMTPMMITM IIGSIVGGRT VYKIGVKSQI FIGMVIMAAG FSLLSTMGVD
     TSKWTATLYM IILGLGMGLV MPILTLALQE SFPKSELGVV TSSSQFFRSI GGTFGMTILG
     AVMNHRSSQL LDDRFMPVLQ SLPAQAKGMA DRFAHMIHDD PQGLYSILFS PEVLEKIPPQ
     MRETFVPILK QSLVDSLHSV FLFGLIFVIG GTALVFGMKK IKLSDKQRPL QTSGKNEKLP
     QS
//

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