(data stored in ACNUC7421 zone)

SWISSPROT: A0A0F6BIQ2_GEOS0

ID   A0A0F6BIQ2_GEOS0        Unreviewed;       504 AA.
AC   A0A0F6BIQ2;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   08-MAY-2019, entry version 24.
DE   SubName: Full=5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase {ECO:0000313|EMBL:ADP73303.1};
GN   OrderedLocusNames=GY4MC1_0470 {ECO:0000313|EMBL:ADP73303.1};
OS   Geobacillus sp. (strain Y4.1MC1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=581103 {ECO:0000313|EMBL:ADP73303.1, ECO:0000313|Proteomes:UP000002034};
RN   [1] {ECO:0000313|EMBL:ADP73303.1, ECO:0000313|Proteomes:UP000002034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4.1MC1 {ECO:0000313|EMBL:ADP73303.1,
RC   ECO:0000313|Proteomes:UP000002034};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N.,
RA   Ovchinnikova G., Brumm P., Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP002293; ADP73303.1; -; Genomic_DNA.
DR   RefSeq; WP_003248193.1; NC_014650.1.
DR   EnsemblBacteria; ADP73303; ADP73303; GY4MC1_0470.
DR   GeneID; 29236875; -.
DR   KEGG; gmc:GY4MC1_0470; -.
DR   KO; K00151; -.
DR   OMA; EGGHYSF; -.
DR   OrthoDB; 744602at2; -.
DR   BioCyc; GSP581103:G1GOQ-520-MONOMER; -.
DR   Proteomes; UP000002034; Chromosome.
DR   GO; GO:0018480; F:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity; IEA:InterPro.
DR   GO; GO:1901023; P:4-hydroxyphenylacetate catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR011985; DH_HpaE.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   TIGRFAMs; TIGR02299; HpaE; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0F6BIQ2.
DR   SWISS-2DPAGE; A0A0F6BIQ2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002034};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN       16    477       Aldedh. {ECO:0000259|Pfam:PF00171}.
FT   ACT_SITE    254    254       {ECO:0000256|PROSITE-ProRule:PRU10007}.
FT   ACT_SITE    288    288       {ECO:0000256|PROSITE-ProRule:PRU10008}.
SQ   SEQUENCE   504 AA;  55767 MW;  64406693C0E4B57C CRC64;
     MAGKIGNVLH YINGEFVEGA SGNYFENVNP FTNEIINEVA EGWKEDIDAA VRAAKEAFDN
     GPWRTMSVQE RMTYILRIAD LIEKYAEEIS YLESLDTGLP ISQTKKQAAR AAENFRFYAE
     MVKSRMVGEA YHVDGQFLNY TIYKPVGVAG LITPWNAPFM LETWKVAPAL ATGNTVVLKP
     AEWSPLTANK LAEIIHEAGL PQGVFNVVHG FGETAGASLV AHPNVRLISF TGETTTGSEI
     IKNSADTLKK TSMELGGKSP VIVFADADVE KALDAVVWGI FSFNGERCTA NSRLFLEKSI
     YDSFVEKLKE RVNNISIGDP MDPATEVGPL IHRKHWETVM NYIEIAKQEG AEVYSADVPE
     ELKKGNFVPP TLLLNCHNSM KVAQEEIFGP VMAVMPFETE EEVIRMANDV KYGLAAYVWT
     NDIKRGHRVA QSIESGMAWV NSQNVRDLRI PFGGTKYSGI GREGGHYSFD FYTEVQVIHV
     SIGDHSIPKF GKIKQHSAAS AQRG
//

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