(data stored in ACNUC7421 zone)

SWISSPROT: A0A0F6BIS2_GEOS0

ID   A0A0F6BIS2_GEOS0        Unreviewed;       305 AA.
AC   A0A0F6BIS2;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   08-MAY-2019, entry version 23.
DE   SubName: Full=Proline dehydrogenase {ECO:0000313|EMBL:ADP73323.1};
DE            EC=1.5.5.2 {ECO:0000313|EMBL:ADP73323.1};
GN   OrderedLocusNames=GY4MC1_0490 {ECO:0000313|EMBL:ADP73323.1};
OS   Geobacillus sp. (strain Y4.1MC1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=581103 {ECO:0000313|EMBL:ADP73323.1, ECO:0000313|Proteomes:UP000002034};
RN   [1] {ECO:0000313|EMBL:ADP73323.1, ECO:0000313|Proteomes:UP000002034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4.1MC1 {ECO:0000313|EMBL:ADP73323.1,
RC   ECO:0000313|Proteomes:UP000002034};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N.,
RA   Ovchinnikova G., Brumm P., Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000196-2};
CC       Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR000196-2};
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DR   EMBL; CP002293; ADP73323.1; -; Genomic_DNA.
DR   RefSeq; WP_013400059.1; NC_014650.1.
DR   EnsemblBacteria; ADP73323; ADP73323; GY4MC1_0490.
DR   GeneID; 29236856; -.
DR   KEGG; gmc:GY4MC1_0490; -.
DR   KO; K00318; -.
DR   OMA; PYGRDWY; -.
DR   OrthoDB; 1746057at2; -.
DR   BioCyc; GSP581103:G1GOQ-540-MONOMER; -.
DR   Proteomes; UP000002034; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0010133; P:proline catabolic process to glutamate; IEA:InterPro.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR008219; PRODH_bac_arc.
DR   InterPro; IPR002872; Proline_DH_dom.
DR   InterPro; IPR015659; Proline_oxidase.
DR   PANTHER; PTHR13914; PTHR13914; 2.
DR   Pfam; PF01619; Pro_dh; 1.
DR   PIRSF; PIRSF000196; Pro_dehydrog; 1.
DR   SUPFAM; SSF51730; SSF51730; 1.
PE   4: Predicted;
DR   PRODOM; A0A0F6BIS2.
DR   SWISS-2DPAGE; A0A0F6BIS2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002034};
KW   FAD {ECO:0000256|PIRSR:PIRSR000196-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR000196-2};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000196-2};
KW   Oxidoreductase {ECO:0000313|EMBL:ADP73323.1}.
FT   DOMAIN       44    298       Pro_dh. {ECO:0000259|Pfam:PF01619}.
FT   NP_BIND     185    187       FAD. {ECO:0000256|PIRSR:PIRSR000196-2}.
FT   NP_BIND     224    225       FAD. {ECO:0000256|PIRSR:PIRSR000196-2}.
FT   BINDING      98     98       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000196-1}.
FT   BINDING     133    133       FAD. {ECO:0000256|PIRSR:PIRSR000196-2}.
FT   BINDING     161    161       FAD. {ECO:0000256|PIRSR:PIRSR000196-2}.
FT   BINDING     199    199       FAD. {ECO:0000256|PIRSR:PIRSR000196-2}.
FT   BINDING     286    286       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000196-1}.
FT   BINDING     287    287       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000196-1}.
SQ   SEQUENCE   305 AA;  35641 MW;  9EACCCA106B08B6B CRC64;
     MEQVMRNFFL FLSKNKPLTR LAKKYGLRFG ASRFVAGETI EQAVEVIKQL NKKGLAVTVD
     YLGEFVDNEQ EANDMADHCI EAIEAIHREK LDAQLSLKMT SMGLDISEEL VMRNMRRILD
     TAKLHDVFVT IDMEDYSRCQ KTLDIFKRLK TEYDNVGTVL QAYLYRTVSD IEDLKNYHPN
     LRLVKGAYKE PPEVAFPDKK DVDENFKKII KMHLLNGNYT AVATHDDAII EYTKRLVKEY
     NIPNSQFEFQ MLYGIRPERQ EQLAREGYTM RVYVPYGTDW YGYFMRRLAE RPANVAFVLK
     GVLRK
//

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