(data stored in ACNUC7421 zone)

SWISSPROT: A0A0F6BIS5_GEOS0

ID   A0A0F6BIS5_GEOS0        Unreviewed;       794 AA.
AC   A0A0F6BIS5;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   08-MAY-2019, entry version 26.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase NAD-binding protein {ECO:0000313|EMBL:ADP73326.1};
GN   OrderedLocusNames=GY4MC1_0494 {ECO:0000313|EMBL:ADP73326.1};
OS   Geobacillus sp. (strain Y4.1MC1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=581103 {ECO:0000313|EMBL:ADP73326.1, ECO:0000313|Proteomes:UP000002034};
RN   [1] {ECO:0000313|EMBL:ADP73326.1, ECO:0000313|Proteomes:UP000002034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4.1MC1 {ECO:0000313|EMBL:ADP73326.1,
RC   ECO:0000313|Proteomes:UP000002034};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N.,
RA   Ovchinnikova G., Brumm P., Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; CP002293; ADP73326.1; -; Genomic_DNA.
DR   RefSeq; WP_013400062.1; NC_014650.1.
DR   EnsemblBacteria; ADP73326; ADP73326; GY4MC1_0494.
DR   KEGG; gmc:GY4MC1_0494; -.
DR   KO; K07516; -.
DR   OMA; GQGFYKK; -.
DR   OrthoDB; 82358at2; -.
DR   BioCyc; GSP581103:G1GOQ-545-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000002034; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
DR   PRODOM; A0A0F6BIS5.
DR   SWISS-2DPAGE; A0A0F6BIS5.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002034};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN        7    205       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      208    305       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      362    412       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   COILED       52     72       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   794 AA;  88054 MW;  25C412856BAE3AA9 CRC64;
     MVKRIQKAAV LGSGVMGSGI AAHLANVGIP TLLLDIVPRE LTKEEEAKGL TLEHKEVRNR
     LANQALQKLL KQKPAPFMSK SNLALIETGN FADDFHRLAE VDWIIEAVVE NLEIKKSVFA
     MVDEVRKPGT IVSSNTSGIS IETMAEGCSE DFKKHFLGTH FFNPPRYLKL LEIIPTKDTD
     PEVVSYMKTF GEEVLGKGVV MAKDTPNFIA NRIGTYGLLV TVREMMKGGY SVGEVDSLTG
     PLIGRPKSAT FRTLDVVGLD TFIHVANNVF EKVEGEEKEA FRVPDFMKAM LEKGWIGSKS
     GQGFFWKQGK DILELNYETL EYEPRKKLTT PAVEASKQAK KLNDKLKALV YADDRAGTFL
     WKIIAPVLLY SAKLLGEIAD DIVAIDRAMK WGFGWELGPF EMWDALGVEQ SVRKMQAEGL
     DIPSWVTDML AAGFPFFYKS EKGQVFYYDR GEYKQIHENP KVIHIKRLKE QRDVIKKNSG
     ASLIDLGDDV ALLEFHSPNN AIGTDIVQMI NYALEEVERN YKGLVIGNQG KNFCVGANLA
     MILMEAQDDN YFEIELAVRQ FQQAMMNIKY STKPVVAAPF AMTLGGGVEV CLPSSRIQAA
     AETYMGLVEV GVGLIPGGGG NKELYIKYLN SLPSGVHFDL QQVANKVFET IALAKVSGSA
     AEARELNFLN QRDGITMNSD HLIHDAKQAV ISLYDQGYRP PVRKKVPVVG ETGYAAMLLG
     AQSMYHSGYI SEHDLKIAKK LAYVIAGGKV PYGTEVDEQY LLDLEREAFL SLVGEPKSQA
     RMQHMLVKGK PLRN
//

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