(data stored in ACNUC7421 zone)

SWISSPROT: E3J4V9_FRAIE

ID   E3J4V9_FRAIE            Unreviewed;       303 AA.
AC   E3J4V9;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   08-MAY-2019, entry version 54.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00667901};
DE            EC=6.3.2.6 {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00337892};
DE   AltName: Full=SAICAR synthetase {ECO:0000256|HAMAP-Rule:MF_00137};
GN   Name=purC {ECO:0000256|HAMAP-Rule:MF_00137};
GN   OrderedLocusNames=FraEuI1c_0190 {ECO:0000313|EMBL:ADP78278.1};
OS   Frankia inefficax (strain DSM 45817 / CECT 9037 / EuI1c).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298654 {ECO:0000313|EMBL:ADP78278.1, ECO:0000313|Proteomes:UP000002484};
RN   [1] {ECO:0000313|EMBL:ADP78278.1, ECO:0000313|Proteomes:UP000002484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45817 / CECT 9037 / EuI1c
RC   {ECO:0000313|Proteomes:UP000002484};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Beauchemin N., Sen A., Sur S.A., Gtari M., Wall L., Tisa L., Woyke T.;
RT   "Complete sequence of Frankia sp. EuI1c.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate +
CC         ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-
CC         ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) +
CC         phosphate; Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58443, ChEBI:CHEBI:77657, ChEBI:CHEBI:456216;
CC         EC=6.3.2.6; Evidence={ECO:0000256|HAMAP-Rule:MF_00137,
CC         ECO:0000256|SAAS:SAAS01117176};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC       {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00194440}.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00535425}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP002299; ADP78278.1; -; Genomic_DNA.
DR   RefSeq; WP_013421401.1; NC_014666.1.
DR   STRING; 298654.FraEuI1c_0190; -.
DR   EnsemblBacteria; ADP78278; ADP78278; FraEuI1c_0190.
DR   KEGG; fri:FraEuI1c_0190; -.
DR   eggNOG; ENOG4105C8V; Bacteria.
DR   eggNOG; COG0152; LUCA.
DR   HOGENOM; HOG000230360; -.
DR   KO; K01923; -.
DR   OMA; EMVIRGY; -.
DR   OrthoDB; 1345271at2; -.
DR   BioCyc; FSP298654:G1GOT-193-MONOMER; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000002484; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR001636; SAICAR_synth.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; E3J4V9.
DR   SWISS-2DPAGE; E3J4V9.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00194460};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002484};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00194461, ECO:0000313|EMBL:ADP78278.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00194457};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00194459};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002484}.
FT   DOMAIN       14    268       SAICAR_synt. {ECO:0000259|Pfam:PF01259}.
SQ   SEQUENCE   303 AA;  33044 MW;  D0434836876096F7 CRC64;
     MPLTHVEFAG LTHLGSGKVR ELFAVGDDAV LLVASDRISA FDVILPTEIP DKGAVLTGLS
     LWWFDQLADL VPSHVISSNV DEYPDELQPY AEQLRGRSML CHRLDMALVE CVARGYLTGS
     GLKDYVRTGA VSGHTLPEGL VDGSKLPHPI YTPSTKAPIG EHDENISRAD AATRIGDDLA
     AELEKLTLQI FGRASDLAAE RGILLADTKF EFGHDPAGVL RLGDEVLTPD SSRFWPADSW
     APGGAQPSYD KQFIRDYLVN TGWDKVSPAP ELPDDIVFST RSRYVEAYER LTGISFADYL
     ATS
//

If you have problems or comments...

PBIL Back to PBIL home page