(data stored in ACNUC7421 zone)

SWISSPROT: E3J7B8_FRAIE

ID   E3J7B8_FRAIE            Unreviewed;       234 AA.
AC   E3J7B8;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   RecName: Full=GTP cyclohydrolase 1 {ECO:0000256|HAMAP-Rule:MF_00223};
DE            EC=3.5.4.16 {ECO:0000256|HAMAP-Rule:MF_00223};
DE   AltName: Full=GTP cyclohydrolase I {ECO:0000256|HAMAP-Rule:MF_00223};
DE            Short=GTP-CH-I {ECO:0000256|HAMAP-Rule:MF_00223};
GN   Name=folE {ECO:0000256|HAMAP-Rule:MF_00223};
GN   OrderedLocusNames=FraEuI1c_0305 {ECO:0000313|EMBL:ADP78391.1};
OS   Frankia inefficax (strain DSM 45817 / CECT 9037 / EuI1c).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298654 {ECO:0000313|EMBL:ADP78391.1, ECO:0000313|Proteomes:UP000002484};
RN   [1] {ECO:0000313|EMBL:ADP78391.1, ECO:0000313|Proteomes:UP000002484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45817 / CECT 9037 / EuI1c
RC   {ECO:0000313|Proteomes:UP000002484};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Beauchemin N., Sen A., Sur S.A., Gtari M., Wall L., Tisa L., Woyke T.;
RT   "Complete sequence of Frankia sp. EuI1c.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate +
CC         formate + H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:58462; EC=3.5.4.16; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00223, ECO:0000256|SAAS:SAAS01118752};
CC   -!- PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate
CC       biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step
CC       1/1. {ECO:0000256|HAMAP-Rule:MF_00223,
CC       ECO:0000256|SAAS:SAAS00021202}.
CC   -!- SUBUNIT: Homopolymer. {ECO:0000256|HAMAP-Rule:MF_00223}.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase I family.
CC       {ECO:0000256|HAMAP-Rule:MF_00223, ECO:0000256|SAAS:SAAS00673743}.
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DR   EMBL; CP002299; ADP78391.1; -; Genomic_DNA.
DR   RefSeq; WP_013421514.1; NC_014666.1.
DR   STRING; 298654.FraEuI1c_0305; -.
DR   EnsemblBacteria; ADP78391; ADP78391; FraEuI1c_0305.
DR   KEGG; fri:FraEuI1c_0305; -.
DR   eggNOG; ENOG4105EUJ; Bacteria.
DR   eggNOG; COG0302; LUCA.
DR   HOGENOM; HOG000221222; -.
DR   KO; K01495; -.
DR   OMA; IVVVECE; -.
DR   OrthoDB; 1632367at2; -.
DR   BioCyc; FSP298654:G1GOT-305-MONOMER; -.
DR   UniPathway; UPA00848; UER00151.
DR   Proteomes; UP000002484; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00223; FolE; 1.
DR   InterPro; IPR001474; GTP_CycHdrlase_I.
DR   InterPro; IPR018234; GTP_CycHdrlase_I_CS.
DR   InterPro; IPR020602; GTP_CycHdrlase_I_dom.
DR   PANTHER; PTHR11109; PTHR11109; 1.
DR   Pfam; PF01227; GTP_cyclohydroI; 1.
DR   TIGRFAMs; TIGR00063; folE; 1.
DR   PROSITE; PS00859; GTP_CYCLOHYDROL_1_1; 1.
DR   PROSITE; PS00860; GTP_CYCLOHYDROL_1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; E3J7B8.
DR   SWISS-2DPAGE; E3J7B8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002484};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_00223};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00223,
KW   ECO:0000256|SAAS:SAAS00021177, ECO:0000313|EMBL:ADP78391.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00223,
KW   ECO:0000256|SAAS:SAAS00021169};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00223};
KW   One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00223,
KW   ECO:0000256|SAAS:SAAS00021243};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002484};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00223, ECO:0000256|SAAS:SAAS00021207}.
FT   DOMAIN       52    228       GTP_cyclohydroI. {ECO:0000259|Pfam:
FT                                PF01227}.
FT   METAL       120    120       Zinc. {ECO:0000256|HAMAP-Rule:MF_00223}.
FT   METAL       123    123       Zinc. {ECO:0000256|HAMAP-Rule:MF_00223}.
FT   METAL       193    193       Zinc. {ECO:0000256|HAMAP-Rule:MF_00223}.
SQ   SEQUENCE   234 AA;  25294 MW;  E0FD6A96C60A3576 CRC64;
     MTSETDLLSA DLDHLDDEGG SAAETGSGSG AAVAEFRPGN GRIRPFDHDR VAAAVRELLI
     GIGEDPDREG LRKTPDRVAR AYAEAVEGLG RDPADVLTTV FDEGHDEMVL VRDIDFSSLC
     EHHLVVFSGK AHVAYIPNEN GQITGLSKLA RLVDLYARRP QVQERLTSQV ADALVDVLQP
     RGVMVVVEAE HLCMSMRGVR KPGACTVTSA VRGQFLSPAT RNEGMSLILS SHRR
//

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