(data stored in ACNUC7421 zone)

SWISSPROT: E3J9Z8_FRAIE

ID   E3J9Z8_FRAIE            Unreviewed;       532 AA.
AC   E3J9Z8;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   RecName: Full=Cobyric acid synthase {ECO:0000256|HAMAP-Rule:MF_00028};
GN   Name=cobQ {ECO:0000256|HAMAP-Rule:MF_00028};
GN   OrderedLocusNames=FraEuI1c_0477 {ECO:0000313|EMBL:ADP78560.1};
OS   Frankia inefficax (strain DSM 45817 / CECT 9037 / EuI1c).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298654 {ECO:0000313|EMBL:ADP78560.1, ECO:0000313|Proteomes:UP000002484};
RN   [1] {ECO:0000313|EMBL:ADP78560.1, ECO:0000313|Proteomes:UP000002484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45817 / CECT 9037 / EuI1c
RC   {ECO:0000313|Proteomes:UP000002484};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Beauchemin N., Sen A., Sur S.A., Gtari M., Wall L., Tisa L., Woyke T.;
RT   "Complete sequence of Frankia sp. EuI1c.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes amidations at positions B, D, E, and G on
CC       adenosylcobyrinic A,C-diamide. NH(2) groups are provided by
CC       glutamine, and one molecule of ATP is hydrogenolyzed for each
CC       amidation. {ECO:0000256|HAMAP-Rule:MF_00028,
CC       ECO:0000256|SAAS:SAAS00709802}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00028, ECO:0000256|SAAS:SAAS00709784}.
CC   -!- SIMILARITY: Belongs to the CobB/CobQ family. CobQ subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00028, ECO:0000256|SAAS:SAAS00709810}.
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DR   EMBL; CP002299; ADP78560.1; -; Genomic_DNA.
DR   RefSeq; WP_013421682.1; NC_014666.1.
DR   STRING; 298654.FraEuI1c_0477; -.
DR   EnsemblBacteria; ADP78560; ADP78560; FraEuI1c_0477.
DR   KEGG; fri:FraEuI1c_0477; -.
DR   eggNOG; ENOG4105CAA; Bacteria.
DR   eggNOG; COG1492; LUCA.
DR   HOGENOM; HOG000224803; -.
DR   KO; K02232; -.
DR   OMA; QVIIHGR; -.
DR   OrthoDB; 744477at2; -.
DR   BioCyc; FSP298654:G1GOT-475-MONOMER; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000002484; Chromosome.
DR   GO; GO:0015420; F:cobalamin-transporting ATPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01750; GATase1_CobQ; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   HAMAP; MF_00028; CobQ; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR017929; CobB/CobQ_GATase.
DR   InterPro; IPR002586; CobQ/CobB/MinD/ParA_Nub-bd_dom.
DR   InterPro; IPR033949; CobQ_GATase1.
DR   InterPro; IPR004459; CobQ_synth.
DR   InterPro; IPR011698; GATase_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21343:SF1; PTHR21343:SF1; 1.
DR   Pfam; PF01656; CbiA; 1.
DR   Pfam; PF07685; GATase_3; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00313; cobQ; 1.
DR   PROSITE; PS51274; GATASE_COBBQ; 1.
PE   3: Inferred from homology;
DR   PRODOM; E3J9Z8.
DR   SWISS-2DPAGE; E3J9Z8.
KW   Cobalamin biosynthesis {ECO:0000256|HAMAP-Rule:MF_00028,
KW   ECO:0000256|PROSITE-ProRule:PRU00606, ECO:0000256|SAAS:SAAS00709774};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002484};
KW   Glutamine amidotransferase {ECO:0000256|HAMAP-Rule:MF_00028,
KW   ECO:0000256|PROSITE-ProRule:PRU00606, ECO:0000256|SAAS:SAAS00056751};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002484}.
FT   DOMAIN      253    426       GATase cobBQ-type. {ECO:0000259|PROSITE:
FT                                PS51274}.
FT   ACT_SITE    334    334       Nucleophile. {ECO:0000256|HAMAP-Rule:
FT                                MF_00028}.
FT   ACT_SITE    418    418       {ECO:0000256|HAMAP-Rule:MF_00028}.
SQ   SEQUENCE   532 AA;  55039 MW;  70AD24E763DC344C CRC64;
     MSGALLVAGT TSDAGKSVLT AGICRWLARQ GVRVAPFKAQ NMSLNSWVTA DGAEIGRAQV
     MQAAAAGVEP EGAMNPVLLK PGAGHRSQVV LRGRPVAEAG ALDYRALKGR LFTEVLASLA
     DLRSRFDVVI CEGAGSPAEI NLRADDIANM GLARAARLPT LVVGDIDRGG VFAAMFGTLA
     LLEPADQALV AGFVVNKFRG ERALLEPGLG MLSGLTGRPV LGVLPWRDGL GLDVEDSLGL
     PGPGETRGDL DGTLRVAAVR LPFLSNFTDL DALAAEPGVA VRYVDRPEDL DAADLVVLPG
     TRSTVADLAW LRGRRLDGPL ARRAATGRPV LGVCGGYQML AETIVDEVES GAGRVDGLGL
     LPVTIRFAAA KTLGRPDGVA YGQPVRGYEI HHGVASVHGG EPFLDGCRAG AVWGTTWHGA
     FENDGFRRAF LADVAARVGS PWQPRGEVSF AAVRERRLDV LGDLVAEHLD TDALLRLLAD
     GPPAGLPFIP PGAPTGAAGP ALAGGAPAPP VTAGLPEAGH LRSSVPDLGS RP
//

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