(data stored in ACNUC7421 zone)

SWISSPROT: E3JB95_FRAIE

ID   E3JB95_FRAIE            Unreviewed;       194 AA.
AC   E3JB95;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   RecName: Full=Cyclic pyranopterin monophosphate synthase {ECO:0000256|HAMAP-Rule:MF_01224};
DE            EC=4.6.1.17 {ECO:0000256|HAMAP-Rule:MF_01224};
DE   AltName: Full=Molybdenum cofactor biosynthesis protein C {ECO:0000256|HAMAP-Rule:MF_01224};
GN   Name=moaC {ECO:0000256|HAMAP-Rule:MF_01224};
GN   OrderedLocusNames=FraEuI1c_0543 {ECO:0000313|EMBL:ADP78625.1};
OS   Frankia inefficax (strain DSM 45817 / CECT 9037 / EuI1c).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298654 {ECO:0000313|EMBL:ADP78625.1, ECO:0000313|Proteomes:UP000002484};
RN   [1] {ECO:0000313|EMBL:ADP78625.1, ECO:0000313|Proteomes:UP000002484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45817 / CECT 9037 / EuI1c
RC   {ECO:0000313|Proteomes:UP000002484};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Beauchemin N., Sen A., Sur S.A., Gtari M., Wall L., Tisa L., Woyke T.;
RT   "Complete sequence of Frankia sp. EuI1c.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-
CC       dihydroguanosine 5'-triphosphate to cyclic pyranopterin
CC       monophosphate (cPMP). {ECO:0000256|HAMAP-Rule:MF_01224}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate =
CC         cyclic pyranopterin phosphate + diphosphate;
CC         Xref=Rhea:RHEA:49580, ChEBI:CHEBI:33019, ChEBI:CHEBI:59648,
CC         ChEBI:CHEBI:131766; EC=4.6.1.17; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01224, ECO:0000256|SAAS:SAAS01115723};
CC   -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_01224, ECO:0000256|SAAS:SAAS00100831}.
CC   -!- SUBUNIT: Homohexamer; trimer of dimers. {ECO:0000256|HAMAP-
CC       Rule:MF_01224}.
CC   -!- SIMILARITY: Belongs to the MoaC family. {ECO:0000256|HAMAP-
CC       Rule:MF_01224}.
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DR   EMBL; CP002299; ADP78625.1; -; Genomic_DNA.
DR   RefSeq; WP_013421747.1; NC_014666.1.
DR   STRING; 298654.FraEuI1c_0543; -.
DR   EnsemblBacteria; ADP78625; ADP78625; FraEuI1c_0543.
DR   KEGG; fri:FraEuI1c_0543; -.
DR   eggNOG; ENOG4108YXW; Bacteria.
DR   eggNOG; COG0315; LUCA.
DR   HOGENOM; HOG000228417; -.
DR   KO; K03637; -.
DR   OMA; IWDMVKS; -.
DR   OrthoDB; 1595361at2; -.
DR   BioCyc; FSP298654:G1GOT-546-MONOMER; -.
DR   UniPathway; UPA00344; -.
DR   Proteomes; UP000002484; Chromosome.
DR   GO; GO:0061799; F:cyclic pyranopterin monophosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01420; MoaC_PE; 1.
DR   Gene3D; 3.30.70.640; -; 1.
DR   HAMAP; MF_01224_B; MoaC_B; 1.
DR   InterPro; IPR023045; Mo_CF_biosynth-C.
DR   InterPro; IPR036522; MoaC_sf.
DR   InterPro; IPR002820; Mopterin_CF_biosynth-C_dom.
DR   Pfam; PF01967; MoaC; 1.
DR   SUPFAM; SSF55040; SSF55040; 1.
DR   TIGRFAMs; TIGR00581; moaC; 1.
PE   3: Inferred from homology;
DR   PRODOM; E3JB95.
DR   SWISS-2DPAGE; E3JB95.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002484};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_01224,
KW   ECO:0000256|SAAS:SAAS00703322};
KW   Molybdenum cofactor biosynthesis {ECO:0000256|HAMAP-Rule:MF_01224,
KW   ECO:0000256|SAAS:SAAS00100825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002484}.
FT   DOMAIN       18    151       MoaC. {ECO:0000259|Pfam:PF01967}.
FT   REGION       78     80       Substrate binding. {ECO:0000256|HAMAP-
FT                                Rule:MF_01224}.
FT   REGION      114    115       Substrate binding. {ECO:0000256|HAMAP-
FT                                Rule:MF_01224}.
FT   ACT_SITE    129    129       {ECO:0000256|HAMAP-Rule:MF_01224}.
SQ   SEQUENCE   194 AA;  19575 MW;  2C7C414FE2705531 CRC64;
     MDAPARLTHV DETGAARMVD VSAKDVTQRV ATAGGRLLVS PAVVELLRGA GMPKGDALGT
     ARIAGIMGAK RTSDLVPLCH PLPISGVSVE LTVADDAVDI VATVRTTGRT GVEMEALTAV
     AVAGLTMHDM VKAVDPAAEL TGVRLLAKSG GRSGDWRRDE AAGHGGPAAD RGPAGENGAA
     PANGRSGDLR EETG
//

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