(data stored in ACNUC1104 zone)

SWISSPROT: E6UXR9_VARPE

ID   E6UXR9_VARPE            Unreviewed;       459 AA.
AC   E6UXR9;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   SubName: Full=Integral membrane sensor signal transduction histidine kinase {ECO:0000313|EMBL:ADU34263.1};
GN   OrderedLocusNames=Varpa_0040 {ECO:0000313|EMBL:ADU34263.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34263.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34263.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34263.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP002417; ADU34263.1; -; Genomic_DNA.
DR   RefSeq; WP_013538510.1; NC_014931.1.
DR   STRING; 595537.Varpa_0040; -.
DR   EnsemblBacteria; ADU34263; ADU34263; Varpa_0040.
DR   GeneID; 29715382; -.
DR   KEGG; vpe:Varpa_0040; -.
DR   eggNOG; ENOG4105DAU; Bacteria.
DR   eggNOG; COG0642; LUCA.
DR   HOGENOM; HOG000223178; -.
DR   KO; K07649; -.
DR   OMA; YGGRTIT; -.
DR   OrthoDB; 692375at2; -.
DR   BioCyc; VPAR595537:G1GQO-40-MONOMER; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR013727; 2CSK_N.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF08521; 2CSK_N; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; E6UXR9.
DR   SWISS-2DPAGE; E6UXR9.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:ADU34263.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     21     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      190    242       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      250    459       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   459 AA;  49999 MW;  6BF650264737E347 CRC64;
     MTDSTAAPIA PSLTRRVLRN VLVPLALTWM LGAVIALVIA NYFSERAFDR GMLDDAYALS
     ANVQAGERGI ELLLTPREVA TVLFDQVDKI YFSVQRLDGT LISGESDLQA PLPVNGARYR
     FSDVTYQGKA MRAVTLDHDA EPGIAMPYRV VIAQTTLSRT ALVRQLLGFA LAPQILLLVL
     LAVWLWYGIR SDLRPLGDLQ RALDRRDVRD LSPVVVAQTS RELQRLGNAV NSLFERLGHS
     VQAQREFVGN VAHELRTPLA GIRALAEYGL AQHDTTVWRE QLERVSERQA RASHLIDQLL
     ALALAEEART SLARAPVRLD VLAEQTVLRH LARADARGVD LGARGLDDGV VVMANEALVE
     GILDNLIDNA LRYGGRTITV ELAGRTLSVI DDGPGIPLEA QRDLMQRWAQ GPAGEKLGQG
     SGLGLSIVSR YAELLGAELR LEAAEPVGLR VSVAFGEVA
//

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