(data stored in ACNUC1104 zone)

SWISSPROT: E6V0A2_VARPE

ID   E6V0A2_VARPE            Unreviewed;       349 AA.
AC   E6V0A2;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 50.
DE   SubName: Full=Homocysteine S-methyltransferase {ECO:0000313|EMBL:ADU34416.1};
GN   OrderedLocusNames=Varpa_0194 {ECO:0000313|EMBL:ADU34416.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34416.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34416.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34416.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037505-2};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR037505-
CC       2};
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DR   EMBL; CP002417; ADU34416.1; -; Genomic_DNA.
DR   RefSeq; WP_013538663.1; NC_014931.1.
DR   STRING; 595537.Varpa_0194; -.
DR   EnsemblBacteria; ADU34416; ADU34416; Varpa_0194.
DR   GeneID; 29719356; -.
DR   KEGG; vpe:Varpa_0194; -.
DR   eggNOG; ENOG4105C3R; Bacteria.
DR   eggNOG; COG0646; LUCA.
DR   HOGENOM; HOG000265279; -.
DR   KO; K00548; -.
DR   OMA; AQEDYKM; -.
DR   OrthoDB; 1149455at2; -.
DR   BioCyc; VPAR595537:G1GQO-195-MONOMER; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0047150; F:betaine-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.330; -; 1.
DR   InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT.
DR   InterPro; IPR003726; HCY_dom.
DR   InterPro; IPR036589; HCY_dom_sf.
DR   Pfam; PF02574; S-methyl_trans; 1.
DR   PIRSF; PIRSF037505; Betaine_HMT; 2.
DR   SUPFAM; SSF82282; SSF82282; 1.
DR   PROSITE; PS50970; HCY; 1.
PE   4: Predicted;
DR   PRODOM; E6V0A2.
DR   SWISS-2DPAGE; E6V0A2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037505-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00333};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00333,
KW   ECO:0000313|EMBL:ADU34416.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00333,
KW   ECO:0000313|EMBL:ADU34416.1};
KW   Zinc {ECO:0000256|PIRSR:PIRSR037505-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}.
FT   DOMAIN        9    330       Hcy-binding. {ECO:0000259|PROSITE:
FT                                PS50970}.
FT   METAL       249    249       Zinc. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00333}.
FT   METAL       315    315       Zinc. {ECO:0000256|PIRSR:PIRSR037505-2,
FT                                ECO:0000256|PROSITE-ProRule:PRU00333}.
FT   METAL       316    316       Zinc. {ECO:0000256|PIRSR:PIRSR037505-2,
FT                                ECO:0000256|PROSITE-ProRule:PRU00333}.
SQ   SEQUENCE   349 AA;  37587 MW;  D9C5B09304A7A408 CRC64;
     MKPLVYTRGQ ALAGILEKRI AILDGAMGTM IQRFKLTEEQ YRGERFKDFE RDVKGNNELL
     SLTRPDVISD IHEGYLAAGA DLIETNTFGA TTIAQEDYKM AHLAREMNLE SARIARAACD
     KFSTPDKPRF VAGALGPTPK TASISPDVND PGARNVDFEQ LRAAYYEQTE ALVEGGADVI
     LVETIFDTLN AKAALFAVDE YFDNSGERLP LIISGTVTDA SGRILSGQTV TAFWHSVRHA
     RPLAIGLNCA LGAALMRPYI QELARVAGDT FISCYPNAGL PNPMSDTGFD ETPDVTSRLL
     HEFAAEGLVN IVGGCCGTTP DHIAAIGRAV APVPGRLLNN TAGFYSEAA
//

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