(data stored in ACNUC1104 zone)

SWISSPROT: E6V1C2_VARPE

ID   E6V1C2_VARPE            Unreviewed;       399 AA.
AC   E6V1C2;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 56.
DE   SubName: Full=Integral membrane sensor signal transduction histidine kinase {ECO:0000313|EMBL:ADU34486.1};
GN   OrderedLocusNames=Varpa_0264 {ECO:0000313|EMBL:ADU34486.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34486.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34486.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34486.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP002417; ADU34486.1; -; Genomic_DNA.
DR   RefSeq; WP_013538732.1; NC_014931.1.
DR   STRING; 595537.Varpa_0264; -.
DR   EnsemblBacteria; ADU34486; ADU34486; Varpa_0264.
DR   GeneID; 29717636; -.
DR   KEGG; vpe:Varpa_0264; -.
DR   eggNOG; ENOG4105JJR; Bacteria.
DR   eggNOG; ENOG4111IA6; LUCA.
DR   HOGENOM; HOG000269852; -.
DR   OMA; DEYTFIQ; -.
DR   OrthoDB; 1827824at2; -.
DR   BioCyc; VPAR595537:G1GQO-266-MONOMER; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; E6V1C2.
DR   SWISS-2DPAGE; E6V1C2.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:ADU34486.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     12     33       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    111    130       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      131    183       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      191    396       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   399 AA;  43123 MW;  4B3CE9A20CC9BDDF CRC64;
     MLRKLYSGHL YVRIWLAVVG GVVILTLMAN WIVREAAEAE RERLAPVPRH VVVLDAQDRT
     IGSGTALRVP GQGLEFDVTL SDGKAITLRV APRERATGTG GFAPWRTPFG LGWMIALVGV
     AVALGVYPIV RRITQRLETL QRGVQRWGDG DLSVRVTEEG QDEVADLSKR FNASAERIEQ
     LVRSHKSLLA NASHELRSPL TRIRMGLELM GEHPSPKARE EISRNIGELD QLIDEILLAS
     RLDASEADMG TIEAVDLTGL AAEECSQVNA ELDLAEGTDN AALTVPGVSR LLRRAIRNLL
     ENARRYGAGS ISVELGSANG FATVRVNDRG PGVPPALRER IFEPFYRLPG ASERNGGVGL
     GLALVKSIAE RHGGTVRCED APEGGASFVI RLPVAATAH
//

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