(data stored in ACNUC1104 zone)

SWISSPROT: E6V290_VARPE

ID   E6V290_VARPE            Unreviewed;       435 AA.
AC   E6V290;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 46.
DE   SubName: Full=Homogentisate 1,2-dioxygenase {ECO:0000313|EMBL:ADU34521.1};
DE            EC=1.13.11.5 {ECO:0000313|EMBL:ADU34521.1};
GN   OrderedLocusNames=Varpa_0299 {ECO:0000313|EMBL:ADU34521.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34521.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34521.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34521.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|SAAS:SAAS00172633};
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
CC       {ECO:0000256|SAAS:SAAS00570051}.
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DR   EMBL; CP002417; ADU34521.1; -; Genomic_DNA.
DR   RefSeq; WP_013538767.1; NC_014931.1.
DR   STRING; 595537.Varpa_0299; -.
DR   EnsemblBacteria; ADU34521; ADU34521; Varpa_0299.
DR   GeneID; 29716348; -.
DR   KEGG; vpe:Varpa_0299; -.
DR   eggNOG; ENOG4105F1J; Bacteria.
DR   eggNOG; COG3508; LUCA.
DR   HOGENOM; HOG000139824; -.
DR   KO; K00451; -.
DR   OMA; RGYLCEN; -.
DR   OrthoDB; 193687at2; -.
DR   BioCyc; VPAR595537:G1GQO-301-MONOMER; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:InterPro.
DR   GO; GO:0006570; P:tyrosine metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR11056; PTHR11056; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6V290.
DR   SWISS-2DPAGE; E6V290.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   Dioxygenase {ECO:0000256|SAAS:SAAS00459208,
KW   ECO:0000313|EMBL:ADU34521.1}; Iron {ECO:0000256|SAAS:SAAS00459182};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00459204};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00459188,
KW   ECO:0000313|EMBL:ADU34521.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917}.
SQ   SEQUENCE   435 AA;  47999 MW;  A4C3AE63019CFB90 CRC64;
     MTDIPATERR YLGGFGNEYA SEAVPGALPQ GRNNPQRGPF DLYTELLSGT AFTAPRHENR
     RTWLYRRQPS VVSGRYQPYA QPHWTTGGAR EIALPPEPMR WHPMPLDGAA EADFIDGMHT
     VAANGDAESQ VGIGSLMYLA GRSMDKRAFV NADGEMLVVP QQGRLVITTE LGVLDVKPGE
     IAVLPRGMVF KVALPDGLSR GYVCENYGAH FRLPELGPIG SNGLANARDF QAPVAAFEED
     GGAYELVKKF AGRFWKAPTK QSPFNVVAWH GNLAPVKYDT ARFMAIGSIS FDHPDPSIFT
     VLTSPSDTPG TANCDFVIFP PRWMVMENTF RPPWFHRNLM SEFMGLVLGE YDAKPGGFKP
     GGASLHNCMV PHGPDEEAFD KATHADLKPH KLDNTLAFMF ESRFRFIPTN FALKSPALDT
     DYADCWAGLK DQFKP
//

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