(data stored in ACNUC7421 zone)

SWISSPROT: E6S609_INTC7

ID   E6S609_INTC7            Unreviewed;       460 AA.
AC   E6S609;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 41.
DE   SubName: Full=Pyridine nucleotide-disulfide oxidoreductase dimerization region {ECO:0000313|EMBL:ADU46749.1};
GN   OrderedLocusNames=Intca_0191 {ECO:0000313|EMBL:ADU46749.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46749.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46749.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000350-3};
CC       Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR000350-3};
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DR   EMBL; CP002343; ADU46749.1; -; Genomic_DNA.
DR   RefSeq; WP_013491071.1; NC_014830.1.
DR   STRING; 710696.Intca_0191; -.
DR   EnsemblBacteria; ADU46749; ADU46749; Intca_0191.
DR   KEGG; ica:Intca_0191; -.
DR   eggNOG; ENOG4107RVZ; Bacteria.
DR   eggNOG; COG1249; LUCA.
DR   HOGENOM; HOG000276709; -.
DR   OrthoDB; 267896at2; -.
DR   BioCyc; ICAL710696:GH9U-195-MONOMER; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.390.30; -; 1.
DR   Gene3D; 3.50.50.60; -; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   InterPro; IPR001100; Pyr_nuc-diS_OxRdtase.
DR   InterPro; IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   Pfam; PF02852; Pyr_redox_dim; 1.
DR   PIRSF; PIRSF000350; Mercury_reductase_MerA; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   SUPFAM; SSF55424; SSF55424; 1.
PE   4: Predicted;
DR   PRODOM; E6S609.
DR   SWISS-2DPAGE; E6S609.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   FAD {ECO:0000256|PIRSR:PIRSR000350-3};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR000350-3};
KW   NAD {ECO:0000256|PIRSR:PIRSR000350-3};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000350-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914}.
FT   DOMAIN        4    320       Pyr_redox_2. {ECO:0000259|Pfam:PF07992}.
FT   DOMAIN      343    451       Pyr_redox_dim. {ECO:0000259|Pfam:
FT                                PF02852}.
FT   NP_BIND     177    184       NAD. {ECO:0000256|PIRSR:PIRSR000350-3}.
FT   BINDING      50     50       FAD. {ECO:0000256|PIRSR:PIRSR000350-3}.
FT   BINDING     115    115       FAD; via amide nitrogen and carbonyl
FT                                oxygen. {ECO:0000256|PIRSR:PIRSR000350-
FT                                3}.
FT   BINDING     200    200       NAD. {ECO:0000256|PIRSR:PIRSR000350-3}.
FT   BINDING     269    269       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR000350-3}.
FT   BINDING     308    308       FAD. {ECO:0000256|PIRSR:PIRSR000350-3}.
FT   DISULFID     41     46       Redox-active. {ECO:0000256|PIRSR:
FT                                PIRSR000350-4}.
SQ   SEQUENCE   460 AA;  47685 MW;  9F6149D66DB7EB91 CRC64;
     MESFDIIVVG MGPGGEHVAN TLAERGLRVL GVDHGLVGGE CPYWGCIPTK MMVRAADALA
     EARRVDGLAG SVADVTPDWS LVARRIRDEA TDGWDDQVAV ERFTQKGGTF LRGTGRVVGP
     GRVDVDGKPY AAGRGIVVNV GSRAATPPIE GLEGVPFWTN REFAEATALP GSLVVLGGGA
     IGCELAQVAA RFGTTVTVVE SAPRLLSPEE PEASERIATV FEREGITVHV GSAAATVAAS
     PTPGEADQVE VTLEDGTVLR AERLLVATGR RTDPGAVGLG SVGVAADARV APTDEWCRVA
     PGVWAVGDIT GKGAFTHVSM YQAAIVVRDV LGEAGPPADY RAVPRVTFTD PEVATVGLTE
     AQARDQGVEV RTGFTALGST TRGWIHGVGG DGFIKLVADP GRGLLVGATV MGPAAGEVMG
     ALAVAVHAEV PLDRLRSMIH AYPTFHRGIE DALADLDQRS
//

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