(data stored in ACNUC7421 zone)

SWISSPROT: E6S8L7_INTC7

ID   E6S8L7_INTC7            Unreviewed;      1090 AA.
AC   E6S8L7;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   13-FEB-2019, entry version 50.
DE   SubName: Full=PAS/PAC sensor hybrid histidine kinase {ECO:0000313|EMBL:ADU46986.1};
GN   OrderedLocusNames=Intca_0438 {ECO:0000313|EMBL:ADU46986.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46986.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46986.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
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DR   EMBL; CP002343; ADU46986.1; -; Genomic_DNA.
DR   RefSeq; WP_013491307.1; NC_014830.1.
DR   STRING; 710696.Intca_0438; -.
DR   EnsemblBacteria; ADU46986; ADU46986; Intca_0438.
DR   KEGG; ica:Intca_0438; -.
DR   eggNOG; ENOG4105BZU; Bacteria.
DR   eggNOG; ENOG410XNMH; LUCA.
DR   OrthoDB; 1755994at2; -.
DR   BioCyc; ICAL710696:GH9U-450-MONOMER; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00130; PAS; 1.
DR   CDD; cd00156; REC; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR005561; ANTAR.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03861; ANTAR; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF08448; PAS_4; 2.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM01012; ANTAR; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52172; SSF52172; 2.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 2.
DR   PROSITE; PS50921; ANTAR; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
DR   PRODOM; E6S8L7.
DR   SWISS-2DPAGE; E6S8L7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Kinase {ECO:0000313|EMBL:ADU46986.1};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Transferase {ECO:0000313|EMBL:ADU46986.1}.
FT   DOMAIN      341    558       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   DOMAIN      622    737       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   DOMAIN      746    787       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN      836    888       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN     1019   1080       ANTAR. {ECO:0000259|PROSITE:PS50921}.
FT   MOD_RES     670    670       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   1090 AA;  118645 MW;  CD40691BDF08345D CRC64;
     MTAAPRVPGR EIAPDHPGEL GARFATIDWS HTPLGPISEW PTELRGAVSI CLTSRFPMLV
     WWGPQYVMIY NDGYRPMLGR LKHPAALGSA GKEVWPEIWA TIGPMLDRVM ETGVATWSRD
     QKLILERNGY PEECYFTFSY SPITSEAGEV GGVFTAVTET TDHVLSERRL GTLGVLARRL
     GEATDAEHVR RLAAEVLLSN PQDHPVVAMV DAAALPDDPR DLDVPEELRA DVLAAATQAA
     TLQHQVHHDL PSPVHLHDSG LSVAGLHALP IALPGDEELS EVLVVGRSSQ RTWEPALATY
     LALCVTHLGT ALSAIRTLDT ERQRAETLEV LDAAKSSFFT NVSHELRTPL TLIAGPVAEA
     LGDPGLTPEQ RERLDLVQRN TVRLTRMVDA MLDFGRMAAN KLQPLPEPLD VALQTRTMAD
     SFTQAFDRAG LDFVVDCDHA PRTAHLDRDM YERVVLNLLS NALKYTPAGS VRLRLECSAD
     GFAVSVADTG IGIRRRDLAR IFERFEQLPR RGRARFQGGA GIGLAMVKQL TELMGGSVDV
     ESTLGRGSTF TIRLPWGTPP VESAEPADGR SITPRNADAF LAEAEGWYEP YAAEPAPRTS
     RPPAVAGSPA GSVPDGAAAR PRLLVAEDNR DMRTYLRGAL ESDYDVEMVP DGTTALQRAV
     ASRPDIVLAD AMMPGLDGFA LTRAIRMNAA VRDVPVIILS ARAAESDTTE GLTSGADDYV
     SKPFSVGDLK ARLASNLERS RARLRDAAWR RAVMESFQDA LLITDAEGEV VEVNDAFTQL
     LGFSADDGPF SVPHPWWPAV QTPTGVAEVD AVDVPPTDRA NVEQLLAQAL QGATITGREC
     RLVTKDHRDV WVRLSTREVE SVGGQPNYVV MSLQDVTREH AARARRQAAA ALSAEFGRAE
     DLEQVLEAAV TGFADLFDGD STVRALAGPE EHVFTAAGPV RRADLDDTLW ELLTAIEPEV
     PAPSDRVPGL LISPQNHPSS ECRVWVQFRR PRRVATDERI VGDLLGQAFA LAVDRVVAAT
     AFADRESHLS RAIESHRMIG QAIGILIERH RVTPAEAFTR LKQASQARNI KLREIASRVI
     ETGAEPDEAD
//

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