(data stored in ACNUC7421 zone)

SWISSPROT: E6S8R5_INTC7

ID   E6S8R5_INTC7            Unreviewed;       560 AA.
AC   E6S8R5;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Signal transduction histidine kinase regulating citrate/malate metabolism {ECO:0000313|EMBL:ADU47034.1};
GN   OrderedLocusNames=Intca_0487 {ECO:0000313|EMBL:ADU47034.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU47034.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU47034.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01118672};
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DR   EMBL; CP002343; ADU47034.1; -; Genomic_DNA.
DR   STRING; 710696.Intca_0487; -.
DR   EnsemblBacteria; ADU47034; ADU47034; Intca_0487.
DR   KEGG; ica:Intca_0487; -.
DR   eggNOG; ENOG4105CEQ; Bacteria.
DR   eggNOG; COG3290; LUCA.
DR   HOGENOM; HOG000241935; -.
DR   BioCyc; ICAL710696:GH9U-500-MONOMER; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00075; HATPase_c; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR016120; Sig_transdc_His_kin_SpoOB.
DR   InterPro; IPR039506; SPOB_a.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF14689; SPOB_a; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF103190; SSF103190; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   SUPFAM; SSF55890; SSF55890; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; E6S8R5.
DR   SWISS-2DPAGE; E6S8R5.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:ADU47034.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    194    213       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      354    553       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   560 AA;  60151 MW;  7D1B686EC27DEED9 CRC64;
     MKVEFFVVMR RLRRFTLAGQ LLVAQVAILL TVLIAVAFVS LAQSEATFTR TEGRRLFAIA
     EQLASHPLVR QELAPPQVIN ALPTVVQGTI TQYGLALVSV ADSRGVVKDS SDPTTEERQL
     PLGSERVRQG ASWTGPMELA GRRMLAAQTP VLYSPGTNVP AAGGLSPGTR LGTVMVAVEM
     PSVIDRLQGA SSYLLTYLGL ALALGGLGSW LLARRLKRQT LGLEPHEITG LAESREAMLF
     GLAEGVVALD TSNRITLVNN VAQRLLDLPE RAVGMSVSDL AIGPRLREVL LGQTGDEPDQ
     VVLRRGRVLV MNRMEVAKDG RPLGSVTTLR DRTELAALER EIGSFRSSTE LLRAQAHEFA
     NQLHTISGLI QLGEYDEVVR FVDSVSQHRA QLDLTVARRI QDTAVSALVM AKAAQATERR
     VELRVSDDTA LGRMSSVDSA DLAAVVGNLV DNAVDAAATA GGDERWVELA IHQDASSPRS
     TVEVMVSDSG PGVAPELVTE VFTHGFTTKA AEAGERGIGL ALTRLICQRR GGEVEVERTE
     EGATFIARLT VDSPALQESR
//

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