(data stored in ACNUC13479 zone)

SWISSPROT: LAX1_ARATH

ID   LAX1_ARATH              Reviewed;         488 AA.
AC   Q9LFB2; Q9SMW2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   30-AUG-2017, entry version 107.
DE   RecName: Full=Auxin transporter-like protein 1;
DE   AltName: Full=AUX1-like protein 1;
GN   Name=LAX1; OrderedLocusNames=At5g01240; ORFNames=F7J8_220;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX   DOI=10.1007/s003440010030;
RA   Parry P.G., Marchant A., May S.T., Swarup R., Swarup K., James N.,
RA   Graham N., Allen T., Martucci T., Yemm A., Napier R., Manning K.,
RA   King G., Bennett M.J.;
RT   "Quick on the uptake: characterization of a family of plant auxin
RT   influx carriers.";
RL   J. Plant Growth Regul. 20:217-225(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
RA   Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
RA   Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
RA   van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
RA   Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
RA   Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
RA   Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Carrier protein involved in proton-driven auxin influx.
CC       Mediates the formation of auxin gradient from developing leaves
CC       (site of auxin biosynthesis) to tips by contributing to the
CC       loading of auxin in vascular tissues and facilitating acropetal
CC       (base to tip) auxin transport within inner tissues of the root
CC       apex, and basipetal (tip to base) auxin transport within outer
CC       tissues of the root apex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q9LFB2-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2
CC       family. Amino acid/auxin permease (AAAP) (TC 2.A.18.1) subfamily.
CC       {ECO:0000305}.
DR   EMBL; AJ249442; CAB55758.1; -; mRNA.
DR   EMBL; AL137189; CAB69852.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED90315.1; -; Genomic_DNA.
DR   PIR; T45964; T45964.
DR   RefSeq; NP_195744.1; NM_120202.5. [Q9LFB2-1]
DR   UniGene; At.67248; -.
DR   UniGene; At.9820; -.
DR   ProteinModelPortal; Q9LFB2; -.
DR   BioGrid; 17142; 1.
DR   MINT; MINT-8066356; -.
DR   STRING; 3702.AT5G01240.1; -.
DR   iPTMnet; Q9LFB2; -.
DR   PaxDb; Q9LFB2; -.
DR   PRIDE; Q9LFB2; -.
DR   EnsemblPlants; AT5G01240.1; AT5G01240.1; AT5G01240. [Q9LFB2-1]
DR   GeneID; 831866; -.
DR   Gramene; AT5G01240.1; AT5G01240.1; AT5G01240.
DR   KEGG; ath:AT5G01240; -.
DR   Araport; AT5G01240; -.
DR   TAIR; locus:2150089; AT5G01240.
DR   eggNOG; KOG1303; Eukaryota.
DR   eggNOG; COG0814; LUCA.
DR   HOGENOM; HOG000238482; -.
DR   InParanoid; Q9LFB2; -.
DR   KO; K13946; -.
DR   OMA; ICLRAIV; -.
DR   OrthoDB; EOG0936078P; -.
DR   PhylomeDB; Q9LFB2; -.
DR   PRO; PR:Q9LFB2; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LFB2; baseline and differential.
DR   Genevisible; Q9LFB2; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0010328; F:auxin influx transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0048829; P:root cap development; IGI:TAIR.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9LFB2.
DR   SWISS-2DPAGE; Q9LFB2.
KW   Alternative splicing; Amino-acid transport; Auxin signaling pathway;
KW   Cell membrane; Complete proteome; Glycoprotein; Membrane;
KW   Reference proteome; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    488       Auxin transporter-like protein 1.
FT                                /FTId=PRO_0000093842.
FT   TOPO_DOM      1     64       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     65     82       Helical. {ECO:0000255}.
FT   TOPO_DOM     83     84       Extracellular. {ECO:0000255}.
FT   TRANSMEM     85    105       Helical. {ECO:0000255}.
FT   TOPO_DOM    106    141       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    142    162       Helical. {ECO:0000255}.
FT   TOPO_DOM    163    178       Extracellular. {ECO:0000255}.
FT   TRANSMEM    179    199       Helical. {ECO:0000255}.
FT   TOPO_DOM    200    202       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    203    223       Helical. {ECO:0000255}.
FT   TOPO_DOM    224    238       Extracellular. {ECO:0000255}.
FT   TRANSMEM    239    259       Helical. {ECO:0000255}.
FT   TOPO_DOM    260    273       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    274    294       Helical. {ECO:0000255}.
FT   TOPO_DOM    295    320       Extracellular. {ECO:0000255}.
FT   TRANSMEM    321    341       Helical. {ECO:0000255}.
FT   TOPO_DOM    342    362       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    363    383       Helical. {ECO:0000255}.
FT   TOPO_DOM    384    384       Extracellular. {ECO:0000255}.
FT   TRANSMEM    385    405       Helical. {ECO:0000255}.
FT   TOPO_DOM    406    427       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    428    448       Helical. {ECO:0000255}.
FT   TOPO_DOM    449    488       Extracellular. {ECO:0000255}.
FT   CARBOHYD    303    303       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT     16     17       ED -> DE (in Ref. 1; CAB55758).
FT                                {ECO:0000305}.
FT   CONFLICT    293    293       V -> L (in Ref. 1; CAB55758).
FT                                {ECO:0000305}.
FT   CONFLICT    365    366       VV -> C (in Ref. 1; CAB55758).
FT                                {ECO:0000305}.
FT   CONFLICT    372    373       LA -> WP (in Ref. 1; CAB55758).
FT                                {ECO:0000305}.
FT   CONFLICT    379    381       FGP -> SA (in Ref. 1; CAB55758).
FT                                {ECO:0000305}.
FT   CONFLICT    413    416       RRNA -> AER (in Ref. 1; CAB55758).
FT                                {ECO:0000305}.
SQ   SEQUENCE   488 AA;  54601 MW;  06B0BF524EDE2BD8 CRC64;
     MSGEKQAEES IVVSGEDEVA GRKVEDSAAE EDIDGNGGNG FSMKSFLWHG GSAWDAWFSC
     ASNQVAQVLL TLPYSFSQLG MLSGILLQIF YGLMGSWTAY LISVLYVEYR ARMEKQEAKS
     FKNHVIQWFE VLDGLLGPYW KAAGLAFNCT FLLFGSVIQL IACASNIYYI NDRLDKRTWT
     YIFGACCATT VFIPSFHNYR IWSFLGLGMT TYTAWYLTIA SFLHGQAEGV THSGPTKLVL
     YFTGATNILY TFGGHAVTVE IMHAMWKPRK FKSIYLMATL YVFTLTLPSA SAVYWAFGDQ
     LLNHSNAFSL LPKTRFRDTA VILMLIHQFI TFGFACTPLY FVWEKAIGMH HTKSLCLRAL
     VRLPVVVPIW FLAIIFPFFG PINSAVGALL VTFTVYIIPA LAHMLTYRTA SARRNAAEKP
     PFFIPSWAGV YVINAFIVVW VLVLGFGFGG WASMTNFIRQ IDTFGLFAKC YQCKPPPAPI
     AAGAHHRR
//

If you have problems or comments...

PBIL Back to PBIL home page