(data stored in ACNUC13479 zone)

SWISSPROT: SFC1_ARATH

ID   SFC1_ARATH              Reviewed;         309 AA.
AC   Q9M038; Q8LAN8;
DT   09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   07-JUN-2017, entry version 117.
DE   RecName: Full=Mitochondrial succinate-fumarate transporter 1;
DE            Short=AtMSFC1;
GN   Name=SFC1; OrderedLocusNames=At5g01340; ORFNames=T10O8.50;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
RA   Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
RA   Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
RA   van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
RA   Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
RA   Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
RA   Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=12527366; DOI=10.1016/S0014-5793(02)03782-1;
RA   Catoni E., Schwab R., Hilpert M., Desimone M., Schwacke R.,
RA   Fluegge U.I., Schumacher K., Frommer W.B.;
RT   "Identification of an Arabidopsis mitochondrial succinate-fumarate
RT   translocator.";
RL   FEBS Lett. 534:87-92(2003).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=15003237; DOI=10.1016/j.tplants.2004.01.007;
RA   Picault N., Hodges M., Palmieri L., Palmieri F.;
RT   "The growing family of mitochondrial carriers in Arabidopsis.";
RL   Trends Plant Sci. 9:138-146(2004).
CC   -!- FUNCTION: May transport cytoplasmic succinate, derived from fatty
CC       acid oxidation, into the mitochondrial matrix in exchange of
CC       fumarate during lipid mobilization in seed germination. Conversion
CC       of seed-reserved triacylglycerols into sucrose is necessary for
CC       growth before the onset of photosynthesis and involves fatty acid
CC       beta-oxidation, the glyoxylate cycle and gluconeogenesis.
CC       {ECO:0000269|PubMed:12527366}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in root tips, cotyledons,
CC       hypocotyls, leaves, trichomes, stems, flowers, carpels, anthers,
CC       pollen and abcission zone of siliques.
CC       {ECO:0000269|PubMed:12527366}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM65239.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
DR   EMBL; AL161746; CAB81917.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED90329.1; -; Genomic_DNA.
DR   EMBL; AY052716; AAK96620.1; -; mRNA.
DR   EMBL; AY098957; AAM19967.1; -; mRNA.
DR   EMBL; AY087702; AAM65239.1; ALT_INIT; mRNA.
DR   PIR; T48156; T48156.
DR   RefSeq; NP_195754.1; NM_120212.3.
DR   UniGene; At.4677; -.
DR   ProteinModelPortal; Q9M038; -.
DR   BioGrid; 16755; 1.
DR   STRING; 3702.AT5G01340.1; -.
DR   PaxDb; Q9M038; -.
DR   PRIDE; Q9M038; -.
DR   EnsemblPlants; AT5G01340.1; AT5G01340.1; AT5G01340.
DR   GeneID; 831479; -.
DR   Gramene; AT5G01340.1; AT5G01340.1; AT5G01340.
DR   KEGG; ath:AT5G01340; -.
DR   Araport; AT5G01340; -.
DR   TAIR; locus:2179152; AT5G01340.
DR   eggNOG; KOG0756; Eukaryota.
DR   eggNOG; ENOG410YAYP; LUCA.
DR   HOGENOM; HOG000168307; -.
DR   InParanoid; Q9M038; -.
DR   KO; K15100; -.
DR   OMA; LESTMWR; -.
DR   OrthoDB; EOG09360HRI; -.
DR   PhylomeDB; Q9M038; -.
DR   Reactome; R-ATH-70263; Gluconeogenesis.
DR   Reactome; R-ATH-75105; Fatty acyl-CoA biosynthesis.
DR   PRO; PR:Q9M038; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   Genevisible; Q9M038; AT.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015141; F:succinate transmembrane transporter activity; IGI:TAIR.
DR   GO; GO:0015741; P:fumarate transport; IBA:GO_Central.
DR   GO; GO:0006839; P:mitochondrial transport; IBA:GO_Central.
DR   GO; GO:0015744; P:succinate transport; IGI:TAIR.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9M038.
DR   SWISS-2DPAGE; Q9M038.
KW   Complete proteome; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    309       Mitochondrial succinate-fumarate
FT                                transporter 1.
FT                                /FTId=PRO_0000420760.
FT   TRANSMEM     17     37       Helical; Name=1. {ECO:0000255}.
FT   TRANSMEM     65     85       Helical; Name=2. {ECO:0000255}.
FT   TRANSMEM    111    131       Helical; Name=3. {ECO:0000255}.
FT   TRANSMEM    171    191       Helical; Name=4. {ECO:0000255}.
FT   TRANSMEM    214    234       Helical; Name=5. {ECO:0000255}.
FT   TRANSMEM    273    293       Helical; Name=6. {ECO:0000255}.
FT   REPEAT       11     96       Solcar 1.
FT   REPEAT      108    196       Solcar 2.
FT   REPEAT      208    298       Solcar 3.
FT   CONFLICT     58     58       K -> T (in Ref. 4; AAM65239).
FT                                {ECO:0000305}.
SQ   SEQUENCE   309 AA;  33991 MW;  6888B8D99E22357C CRC64;
     MATRTESKKQ IPPYMKAVSG SLGGVVEACC LQPIDVIKTR LQLDRVGAYK GIAHCGSKVV
     RTEGVRALWK GLTPFATHLT LKYTLRMGSN AMFQTAFKDS ETGKVSNRGR FLSGFGAGVL
     EALAIVTPFE VVKIRLQQQK GLSPELFKYK GPIHCARTIV REESILGLWS GAAPTVMRNG
     TNQAVMFTAK NAFDILLWNK HEGDGKILQP WQSMISGFLA GTAGPFCTGP FDVVKTRLMA
     QSRDSEGGIR YKGMVHAIRT IYAEEGLVAL WRGLLPRLMR IPPGQAIMWA VADQVTGLYE
     MRYLRNAPL
//

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