(data stored in ACNUC13479 zone)

SWISSPROT: Q8GXW0_ARATH

ID   Q8GXW0_ARATH            Unreviewed;       322 AA.
AC   Q8GXW0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   05-JUL-2017, entry version 109.
DE   SubName: Full=At5g01670 {ECO:0000313|EMBL:ABN04834.1};
DE   SubName: Full=NAD(P)-linked oxidoreductase superfamily protein {ECO:0000313|EMBL:AED90374.1};
DE   SubName: Full=Putative aldose reductase {ECO:0000313|EMBL:BAC42643.1};
GN   OrderedLocusNames=At5g01670 {ECO:0000313|Araport:AT5G01670,
GN   ECO:0000313|EMBL:AED90374.1}, At5g01670/F7A7_190
GN   {ECO:0000313|EMBL:BAC42643.1};
GN   ORFNames=F7A7.190 {ECO:0000313|EMBL:AED90374.1}, F7A7_190
GN   {ECO:0000313|EMBL:AED90374.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000313|EMBL:BAC42643.1};
RN   [1] {ECO:0000313|EMBL:AED90374.1, ECO:0000313|Proteomes:UP000006548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX   PubMed=11130714; DOI=10.1038/35048507;
RG   Kazusa DNA Research Institute;
RG   Cold Spring Harbor and Washington University in St Louis Sequencing Consortium;
RG   European Union Arabidopsis Genome Sequencing Consortium;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., See L.H., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Dusterhoft A., Stiekema W., Pohl T.,
RA   Entian K.D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Lankhorst R.K., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.W.,
RA   Bevan M., Fransz P.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [2] {ECO:0000313|EMBL:BAC42643.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Seki M., Iida K., Satou M., Sakurai T., Akiyama K., Ishida J.,
RA   Nakajima M., Enju A., Kamiya A., Narusaka M., Carninci P., Kawai J.,
RA   Hayashizaki Y., Shinozaki K.;
RT   "Arabidopsis thaliana full-length cDNA.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ABN04834.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kim C.J., Bautista V.R., Chen H., De Los Reyes C., Wu S.Y.,
RA   Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AED90374.1}
RP   NUCLEOTIDE SEQUENCE.
RG   TAIR;
RA   Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AED90374.1, ECO:0000313|Proteomes:UP000006548}
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BT030096; ABN04834.1; -; mRNA.
DR   EMBL; CP002688; AED90374.1; -; Genomic_DNA.
DR   EMBL; AK118010; BAC42643.1; -; mRNA.
DR   RefSeq; NP_195787.2; NM_120245.4.
DR   UniGene; At.4700; -.
DR   SMR; Q8GXW0; -.
DR   EnsemblPlants; AT5G01670.1; AT5G01670.1; AT5G01670.
DR   GeneID; 831701; -.
DR   Gramene; AT5G01670.1; AT5G01670.1; AT5G01670.
DR   KEGG; ath:AT5G01670; -.
DR   Araport; AT5G01670; -.
DR   HOGENOM; HOG000250272; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q8GXW0; baseline and differential.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd06660; Aldo_ket_red; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR020471; Aldo/keto_reductase.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   PANTHER; PTHR11732; PTHR11732; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q8GXW0.
DR   SWISS-2DPAGE; Q8GXW0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006548};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT   DOMAIN       27    291       Aldo_ket_red. {ECO:0000259|Pfam:PF00248}.
FT   ACT_SITE     60     60       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000097-1}.
FT   BINDING     121    121       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000097-2}.
FT   SITE         88     88       Lowers pKa of active site Tyr.
FT                                {ECO:0000256|PIRSR:PIRSR000097-3}.
SQ   SEQUENCE   322 AA;  36581 MW;  1FEBF78459700FA2 CRC64;
     MAHATFTSEG QNMESFRLLS GHKIPAVGLG TWRSGSQAAH AVVTAIVEGG YRHIDTAWEY
     GDQREVGQGI KRAMHAGLER RDLFVTSKLW CTELSPERVR PALQNTLKEL QLEYLDLYLI
     HWPIRLREGA SKPPKAGDVL DFDMEGVWRE MENLSKDSLV RNIGVCNFTV TKLNKLLGFA
     ELIPAVCQME MHPGWRNDRI LEFCKKNEIH VTAYSPLGSQ EGGRDLIHDQ TVDRIAKKLN
     KTPGQILVKW GLQRGTSVIP KSLNPERIKE NIKVFDWVIP EQDFQALNSI TDQKRVIDGE
     DLFVNKTEGP FRSVADLWDH ED
//

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