(data stored in ACNUC13479 zone)

SWISSPROT: F4K9G7_ARATH

ID   F4K9G7_ARATH            Unreviewed;       349 AA.
AC   F4K9G7;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   SubName: Full=NAD(P)-linked oxidoreductase superfamily protein {ECO:0000313|EMBL:AED90375.1};
GN   OrderedLocusNames=At5g01670 {ECO:0000313|Araport:AT5G01670,
GN   ECO:0000313|EMBL:AED90375.1};
GN   ORFNames=F7A7.190 {ECO:0000313|EMBL:AED90375.1}, F7A7_190
GN   {ECO:0000313|EMBL:AED90375.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000313|EMBL:AED90375.1, ECO:0000313|Proteomes:UP000006548};
RN   [1] {ECO:0000313|EMBL:AED90375.1, ECO:0000313|Proteomes:UP000006548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX   PubMed=11130714; DOI=10.1038/35048507;
RG   Kazusa DNA Research Institute;
RG   Cold Spring Harbor and Washington University in St Louis Sequencing Consortium;
RG   European Union Arabidopsis Genome Sequencing Consortium;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., See L.H., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Dusterhoft A., Stiekema W., Pohl T.,
RA   Entian K.D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Lankhorst R.K., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.W.,
RA   Bevan M., Fransz P.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [2] {ECO:0000313|Proteomes:UP000006548}
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
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DR   EMBL; CP002688; AED90375.1; -; Genomic_DNA.
DR   RefSeq; NP_850750.1; NM_180419.2.
DR   SMR; F4K9G7; -.
DR   STRING; 3702.AT5G01670.2; -.
DR   PaxDb; F4K9G7; -.
DR   EnsemblPlants; AT5G01670.2; AT5G01670.2; AT5G01670.
DR   GeneID; 831701; -.
DR   Gramene; AT5G01670.2; AT5G01670.2; AT5G01670.
DR   Araport; AT5G01670; -.
DR   TAIR; locus:2149715; AT5G01670.
DR   eggNOG; KOG1577; Eukaryota.
DR   eggNOG; COG0656; LUCA.
DR   InParanoid; F4K9G7; -.
DR   OrthoDB; 1016440at2759; -.
DR   PhylomeDB; F4K9G7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4K9G7; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IBA:GO_Central.
DR   GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   CDD; cd06660; Aldo_ket_red; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR020471; Aldo/keto_reductase.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; PTHR11732; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
DR   PRODOM; F4K9G7.
DR   SWISS-2DPAGE; F4K9G7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006548};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT   DOMAIN       27    318       Aldo_ket_red. {ECO:0000259|Pfam:PF00248}.
FT   ACT_SITE     60     60       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000097-1}.
FT   BINDING     148    148       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000097-2}.
FT   SITE         88     88       Lowers pKa of active site Tyr.
FT                                {ECO:0000256|PIRSR:PIRSR000097-3}.
SQ   SEQUENCE   349 AA;  39655 MW;  749D4C3E6A69F0DF CRC64;
     MAHATFTSEG QNMESFRLLS GHKIPAVGLG TWRSGSQAAH AVVTAIVEGG YRHIDTAWEY
     GDQREVGQGI KRAMHAGLER RDLFVTSKLW YTLILRKMIN LSSPLMNVLV GTCLNKRCTE
     LSPERVRPAL QNTLKELQLE YLDLYLIHWP IRLREGASKP PKAGDVLDFD MEGVWREMEN
     LSKDSLVRNI GVCNFTVTKL NKLLGFAELI PAVCQMEMHP GWRNDRILEF CKKNEIHVTA
     YSPLGSQEGG RDLIHDQTVD RIAKKLNKTP GQILVKWGLQ RGTSVIPKSL NPERIKENIK
     VFDWVIPEQD FQALNSITDQ KRVIDGEDLF VNKTEGPFRS VADLWDHED
//

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