(data stored in ACNUC13479 zone)

SWISSPROT: CHX26_ARATH

ID   CHX26_ARATH             Reviewed;         784 AA.
AC   Q9M008;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   05-JUL-2017, entry version 79.
DE   RecName: Full=Cation/H(+) antiporter 26;
DE   AltName: Full=Protein CATION/H+ EXCHANGER 26;
DE            Short=AtCHX26;
GN   Name=CHX26; OrderedLocusNames=At5g01680; ORFNames=F7A7_200;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
RA   Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
RA   Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
RA   van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
RA   Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
RA   Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
RA   Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA   Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA   Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA   Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A.,
RA   Guerinot M.L.;
RT   "Phylogenetic relationships within cation transporter families of
RT   Arabidopsis.";
RL   Plant Physiol. 126:1646-1667(2001).
RN   [4]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15347787; DOI=10.1104/pp.104.046003;
RA   Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA   Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT   "Expression patterns of a novel AtCHX gene family highlight potential
RT   roles in osmotic adjustment and K+ homeostasis in pollen
RT   development.";
RL   Plant Physiol. 136:2532-2547(2004).
CC   -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in pollen.
CC       {ECO:0000269|PubMed:15347787}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2
CC       (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4)
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB82284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AL161946; CAB82284.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED90376.1; -; Genomic_DNA.
DR   PIR; T48189; T48189.
DR   RefSeq; NP_195788.2; NM_120246.2.
DR   UniGene; At.54676; -.
DR   ProteinModelPortal; Q9M008; -.
DR   STRING; 3702.AT5G01680.1; -.
DR   TCDB; 2.A.37.4.6; the monovalent cation:proton antiporter-2 (cpa2) family.
DR   PaxDb; Q9M008; -.
DR   EnsemblPlants; AT5G01680.1; AT5G01680.1; AT5G01680.
DR   GeneID; 831698; -.
DR   Gramene; AT5G01680.1; AT5G01680.1; AT5G01680.
DR   KEGG; ath:AT5G01680; -.
DR   Araport; AT5G01680; -.
DR   TAIR; locus:2149740; AT5G01680.
DR   eggNOG; KOG1650; Eukaryota.
DR   eggNOG; COG0475; LUCA.
DR   HOGENOM; HOG000176589; -.
DR   InParanoid; Q9M008; -.
DR   OMA; GHNDESS; -.
DR   OrthoDB; EOG0936128R; -.
DR   PhylomeDB; Q9M008; -.
DR   PRO; PR:Q9M008; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   Genevisible; Q9M008; AT.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0015672; P:monovalent inorganic cation transport; IBA:GO_Central.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9M008.
DR   SWISS-2DPAGE; Q9M008.
KW   Antiport; Complete proteome; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    784       Cation/H(+) antiporter 26.
FT                                /FTId=PRO_0000394995.
FT   TRANSMEM     38     58       Helical. {ECO:0000255}.
FT   TRANSMEM     61     81       Helical. {ECO:0000255}.
FT   TRANSMEM     97    117       Helical. {ECO:0000255}.
FT   TRANSMEM    130    150       Helical. {ECO:0000255}.
FT   TRANSMEM    201    221       Helical. {ECO:0000255}.
FT   TRANSMEM    240    260       Helical. {ECO:0000255}.
FT   TRANSMEM    286    306       Helical. {ECO:0000255}.
FT   TRANSMEM    321    341       Helical. {ECO:0000255}.
FT   TRANSMEM    351    371       Helical. {ECO:0000255}.
FT   TRANSMEM    376    396       Helical. {ECO:0000255}.
FT   TRANSMEM    413    433       Helical. {ECO:0000255}.
SQ   SEQUENCE   784 AA;  87038 MW;  CE76C7FD89F6BB9B CRC64;
     MNNSVTSNGT HEFVCEAWLG SSSGGLLRGD DPLKYSTPLL LLLISLVSSL SSVFQALLRP
     LANVDFVTQI LAGIFLGPSA LGQNIDLVKK LFNTRSYFII ESFEAISFMF ISYISTAQVD
     MGVIKRGGKL AIINGLSLFL FPYVVGAIAC TVITSNIRGT VAKNNPEQLH NLLTNQSVVY
     FQVAYSVLSN LKMLNSEPGR LALSSIMVAN CFGWGFFLLL ITFDSFLHQN YSKTTYLPTF
     TKVLLLVGIV VVCRPIFNWI VKRTPEGKKL KASHLCTICV MLCTATFLSE TVGFPYVVGS
     VALGLVTPKT PPFGTGLTDK IGSFCYAVLM PCYVIGIGNK VDFFSFNLRD IISLEFLIFT
     ISAAKFASIV LPSLYFQVPI SHAVIVGFIV CIQGIYDVQI FKQLLNYKNI SHEAFGIMVI
     SAMVHSTIFT AIVKNLYGWV QRKHITYRRQ TVQHYEPNKP LKILTCFYHR ETVPPILTVL
     ELSTCPSSAS SHSIVSVNLE ELEQNNVPLL IQHHPGHNDE SSTSSSRRDQ ISKAFEKFRS
     GHDLQENVSV ECFTAVAPSK TMHEDVCALA FEKETDLIIF GMADGTAAER RLCRNVRNAS
     PSSVAVLMDQ GRLPDFKNMG TAMKNGSMRI NICSIFLGGA DDRETLAFAV RMTNQPYVNL
     TVLKLVDGEN VSHLNDVVEK RLDFRTIEKF RQDTMNKHNV ALREVWIKEA SDLVNLLREE
     GNNYDLIMVG IRHEKSFEVL QGLSVWSEIE ELGEIGDLLV SRDLKLSASV LAVQQQLSSV
     VEEV
//

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