(data stored in ACNUC13479 zone)

SWISSPROT: TOL7_ARATH

ID   TOL7_ARATH              Reviewed;         542 AA.
AC   F4KAU9; Q8GWW0; Q9LZX0;
DT   05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   30-AUG-2017, entry version 49.
DE   RecName: Full=TOM1-like protein 7 {ECO:0000305};
GN   Name=TOL7 {ECO:0000303|PubMed:24316203};
GN   Synonyms=TOM1B {ECO:0000303|PubMed:22639582};
GN   OrderedLocusNames=At5g01760 {ECO:0000312|Araport:AT5G01760};
GN   ORFNames=T20L15.30 {ECO:0000312|EMBL:CAB82746.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
RA   Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
RA   Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
RA   van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
RA   Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
RA   Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
RA   Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
RA   Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
RA   Shibata K., Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   GENE FAMILY, AND REVIEW.
RX   PubMed=16488176; DOI=10.1016/j.tplants.2006.01.008;
RA   Winter V., Hauser M.-T.;
RT   "Exploring the ESCRTing machinery in eukaryotes.";
RL   Trends Plant Sci. 11:115-123(2006).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=22639582; DOI=10.3389/fpls.2011.00020;
RA   Richardson L.G., Howard A.S., Khuu N., Gidda S.K., McCartney A.,
RA   Morphy B.J., Mullen R.T.;
RT   "Protein-protein interaction network and subcellular localization of
RT   the Arabidopsis thaliana ESCRT machinery.";
RL   Front. Plant Sci. 2:20-20(2011).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24316203; DOI=10.1016/j.cub.2013.10.036;
RA   Korbei B., Moulinier-Anzola J., De-Araujo L., Lucyshyn D., Retzer K.,
RA   Khan M.A., Luschnig C.;
RT   "Arabidopsis TOL proteins act as gatekeepers for vacuolar sorting of
RT   PIN2 plasma membrane protein.";
RL   Curr. Biol. 23:2500-2505(2013).
RN   [7]
RP   TISSUE SPECIFICITY.
RX   PubMed=24699223;
RA   Moulinier-Anzola J., De-Araujo L., Korbei B.;
RT   "Expression of Arabidopsis TOL genes.";
RL   Plant Signal. Behav. 9:E28667-E28667(2014).
CC   -!- FUNCTION: Might contribute to the loading of the ESCRT machinery.
CC       {ECO:0000305|PubMed:16488176}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in flowers.
CC       {ECO:0000269|PubMed:24699223}.
CC   -!- SIMILARITY: Belongs to the TOM1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC43199.1; Type=Frameshift; Positions=119; Evidence={ECO:0000305};
CC       Sequence=BAC43199.1; Type=Miscellaneous discrepancy; Note=Introns retention.; Evidence={ECO:0000305};
CC       Sequence=CAB82746.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AL162351; CAB82746.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED90388.1; -; Genomic_DNA.
DR   EMBL; AK118600; BAC43199.1; ALT_SEQ; mRNA.
DR   PIR; T48197; T48197.
DR   RefSeq; NP_195796.2; NM_120254.3.
DR   UniGene; At.33510; -.
DR   ProteinModelPortal; F4KAU9; -.
DR   SMR; F4KAU9; -.
DR   STRING; 3702.AT5G01760.1; -.
DR   PaxDb; F4KAU9; -.
DR   PRIDE; F4KAU9; -.
DR   EnsemblPlants; AT5G01760.1; AT5G01760.1; AT5G01760.
DR   GeneID; 831682; -.
DR   Gramene; AT5G01760.1; AT5G01760.1; AT5G01760.
DR   KEGG; ath:AT5G01760; -.
DR   Araport; AT5G01760; -.
DR   TAIR; locus:2180982; AT5G01760.
DR   eggNOG; KOG1087; Eukaryota.
DR   eggNOG; ENOG410Y26G; LUCA.
DR   HOGENOM; HOG000241362; -.
DR   InParanoid; F4KAU9; -.
DR   OMA; SHIAEKH; -.
DR   OrthoDB; EOG0936064F; -.
DR   Reactome; R-ATH-432720; Lysosome Vesicle Biogenesis.
DR   Reactome; R-ATH-5689901; Metalloprotease DUBs.
DR   Reactome; R-ATH-6798695; Neutrophil degranulation.
DR   Proteomes; UP000006548; Chromosome 5.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.40.90; -; 1.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR004152; GAT_dom.
DR   InterPro; IPR002014; VHS_dom.
DR   Pfam; PF03127; GAT; 1.
DR   Pfam; PF00790; VHS; 1.
DR   SMART; SM00288; VHS; 1.
DR   SUPFAM; SSF48464; SSF48464; 1.
DR   PROSITE; PS50909; GAT; 1.
DR   PROSITE; PS50179; VHS; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; F4KAU9.
DR   SWISS-2DPAGE; F4KAU9.
KW   Complete proteome; Membrane; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN         1    542       TOM1-like protein 7.
FT                                /FTId=PRO_0000440682.
FT   DOMAIN       29    158       VHS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00218}.
FT   DOMAIN      201    289       GAT. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00373}.
FT   COMPBIAS      4     21       Ser-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00016}.
FT   COMPBIAS    306    333       Ser-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00016}.
FT   COMPBIAS    393    427       Thr-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00017}.
FT   COMPBIAS    422    493       Gln-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00006}.
FT   MOD_RES     161    161       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O80910}.
FT   MOD_RES     521    521       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O80910}.
SQ   SEQUENCE   542 AA;  59768 MW;  C3E8B2C4433A9986 CRC64;
     MRPSCASSSS SSASPSLRLS SVTVAVDKAT SELLRTPDWT IIIAICDSLN SNRWQCKDAI
     KAVKRRLQHK SSRVQLLTLT LLEAMLKNCG DFVHSHIAEK HLLEDMVKLV RKKGDFEVRN
     KLLILLDTWN EAFSGVACKH PHYNWAYQEL KRCGVKFPQR SKEAPLMLEP PPPVTQSSSS
     SSMNLMSIGS FRRLDETMAT EIESLSLSSL ESMRNVMDLV NDMVQAVNPS DKSALKDELI
     VDLVEQCRSN QKKLIQMLTT TADEDVLARG LELNDSLQVV LARHDAIASG VSLPLLLQAP
     EPRETSSSLK TCGAAALESA DSESSSSSSS SESETDEVED VKDDFIQLAK RHALLNALHS
     DEEEETLLLG NDNEKTAEAE AKTQCKDLAL FDTTTTTTTK SEQDIIELLS LTLSTTALPS
     PQTQPQTQHP SFFADDNILM NSYVVPWAQS QEEPQVPKMT QFAPSGPQFQ PWPLQQQQPY
     SYGYPQPQWS GGQVNSNDTT FWSQGGNENM VFERNLQVSN SFPARATGTS GAATAATVDR
     QP
//

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