(data stored in ACNUC13479 zone)

SWISSPROT: RTOR2_ARATH

ID   RTOR2_ARATH             Reviewed;        1336 AA.
AC   Q9LZW9;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   05-JUL-2017, entry version 132.
DE   RecName: Full=Regulatory-associated protein of TOR 2;
DE   AltName: Full=Protein RAPTOR 1A;
DE            Short=AtRaptor1a;
DE   AltName: Full=Protein RAPTOR 2;
GN   Name=RAPTOR2; Synonyms=RAPTOR1A; OrderedLocusNames=At5g01770;
GN   ORFNames=T20L15.40;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
RA   Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
RA   Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
RA   van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
RA   Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
RA   Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
RA   Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=15607746; DOI=10.1016/j.bbrc.2004.11.117;
RA   Deprost D., Truong H.N., Robaglia C., Meyer C.;
RT   "An Arabidopsis homolog of RAPTOR/KOG1 is essential for early embryo
RT   development.";
RL   Biochem. Biophys. Res. Commun. 326:844-850(2005).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=15845148; DOI=10.1186/1741-7007-3-12;
RA   Anderson G.H., Veit B., Hanson M.R.;
RT   "The Arabidopsis AtRaptor genes are essential for post-embryonic plant
RT   growth.";
RL   BMC Biol. 3:12-12(2005).
CC   -!- FUNCTION: Probable component of the plant TOR kinase pathway.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed at low levels in roots, leaves,
CC       flowers and seeds. {ECO:0000269|PubMed:15607746}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       condition. {ECO:0000269|PubMed:15607746,
CC       ECO:0000269|PubMed:15845148}.
CC   -!- SIMILARITY: Belongs to the WD repeat RAPTOR family. {ECO:0000305}.
DR   EMBL; AL162351; CAB82747.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED90389.1; -; Genomic_DNA.
DR   PIR; T48198; T48198.
DR   RefSeq; NP_195797.3; NM_120255.3.
DR   UniGene; At.54678; -.
DR   ProteinModelPortal; Q9LZW9; -.
DR   SMR; Q9LZW9; -.
DR   STRING; 3702.AT5G01770.1; -.
DR   iPTMnet; Q9LZW9; -.
DR   PaxDb; Q9LZW9; -.
DR   EnsemblPlants; AT5G01770.1; AT5G01770.1; AT5G01770.
DR   GeneID; 831681; -.
DR   Gramene; AT5G01770.1; AT5G01770.1; AT5G01770.
DR   KEGG; ath:AT5G01770; -.
DR   Araport; AT5G01770; -.
DR   TAIR; locus:2180997; AT5G01770.
DR   eggNOG; KOG1517; Eukaryota.
DR   eggNOG; ENOG410XQKJ; LUCA.
DR   InParanoid; Q9LZW9; -.
DR   KO; K07204; -.
DR   OMA; ESCLEAN; -.
DR   OrthoDB; EOG093600BH; -.
DR   Reactome; R-ATH-3371571; HSF1-dependent transactivation.
DR   PRO; PR:Q9LZW9; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   Genevisible; Q9LZW9; AT.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031931; C:TORC1 complex; IBA:GO_Central.
DR   GO; GO:0030674; F:protein binding, bridging; IBA:GO_Central.
DR   GO; GO:0016049; P:cell growth; IMP:TAIR.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR   GO; GO:0030307; P:positive regulation of cell growth; IBA:GO_Central.
DR   GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR   GO; GO:0008361; P:regulation of cell size; IBA:GO_Central.
DR   GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR004083; Raptor.
DR   InterPro; IPR029347; Raptor_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   PANTHER; PTHR12848; PTHR12848; 1.
DR   Pfam; PF14538; Raptor_N; 1.
DR   SMART; SM01302; Raptor_N; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9LZW9.
DR   SWISS-2DPAGE; Q9LZW9.
KW   Complete proteome; Reference proteome; Repeat; WD repeat.
FT   CHAIN         1   1336       Regulatory-associated protein of TOR 2.
FT                                /FTId=PRO_0000409333.
FT   REPEAT     1008   1047       WD 1.
FT   REPEAT     1053   1102       WD 2.
FT   REPEAT     1116   1155       WD 3.
FT   REPEAT     1159   1199       WD 4.
FT   REPEAT     1205   1246       WD 5.
FT   REPEAT     1250   1289       WD 6.
FT   REPEAT     1298   1336       WD 7.
SQ   SEQUENCE   1336 AA;  147640 MW;  7E6A5C25A4476D17 CRC64;
     MALGDLMVSR LSQSSVTVVT NHLYDDDDNC ASSAHDDSRV SIIASPRVAS SSYENLSAAT
     SMAYLPQTLV LCDLRHDDAS DIVQPPRWRL KERMKTGCVA LVMCLHITVD PPDVIKISPC
     ARLECWIDPF SMFPPRRALE AIGQNLSIQY ERWLARARYK VELDPTKDDV RKLCLSCRKY
     AKTERVLFHY NGHGVPKPTP NGEIWVYNKN FTQYIPLPVS ELDSWLKTPT IYVFDCSAAR
     VILNAFAEGE SSGPPKDCIL LAACDVHETL PQSVEFPADV FTSCLTTPIN IALKWFCRRS
     LLKEFIDESL IDRIPGRQND RKTLLGELNW IFTAVTDTIA WNVLPRELFQ RLFRQDLLVA
     SLFRNFLLAE RIMRSGNCTP ISHPMLPPTH QHHMWDAWDM AAEICLSQLP QFFLDPNTEF
     QPSSFFTEQL TAFEVWLDHG SEHKKPPEQL PIVLQVLLSQ CHRYRALVLL GRFLDMGPWA
     VDLALSVGIY PCVVKLLQTT TIELRQILVF IWTKILALDK SCQVDLVKDR GHIYFIRFLD
     SSDAFPEQRA MAAFILAVIV DGYKRGQESC LEANLIAVCL GHLEATQLCD PPPEPLFLQW
     LCLCLGKLWE DYLEAQIMGR EANASENLIA GHTNLLQVRA AAVFALGTLL DVGFDSGKGV
     CDEEFDDDEN IVEDIIIKSL LDVVSDGSPL VRTEVAVALA RFAFGHKQHL KSVADSYWKP
     QNSLRTSLPS MAKFHDSGTS IVASSDMGSL TRASPDSQPV AREGRISSSL QEPFSGLMQG
     SPLADDSSLH SDVGIIHDGV SNGVVHQPRP LDNAIYSQSV LAMFTLAKDP SPRIASLGRR
     VLSVIGIEQI VAKPSKSNGR PGEAASASHT PLAGLVRSSS WFDMHTGHLP LTFRTPPVSP
     PQTSYLTGLR RVCSLELRPH LLGSPDSGLA DPILGVSGSE RSLLPQSTIY NWSCGHFSKP
     LLGGADANEE IAAQREEKKK FSLEHIAKCQ HSSISGLSNI PIANWDTKFE TGTKTALLHP
     FSPIVVAADE NERIRVWNYE EATLLNGFDN NDFPDKGISN LCLVNELDDS LLLVASCNVP
     TLSRASFAIR IWKDYATKGR QKLVTGFSSI QGQKPGASGL NAVVDWQQQS GYLYVSGESL
     SIMVWDLDKE QLVKSMPFES GCSVTALSAS QVHGSQLAAG FADGSVRLYD VRTPDFLVCA
     TRPHQRVEKV VGLSFQPGLD PAKIVSASQA GDIQFLDLRR PKETYLTIDA HRGSLTALGV
     HRHAPIIASG SAKQLIKVFS LKGEQLGIIK YHTSFMGQQI GPVSCLAFHP YQMLLAAGAA
     GSFVSLYTHH NTQLPR
//

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