(data stored in ACNUC13479 zone)

SWISSPROT: PILS6_ARATH

ID   PILS6_ARATH             Reviewed;         431 AA.
AC   Q9LZN2;
DT   08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   07-JUN-2017, entry version 94.
DE   RecName: Full=Protein PIN-LIKES 6 {ECO:0000303|PubMed:22504182};
DE   AltName: Full=Auxin efflux carrier-like protein 6 {ECO:0000303|PubMed:22504182};
GN   Name=PILS6 {ECO:0000303|PubMed:22504182};
GN   OrderedLocusNames=At5g01990 {ECO:0000312|Araport:AT5G01990};
GN   ORFNames=T7H20_40 {ECO:0000312|EMBL:CAB82972.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
RA   Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
RA   Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
RA   van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
RA   Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
RA   Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
RA   Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY, INDUCTION BY AUXIN, GENE FAMILY, NOMENCLATURE, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=22504182; DOI=10.1038/nature11001;
RA   Barbez E., Kubes M., Rolcik J., Beziat C., Pencik A., Wang B.,
RA   Rosquete M.R., Zhu J., Dobrev P.I., Lee Y., Zazimalova E.,
RA   Petrasek J., Geisler M., Friml J., Kleine-Vehn J.;
RT   "A novel putative auxin carrier family regulates intracellular auxin
RT   homeostasis in plants.";
RL   Nature 485:119-122(2012).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=23091477; DOI=10.3389/fpls.2012.00227;
RA   Feraru E., Vosolsobe S., Feraru M.I., Petrasek J., Kleine-Vehn J.;
RT   "Evolution and structural diversification of PILS putative auxin
RT   carriers in plants.";
RL   Front. Plant Sci. 3:227-227(2012).
CC   -!- FUNCTION: Involved in cellular auxin homeostasis by regulating
CC       auxin metabolism. Regulates intracellular auxin accumulation at
CC       the endoplasmic reticulum and thus auxin availability for nuclear
CC       auxin signaling. {ECO:0000305|PubMed:22504182}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:22504182}; Multi-pass membrane protein
CC       {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in seedlings, rosette and cauline
CC       leaves, stems and flowers. {ECO:0000269|PubMed:22504182}.
CC   -!- INDUCTION: Up-regulated by auxin application.
CC       {ECO:0000269|PubMed:22504182}.
CC   -!- SIMILARITY: Belongs to the auxin efflux carrier (TC 2.A.69.2)
CC       family. {ECO:0000305}.
DR   EMBL; AL162508; CAB82972.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED90417.1; -; Genomic_DNA.
DR   PIR; T48220; T48220.
DR   RefSeq; NP_195819.1; NM_120277.3.
DR   UniGene; At.33476; -.
DR   UniGene; At.67240; -.
DR   ProteinModelPortal; Q9LZN2; -.
DR   STRING; 3702.AT5G01990.1; -.
DR   PaxDb; Q9LZN2; -.
DR   EnsemblPlants; AT5G01990.1; AT5G01990.1; AT5G01990.
DR   GeneID; 830729; -.
DR   Gramene; AT5G01990.1; AT5G01990.1; AT5G01990.
DR   KEGG; ath:AT5G01990; -.
DR   Araport; AT5G01990; -.
DR   TAIR; locus:2185123; AT5G01990.
DR   eggNOG; KOG2722; Eukaryota.
DR   eggNOG; COG0679; LUCA.
DR   HOGENOM; HOG000238399; -.
DR   OMA; GIFNAWL; -.
DR   OrthoDB; EOG093609KV; -.
DR   PhylomeDB; Q9LZN2; -.
DR   PRO; PR:Q9LZN2; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LZN2; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0009733; P:response to auxin; IEP:UniProtKB.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR004776; Mem_trans.
DR   Pfam; PF03547; Mem_trans; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9LZN2.
DR   SWISS-2DPAGE; Q9LZN2.
KW   Auxin signaling pathway; Complete proteome; Endoplasmic reticulum;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    431       Protein PIN-LIKES 6.
FT                                /FTId=PRO_0000436501.
FT   TOPO_DOM      1     29       Lumenal. {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM     30     50       Helical. {ECO:0000255}.
FT   TOPO_DOM     51     66       Cytoplasmic.
FT                                {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM     67     87       Helical. {ECO:0000255}.
FT   TOPO_DOM     88     93       Lumenal. {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM     94    114       Helical. {ECO:0000255}.
FT   TOPO_DOM    115    128       Cytoplasmic.
FT                                {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM    129    149       Helical. {ECO:0000255}.
FT   TOPO_DOM    150    169       Lumenal. {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM    170    190       Helical. {ECO:0000255}.
FT   TOPO_DOM    191    268       Cytoplasmic.
FT                                {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM    269    289       Helical. {ECO:0000255}.
FT   TOPO_DOM    290    306       Lumenal. {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM    307    327       Helical. {ECO:0000255}.
FT   TOPO_DOM    328    340       Cytoplasmic.
FT                                {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM    341    361       Helical. {ECO:0000255}.
FT   TOPO_DOM    362    376       Lumenal. {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM    377    397       Helical. {ECO:0000255}.
FT   TOPO_DOM    398    406       Cytoplasmic.
FT                                {ECO:0000305|PubMed:23091477}.
FT   TRANSMEM    407    427       Helical. {ECO:0000255}.
FT   TOPO_DOM    428    431       Lumenal. {ECO:0000305|PubMed:23091477}.
SQ   SEQUENCE   431 AA;  46465 MW;  17129A921784CB74 CRC64;
     MIARILAALA DSMEMPVAAG GGSVLGTIKI AVMPIAKVFT MCFLGLLMAS KYVNILPPSG
     RKLLNGLVFS LLLPCLIFSQ LGQAVTLQKM LQWWFIPVNV VLGTISGSII GFIVASIVRP
     PYPYFKFTII QIGVGNIGNV PLVLLAALCR DTSNPFGDSE KCSIDGTAYI SFGQWVGAII
     LYTYVYQMFA PPPEGFDAEE ENLALKTLPV DAAPEQVPLL TQNFPKDFSP TQDLLPVQST
     EPRGRGVSRK GKIAQIFVFL YEKLKLKQIV QPAIVASILA MILGAIPFTK KLIFTNGAPL
     FFFTDSCMIL GDAMIPCILL ALGGNLINGP GSSKLGFKTT AAIIIGRLVL VPPVGLGIVT
     VADKLGFLPA DDKMFRFVLL LQHTMPTSVL SGAVANLRGC GRESAAVLFW VHIFAIFSMA
     GWMVLYINIL F
//

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