(data stored in ACNUC23182 zone)

SWISSPROT: B0W3G9_CULQU

ID   B0W3G9_CULQU            Unreviewed;       629 AA.
AC   B0W3G9;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   10-APR-2019, entry version 61.
DE   RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|PIRNR:PIRNR018300};
GN   Name=6032693 {ECO:0000313|VectorBase:CPIJ001713-PA};
GN   ORFNames=CpipJ_CPIJ001713 {ECO:0000313|EMBL:EDS31312.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176 {ECO:0000313|Proteomes:UP000002320};
RN   [1] {ECO:0000313|Proteomes:UP000002320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|Proteomes:UP000002320};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J.,
RA   Mauceli E., Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L.,
RA   Amedeo P., Antoine C.H., Arensburger P., Bidwell S.L., Crawford M.,
RA   Camaro F., Devon K., Engels R., Hammond M., Howarth C., Koehrsen M.,
RA   Lawson D., Montgomery P., Nene V., Nusbaum C., Puiu D.,
RA   Romero-Severson J., Severson D.W., Shumway M., Sisk P., Stolte C.,
RA   Zeng Q., Eisenstadt E., Fraser-Liggett C.M., Strausberg R.,
RA   Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDS31312.1, ECO:0000313|VectorBase:CPIJ001713-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS31312.1,
RC   ECO:0000313|VectorBase:CPIJ001713-PA};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:CPIJ001713-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|VectorBase:CPIJ001713-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: May play an essential role at the early stage of
CC       chromosomal DNA replication by coupling the polymerase
CC       alpha/primase complex to the cellular replication machinery.
CC       {ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC       {ECO:0000256|PIRNR:PIRNR018300}.
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DR   EMBL; DS231831; EDS31312.1; -; Genomic_DNA.
DR   RefSeq; XP_001843253.1; XM_001843201.1.
DR   STRING; 7176.CPIJ001713-PA; -.
DR   EnsemblMetazoa; CPIJ001713-RA; CPIJ001713-PA; CPIJ001713.
DR   GeneID; 6032693; -.
DR   KEGG; cqu:CpipJ_CPIJ001713; -.
DR   VectorBase; CPIJ001713-RA; CPIJ001713-PA; CPIJ001713.
DR   eggNOG; KOG1625; Eukaryota.
DR   eggNOG; COG5214; LUCA.
DR   HOGENOM; HOG000044249; -.
DR   InParanoid; B0W3G9; -.
DR   KO; K02321; -.
DR   OMA; QFDEMGV; -.
DR   OrthoDB; 513979at2759; -.
DR   PhylomeDB; B0W3G9; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016722; DNA_pol_alpha_bsu.
DR   PANTHER; PTHR23061; PTHR23061; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   PIRSF; PIRSF018300; DNA_pol_alph_2; 2.
PE   3: Inferred from homology;
DR   PRODOM; B0W3G9.
DR   SWISS-2DPAGE; B0W3G9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002320};
KW   DNA replication {ECO:0000256|PIRNR:PIRNR018300};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT   DOMAIN      381    579       DNA_pol_E_B. {ECO:0000259|Pfam:PF04042}.
SQ   SEQUENCE   629 AA;  69324 MW;  99E391C77720DB9A CRC64;
     MVTIQSIKEQ FDEFGLEPSD EIVEKCIQIC NRHGVVDPVE FVEQWFAYSC SKLGGAEPTL
     DNLRDMESHE YANRSRKPAA NPSLARVRHG EVAVVASSSG SGGGSGGLVI YSNAEENEVE
     NEVLGSYGCH TPKTKKRPVS RLLAQTPDKP NKAQFAPASY SPIAPSKKSA DEEQPSNSGN
     VVYTFGNAFL LKQTSWSSSA TAGAPSDDLP KCMGDACKYM YDSNYDRVLI LGDRIYEGGR
     EICQRLAEAR KQQRDRGNGA SAEEEVIPED DREATLLEQV AIHHVDYPST DVITVLGRIA
     VHPERQEGGR LAIVDYDEMT LRYTKLDFSK LKSWSVFPGE TVVLEGVNPR GNLFEVRKVH
     YEVPLAPPPA PTTIGKPLHM VIGAAPFTDK DNLQYDKLSD LLAYCAENNP DVLILTGPFG
     STSNDTLFLT IAESFEEYFE KIMANIVTSV PPTTEILIVS NHDDLQSSFV YPSFPYKISK
     FYKNLHFLPD PCVVSINGMH VAITTVDVVR DLSEAELSVA PSGDKIKRAF NYMFHHRSFY
     PLNPPPESVP LDVDLLHHFG TLPRVPNVMI CPGDLKPYVR DVNGCVCVNP GHLTDYDSGE
     GTFARVVVHP PEEPTAAPFS YVACQVVKS
//

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